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1/7. Primary leiomyoma of the ovary co-existing with serous cystadenofibroma.

    A 48-year-old woman with a 14 cm left ovarian mass had total abdominal hysterectomy and bilateral salpingo-oophorectomy. On cut section the tumor had a solid and a cystic component. There was a 2.5 cm nodule attached to the cyst wall. Sections taken from the solid component revealed a tumor composed of interlacing bundles of fusiform cells, resembling a leiomyoma. Smooth muscle actin positivity confirmed the diagnosis. Sections taken from the nodule in the cystic part revealed an adenofibroma. There was an SMA positive area in the cyst wall which we think is the possible origin of the leiomyoma. As far as we know, this is the first case of a co-existing leiomyoma and serous cystadenofibroma in the ovary, and we think it will broaden the histological spectrum of primary ovarian leiomyomas.
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ranking = 1
keywords = cystadenofibroma
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2/7. endodermal sinus tumor and mucinous cystadenofibroma of the ovary. Occurrence in an 82-year-old woman.

    We encountered an unusual ovarian tumor consisting of a mixture of typical endodermal sinus tumor (EST) and mucinous cystadenofibroma that occurred in the ovary of an 82-year-old female patient. The EST component showed the classic histologic features of this tumor. serum alpha-fetoprotein (AFP) level was not determined. Tumor stains were negative for AFP but positive for alpha-1-antitrypsin. The malignant germ cell component was intimately associated with the benign mucinous component. Focal production of epithelial mucin and carcinoembryonic antigen (CEA) in the EST component suggested a probable association between the two tumor types. The tumor was confined to one ovary, and the patient is disease-free 2 years after surgical therapy. This neoplasm is unique not only for the malignant germ cell component occurring in an 82-year-old woman, but for the unusual combination of tumor types. The pathogenesis is unknown.
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ranking = 1
keywords = cystadenofibroma
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3/7. Invasive ovarian endometrioid adenofibroma with omental implants and collision with endometrial adenocarcinoma.

    A case of endometrioid adenofibroma of the ovary with omental implants, extensive invasion into the wall of the ipsilateral fallopian tube, and collision with an endometrial papillary adenocarcinoma is reported. Fewer than 35 malignant cystadenofibromas and adenofibromas have been reported. In all of these cases, the malignant epithelium was believed to originate from preexisting benign tumors. This case is unusual in that it demonstrated no malignant epithelium beyond that of a borderline tumor, but met the criteria of malignancy because of its invasiveness and metastasis.
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ranking = 0.2
keywords = cystadenofibroma
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4/7. Does ovarian sex cord tumour with annular tubules produce progesterone?

    Probable progesterone production was identified by an immunoperoxidase assay in a case of an ovarian sex cord tumour with annular tubules. The tumour was associated with a serous cystadenofibroma in the opposite ovary and with adenoma malignum (adenocarcinoma) of the cervix.
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ranking = 0.2
keywords = cystadenofibroma
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5/7. Multicentric ovarian and extraovarian cystadenofibroma.

    A case of multicentric ovarian and diffuse pelvic cystadenofibroma is described. Despite multicentricity, the histologic findings are completely benign. Electron microscopy was performed and possible mesothelial origin is discussed.
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ranking = 1
keywords = cystadenofibroma
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6/7. Ovarian endometrioid carcinoma with an adenofibromatous pattern.

    We report the case of a 66-year-old postmenopausal woman who underwent unilateral oophorectomy for an ovarian endometrioid carcinoma with an unusual adenofibromatous stromal reaction pattern. She is presently alive, well and without clinical evidence of tumour two years after surgery. Adenofibromatous or cystadenofibromatous reaction is a peculiar reactive ovarian stromal change most probably induced by the invading neoplastic epithelial cells. No definite conclusions have been reached regarding the prognostic significance of this special stromal tissue reaction in cases of endometrioid carcinoma of the ovary.
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ranking = 0.2
keywords = cystadenofibroma
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7/7. Coexisting adenocarcinoma and cystadenofibroma (malignant cystadenofibroma) of the ovary.

    We have described an adenocarcinoma observed as a grossly discrete area within a cystadenofibroma of the ovary. Fewer than 35 cases of malignant cystadenofibroma have been reported. We find our observations lend support to the prevailing thought that these neoplasms most often originate from preexisting cystadenofibromas.
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ranking = 2.2
keywords = cystadenofibroma
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