1/12. bowen's disease showing spontaneous complete regression associated with apoptosis.Spontaneous regression is sometimes seen in malignant skin tumours. We report a 68-year-old woman whose bowen's disease showed spontaneous complete regression. Prominent infiltration of T cells and increased vascularity were found in the upper dermis of the regressed lesion. Strong expression of Fas (APO-1/CD95) antigen, an apoptosis-related tumour necrosis factor receptor family protein, in the primary lesion and faint expression following regression suggest the involvement of Fas-mediated apoptosis in the spontaneous complete regression of our patient's bowen's disease.- - - - - - - - - - ranking = 1keywords = dermis (Clic here for more details about this article) |
2/12. A case of intravascular large B-cell lymphoma mimicking erythema nodosum: the importance of multiple skin biopsies.BACKGROUND: Intravascular lymphoma is a rare disease characterized by the proliferation of neoplastic monuclear cells within the lumens of small blood vessels. The neoplastic cells are usually of B-cell origin, and rarely of T-cell or histiocytic origin. Although this clinicopathological entity of lymphoma has not been listed in general pathological classifications such as REAL classification or the Working Formulation, it is recently in the WHO classification scheme, which is essentially an updated REAL scheme, and the EORTC classification scheme. methods: In this report, a 62-year-old woman with intravascular large B-cell lymphoma was observed by clinical, histopathological, immunohistochemical and molecular methods. RESULTS: A 62-year-old woman presented with large erythematous macules on the bilateral thighs and lower legs. The lesions were accompanied with hard, tender, intradermal or subcutaneous nodules mimicking erythema nodosum. Histopathological examination in the first biopsy revealed non-specific panniculitis compatible with erythema nodosum. The second biopsy revealed emboli of atypical lymphocytes within many of the dilated and proliferated vessels in the deep dermis and subcutaneous tissue. These cells were positive for L-26 and kappa light chain, and negative for lambda light chain, factor viii-related antigen, CD30, CD34, CD68 and UCHL-1. These findings confirmed the diagnosis of intravascular large B-cell lymphoma. A laboratory examination showed a high level of LDH and abnormal cells in the bone marrow. An MRI of the brain and computed tomographic (CT) scans of the chest and abdomen revealed no evidence of malignancy. Before the treatment, the size of the nodules decreased spontaneously by about 50% in one month and significantly in two months. Although combination chemotherapy, which consisted of CHOP, brought her partial remission, she experienced neurological symptoms 6 months after the initial treatment and died of brain metastasis 9 months after the treatment. CONCLUSIONS: This is a unique case for two following reasons: 1) the first biopsy revealed non-specific findings compatible with erythema nodosum; and 2) before the treatment, the nodules regressed spontaneously. Dermatologists should take multiple skin biopsies for EN lesions with the non-specific histopathological findings not to refute the existence of this disease.- - - - - - - - - - ranking = 1keywords = dermis (Clic here for more details about this article) |
3/12. Spontaneous regression of multiple seborrheic keratoses associated with nasal carcinoma.Seborrheic keratoses are very common epidermal neoplasms. We describe a patient with seborrheic keratoses presenting multifocal spontaneous regression. The patient had a concurrent nasal adenoid cystic carcinoma. The simultaneous regression of seborrheic keratoses ceased after total resection of the nasal carcinoma. Histological examination revealed marked infiltration of mononuclear cells, including CD4 , CD8 , CD68 and cutaneous lymphocyte-associated antigen-positive cells, with profound accumulation of CD1a dendritic cells. Although apoptotic keratinocytes were not found in the lesional epidermis by histology, the majority of keratinocytes in the regressing seborrheic keratosis were positively stained by the TUNEL method. We postulate that the internal malignancy may induce spontaneous regression of seborrheic keratoses.- - - - - - - - - - ranking = 1keywords = dermis (Clic here for more details about this article) |
4/12. The spontaneous regression of tufted angioma. A case of regression after two recurrences and a review of 27 cases reported in the literature.BACKGROUND: Tufted angioma, a peculiar angioma that is characterized by tufts of capillary-sized vessels scattered 'cannonball fashion' within the dermis, is known, on occasion, to regress spontaneously. However, the appropriate waiting period for spontaneous regression has remained unclear. OBJECTIVE: To know the appropriate waiting period for spontaneous regression of tufted angioma. methods: We report here a case of tufted angioma that regressed spontaneously after the lesions had recurred twice. We also review previously reported cases of tufted angioma with spontaneous regression, including cases in the Japanese and non-Japanese literature. RESULTS: In 18 (86%) of the 21 cases, the waiting period was more than 6 months and in 20 cases (95%) it was less than 2 years. CONCLUSION: The appropriate wait for spontaneous regression might be between 6 months and 2 years.- - - - - - - - - - ranking = 1keywords = dermis (Clic here for more details about this article) |
5/12. A case of peripheral T-cell lymphoma unspecified involving subcutaneous tissue.A 36-year-old man presented with a 3-year-old red-brown plaque with subcutaneous nodules on his left thigh. Although a similar lesion was observed on his right thigh 3 years earlier, it spontaneously disappeared 1 year later. However, the lesion on the left thigh was growing larger. Histologically, the lesion showed a diffuse and dense infiltration of atypical lymphocytes extending from the superficial dermis to the subcutaneous tissue. Severe lobular panniculitis, composed of small- and medium-sized atypical lymphocytes and large normal histiocytes, was observed in the subcutaneous adipose tissue. Immunohistochemical studies revealed a post-thymic T-cell phenotype. A genetic analysis demonstrated a rearrangement of the T-cell receptor chain gene. The left skin lesion also gradually disappeared after skin biopsy without therapy, and he continues to be in remission.- - - - - - - - - - ranking = 1keywords = dermis (Clic here for more details about this article) |
6/12. Localized form of multiple glomus tumors: report of the first case showing partial involution.We recently examined a boy with relatively large multiple glomus tumors on the left scapular region. Histologic examination revealed a typical non-capsulated glomangioma in the middle and deep dermis; by electron microscopic examination, the tumor cells were seen to exhibit a characteristic smooth muscle cell structure. Thermographic examination revealed the higher temperature of the tumor. Within a year, the tumor showed a partial involution. We think this is the first report of multiple glomus tumor showing a partial involution.- - - - - - - - - - ranking = 1keywords = dermis (Clic here for more details about this article) |
7/12. Pigmentary regression in a giant nevocellular nevus: a case report and a review of the subject.A giant congenital nevocytic nevus (CNN) on the trunk was followed in a patient from age three months to 23-years-old. During that time the nevus underwent pigmentary regression leaving 2-3 mm lentigines without any evidence of vitiligo or halo formation around the giant CNN. Histopathologically, nevus cells remained in the dermis.- - - - - - - - - - ranking = 1keywords = dermis (Clic here for more details about this article) |
8/12. An immunohistochemical and ultrastructural study of an unusual case of multiple non-X histiocytoma.An immunohistochemical and ultrastructural study of an atypical case of multiple non-X histiocytoma was done. There was involvement of the skin, lungs, and liver in a 3-month-old male infant. Microscopic examination of the cutaneous tumors revealed a dense infiltration of cells with polymorphous large nuclei and abundant eosinophilic cytoplasm in the entire dermis. Both immunohistochemical and electron microscopic studies suggested that the tumors were non-X histiocytomas. The patient's condition deteriorated with dyspnea due to rapid enlargement of tumor masses in the liver and lungs. However, at 5 months of age, the cutaneous nodules and pulmonary and hepatic lesions showed a tendency to involute. Furthermore, at 12 months of age, they were no longer detectable. The patient at 24 months of age was well with normal development. To date, no recurrence of the disease has been observed.- - - - - - - - - - ranking = 1keywords = dermis (Clic here for more details about this article) |
9/12. Transepidermal elimination of nevus cells. A possible mechanism of nevus involution.nevus cell nests were seen histologically within the upper levels of the epidermis in biopsy specimens obtained from three patients with clinically banal-appearing nevi. Although the presence of melanocytes arranged as solitary units or grouped in nests in the upper layers of the epidermis is one histopathologic feature of malignant melanoma, we believe this finding represents transepidermal elimination of nevus cells and may be one mechanism of nevus involution.- - - - - - - - - - ranking = 2keywords = dermis (Clic here for more details about this article) |
10/12. Regressed primary malignant melanoma with regional metastases.Eleven cases of metastatic malignant melanoma with a completely regressed primary melanoma have been described. An additional case is reported here. The patient had melanoma metastatic to femoral lymph nodes and a pigmented lesion on the lower part of the leg. The pigmented lesion showed fibrosis, increased numbers of capillaries, and a band-like infiltrate of melanophages in the dermis. No residual melanoma was found. The findings in this case are similar to those previously reported.- - - - - - - - - - ranking = 1keywords = dermis (Clic here for more details about this article) |
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