1/19. Subglottic haemangioma: controversies in management.OBJECTIVE: To discuss treatment modalities for subglottic haemangioma (SGH). METHODOLOGY: Case report of two children definitively managed by different modalities. RESULTS: Management by CO2 laser vaporization in one child, and laser followed by interferon 2-alpha in the second child were both successful in controlling the SGH without the need for tracheostomy. CONCLUSION: The stepped-care approach at John Hunter Children's Hospital, Newcastle, new south wales, is presented. Both laser surgery and interferon can help control SGH. Careful surveillance and interdisciplinary cooperation are essential to achieve a good outcome.- - - - - - - - - - ranking = 1keywords = angioma (Clic here for more details about this article) |
2/19. Spontaneously regressed Kaposi's sarcoma and human herpesvirus 8 infection in a human immunodeficiency virus-negative patient.Kaposi's sarcoma occurring in a 78-year-old woman, with the absence of the human immunodeficiency virus infection, was correctly diagnosed by immunohistochemistry using anti-human herpesvirus 8 (HHV8) antibody (PA1-73N) for the first time. The patient suffered from chronic respiratory failure and was treated with a low dose of steroids for 2.5 years. After her medication dosage was increased for the exacerbation of the respiratory failure, multiple skin tumors in her feet and legs suddenly developed. Histopathologically, skin tumors were suspected as Kaposi's sarcoma at the first biopsy and reactive angiomatosis at the second biopsy. polymerase chain reaction and immunohistochemistry, however, revealed the presence of HHV8 dna fragment and positive staining in the majority of spindle cells in the skin tumors. Serological examination confirmed the positivity of anti-HHV8 antibodies. HHV8 infection and steroid-induced immunosuppression, as well as environmental factors played a role in the development of Kaposi's sarcoma in this patient, because she was born in Okinawa, which is a well-known endemic area of Kaposi's sarcoma in japan. As her general condition improved, the skin lesions regressed without any specific treatment, and disappeared completely 8 months later, in which regression may be associated with evidence of numerous CD8 cell infiltration in the second biopsy tissues. No recurrence was observed during the following 6 month follow up.- - - - - - - - - - ranking = 0.2keywords = angioma (Clic here for more details about this article) |
3/19. Tufted angioma of adult onset, revealing abundant eccrine glands and central regression.Tufted angioma (angioblastoma) usually occurs in infancy. Some lesions reveal proliferation of eccrine glands and some undergo spontaneous regression. We report a lesion from the left lateral chest of a 58-year-old male, which had appeared 5 years ago and gradually increased in size. Its color had faded out centrally. Histological examination showed many angiomatous lobules on the border of the lesion but few in the central portion. Abundant eccrine sweat glands, small venules and dense connective tissue were seen in both areas. The histology and the clinical course suggested that central regression occurred in the lesion. Out of 211 reported cases, we found 4 cases that had annular lesions spreading centrifugally. Though these lesions were not examined histologically, they were suspected to regress in the central portions. We suggest that central regression can rarely occur in tufted angioma.- - - - - - - - - - ranking = 1.4keywords = angioma (Clic here for more details about this article) |
4/19. Regression of congenital fibrosarcoma to hemangiomatous remnant with histological and genetic findings.We report a rare case of congenital fibrosarcoma (CFS) showing regression during the course of disease, in which the histological and genetic alterations were investigated. This CFS, located on the patient's right hand, was a hemangiopericytomatous hypervascular tumor showing frequent mitosis and necrosis. Small lymphocytes, predominantly cytotoxic T cells and natural killer cells, infiltrated the tumor. At the age of 3 months, the patient received a partial resection of the tumor. At the age of 1 year, the hemangiopericytomatous tumor with a dilated vascular lumen remained, although most of the tumor cells exhibited focal necrosis with calcification and no mitotic activity. lymphocytes increased in number and intermingled with the tumor cells. At the age of 4 years, vascular tissue consisting of inner endothelial cells and surrounding pericytomatous actin-positive cells remained at the previous tumor locus. With reverse transcription-polymerase chain reaction analysis, ETV6-NTRK3 fusion transcripts were detected in tumor samples at 3 months and at 1 year, but not from those at 4 years of age. These genetic and histological changes suggest that the CFS either completely disappeared by apoptosis or showed mature transformation to hemangiomatous tissue with aging.- - - - - - - - - - ranking = 1.6168462999862keywords = angioma, hemangioma (Clic here for more details about this article) |
5/19. Eruptive tufted angiomas in a patient with Crohn's disease.Angioblastoma is a rare, benign vascular tumour composed of undifferentiated mesenchymal cells with a tendency to form lumina. This entity was first described by Nakagawa in 1949 as angioblastoma, and Wilson Jones was the first to use the term "tufted angioma" in 1976. Tufted angiomas usually occur in infancy and spread slowly. This report describes lesions from the right side of the forehead, forearms, and thighs of a 24 year old man with a four year history of Crohn's disease, who was receiving infliximab in addition to long standing azathioprine and ciprofloxacillin. He developed numerous small itchy erythematous vascular appearing papules, which on histological examination resembled tufted angiomas, showing the classic "cannon ball" appearance. The lesions regressed within three months. This case may represent an eruptive acquired tufted angioma in which immunosuppression or drug induced modification of angiogenesis played a role in its development and regression. One previous case of eruptive tufted angioma has been reported in an immunosuppressed patient.- - - - - - - - - - ranking = 1.8keywords = angioma (Clic here for more details about this article) |
6/19. The spontaneous regression of tufted angioma. A case of regression after two recurrences and a review of 27 cases reported in the literature.BACKGROUND: Tufted angioma, a peculiar angioma that is characterized by tufts of capillary-sized vessels scattered 'cannonball fashion' within the dermis, is known, on occasion, to regress spontaneously. However, the appropriate waiting period for spontaneous regression has remained unclear. OBJECTIVE: To know the appropriate waiting period for spontaneous regression of tufted angioma. methods: We report here a case of tufted angioma that regressed spontaneously after the lesions had recurred twice. We also review previously reported cases of tufted angioma with spontaneous regression, including cases in the Japanese and non-Japanese literature. RESULTS: In 18 (86%) of the 21 cases, the waiting period was more than 6 months and in 20 cases (95%) it was less than 2 years. CONCLUSION: The appropriate wait for spontaneous regression might be between 6 months and 2 years.- - - - - - - - - - ranking = 1.8keywords = angioma (Clic here for more details about this article) |
7/19. Spontaneous regression of retinal angiomatous lesions in v. Hippel-Lindau disease (VHL).BACKGROUND: Very little documentation of spontaneous regression of an angiomatous retinal lesion in v. Hippel-Lindau disease (VHL) exists. It is commonly believed that a spontaneous change of hemangiomas into fibrotic lesions occurred. patients/methods: Follow-up examinations of four patients with VHL in the Freiburg VHL study were carried out. RESULTS: A 16-year-old girl revealed a vascular lesion at the border of the optic disc. Control examination nine years later revealed complete spontaneous regression of the retinal vascular changes. A slight retinal vascular change at the superior border in her right eye was found in a 36-year-old woman. A control examination 20 years later revealed regression of the lesion. A 41-year-old woman showed in the retinal periphery a small fibrotic white hemangioma with a pigmented feeder vessel as sign of spontaneous tumor regression. A 12-year-old boy had a retinal microaneurysm inferior to the optic disc that disappeared several years later. CONCLUSION: Documentations of spontaneous regression of minor angiomatous retinal lesions in VHL exist. Such vascular changes are rare. Every retinal lesion should be controlled by follow-up examination and documentation. In case of retinal lesion growth, treatment is necessary.- - - - - - - - - - ranking = 1.8467385199945keywords = angioma, hemangioma (Clic here for more details about this article) |
8/19. Congenital, self-regressing tufted angioma.BACKGROUND: Tufted angioma (known in Japanese literature as angioblastoma of Nakagawa) is an uncommon, histologically benign, vascular tumor. Lesions typically present during infancy or early childhood and are most commonly reported to persist and/or expand over time. Congenital presentations are rare, as are reports of spontaneous regression. OBSERVATIONS: We present a series of 5 histopathologically confirmed cases of congenital tufted angioma that spontaneously regressed during infancy or early childhood. We also review the literature, focusing on both congenital and early-onset cases in infants.CONCLUSION: We recommend that observation for potential regression be considered for otherwise uncomplicated congenital or early infantile cases of tufted angioma.- - - - - - - - - - ranking = 1.4keywords = angioma (Clic here for more details about this article) |
9/19. Localized form of multiple glomus tumors: report of the first case showing partial involution.We recently examined a boy with relatively large multiple glomus tumors on the left scapular region. Histologic examination revealed a typical non-capsulated glomangioma in the middle and deep dermis; by electron microscopic examination, the tumor cells were seen to exhibit a characteristic smooth muscle cell structure. Thermographic examination revealed the higher temperature of the tumor. Within a year, the tumor showed a partial involution. We think this is the first report of multiple glomus tumor showing a partial involution.- - - - - - - - - - ranking = 0.2keywords = angioma (Clic here for more details about this article) |
10/19. Clinical course of an incompletely removed cavernous hemangioma of the orbit.Cavernous hemangioma is a frequent tumor of the orbit in adults. Its complete removal results in dramatic relief of proptosis. The clinical course of an incompletely removed cavernous hemangioma is seldom recorded in the ophthalmic literature. The authors report the behavior of such a tumor that was observed during an 18-year period. Serial computed tomography (CT) documented a long period of slow growth, followed by a shorter interval of arrest, with eventual involution of tumor and relief of proptosis. No treatment was administered during observation.- - - - - - - - - - ranking = 1.9402155599834keywords = angioma, hemangioma (Clic here for more details about this article) |
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