1/8. Inflammatory myofibroblastic tumour of paranasal sinuses with fatal outcome: reactive lesion or tumour?Inflammatory myofibroblastic tumours (IMTs) are clinicopathologically distinctive but biologically controversial entities, which have been described in the lungs, abdomen, retroperitoneum, and extremities, but rarely affect the head and neck region. IMT usually follows a benign clinical course after radical excision, but invasive, locally recurrent, and metastatic forms of abdominal and mediastinal IMT have also been described. This report describes a case of IMT of the paranasal sinuses with a fatal outcome. A 22 year old woman was admitted to hospital as a result of epistaxis. Computed tomography scan and magnetic resonance imaging showed an expansive process in the paranasal sinuses, extending into the nasal cavity, orbita, and endocranium. The tumour progressed despite several surgical procedures. radiotherapy, corticosteroids, and chemotherapy were unsuccessful, and the patient died four years after diagnosis, as a result of extensive intracranial spread of the tumour. This is the first known case of an IMT of the head and neck region with a fatal outcome. It shows that the aggressive behaviour of IMTs is not limited to abdominal and mediastinal locations, and supports recent observations that at least a subset of IMTs represents true neoplasia rather than reactive myofibroblastic proliferation.- - - - - - - - - - ranking = 1keywords = cavity (Clic here for more details about this article) |
2/8. Inflammatory myofibroblastic tumor of the stomach with peritoneal dissemination in a young adult: imaging findings.Inflammatory myofibroblastic tumors are lesions that most often affect young adults and children. These tumors have been found in numerous extrapulmonary sites but rarely in the stomach. It is unknown whether this process is reactive or neoplastic. They are infiltrative lesions and often extend through the gastric wall, sometimes reaching adjacent organs including the esophagus, duodenum, peritoneal cavity, spleen. pancreas, and liver. These features mimic malignancy on endoscopy and radiology. We report the ultrasound, color Doppler ultrasound, and helical computed tomographic findings of a gastric inflammatory myofibroblastic tumor with peritoneal dissemination in a young adult. To our knowledge, this is the first report of color Doppler ultrasound and helical computed tomographic findings of this rare disease entity.- - - - - - - - - - ranking = 1keywords = cavity (Clic here for more details about this article) |
3/8. Myofibroblastic tumor of the oral cavity. A rare clinical entity.Inflammatory myofibroblastic tumor is a rare clinical entity that can first present in the oral cavity. Though considered a benign lesion, it can behave very locally and aggressively, with significant bony destruction. A rare case of inflammatory myofibroblastic tumor is presented, along with the surgical treatment and an overview of this interesting clinical lesion.- - - - - - - - - - ranking = 108.84938079186keywords = oral cavity, cavity (Clic here for more details about this article) |
4/8. Clinico-pathologic correlations of myofibroblastic tumors of the oral cavity: 1. Nodular fasciitis.BACKGROUND: Nodular fasciitis (NF), a soft tissue lesion mainly composed of myofibroblastic cells, is well documented in various body locations however, in the oral cavity it is rare. The NF has non-specific histologic characteristics that might result in misdiagnosis and mistreatment. The aim of the study was to analyze clinico-pathologic correlations of NF occurring in the oral cavity. methods: A total of 36 cases of oral NF were analyzed including review of the English language literature and five new cases from our files. RESULTS: Oral mucosa NF was found to peak in the fourth and fifth decades, which is a decade later than NF occurring in other sites of the body. The most common locations were the buccal mucosa (52.8%) and the lips (16.7%). Duration of lesions ranged from 3 days to 2 years, with approximately 61% being present for more than a month, which is longer than the duration of NF from other body locations. Histologically, oral NF showed varying degrees of cellularity and frequently contained myxomatous areas, and often demonstrated local infiltration into adjacent tissues. However, the myofibroblastic, spindle-shaped lesional cells were uniform and lacked any major signs of atypia. Mitotic figures, characteristically abundant in NF lesions throughout the body, ranged from absent to moderately high in oral NF cases. Treatment modality of choice was complete surgical excision. recurrence was reported for only one case. Extensive, mutilating surgical procedures for oral mucosa NF are unnecessary, since lesions resolve even when surgical margins are partly involved. CONCLUSIONS: The NF should be included in the clinical differential diagnosis of superficial and deep soft tissue masses of the oral cavity, especially of the buccal mucosa. Histopathologically, NF should be differentiated from other spindle cell lesions, mainly myofibroma, neurofibroma, fibrosarcoma, solitary fibrous tumor, fibromatosis and fibrous histiocytoma.- - - - - - - - - - ranking = 152.3891331086keywords = oral cavity, cavity (Clic here for more details about this article) |
5/8. Intra-abdominal inflammatory myofibroblastic pseudotumor: case report and review of the literature.Inflammatory myofibroblastic pseudotumors (IPM) are very rare tumor characterized by unpredictable clinical behaviour. They arise in soft tissues of almost every organ and the most common site is the lung. Over 200 cases of inflammatory myofibroblastic pseudotumor of the lung have been described in literature. Intra-abdominal IMP are very rare. We describe a case of intra-abdominal IMP in a boy of 15 years old who presented symptoms and signs of acute appendicitis. Exploratory laparotomy revealed a mass in the peritoneal cavity. The mass was removed. The histologic examination showed that it was an IMP. Surgical treatment was the only therapy. Six months after the surgical operation the patient has no sign of illness.- - - - - - - - - - ranking = 1keywords = cavity (Clic here for more details about this article) |
6/8. Inflammatory myofibroblastic tumor of the uterus with prominent myxoid change.A surgical case of inflammatory myofibroblastic tumor arising in the uterine corpus and exhibiting prominent myxoid change of the stroma is reported. The patient was a 63-year-old woman with a large tumor mass that filled the uterine cavity and measured 11 cm in maximal dimension. The tumor had a gelatinous appearance and consisted of a loose proliferation of stellate or polygonal cells on a myxomatous background. Fascicular proliferation of spindle cells was also observed focally, and a chronic inflammatory cell infiltration was seen in many areas. Tumor cells had mild atypism and were immunoreactive for vimentin, alpha-smooth muscle actin, and anaplastic lymphoma kinase (ALK). Focal immunoreactivity for high-molecular-weight caldesmon (h-caldesmon) was also noted. The patient has been free from recurrence for 8 months. Inflammatory myofibroblastic tumor of the uterus occasionally shows prominent myxoid change of the stroma, and differentiation from myxoid leiomyosarcoma is problematic in these cases. Based on the immunoreactivity of tumor cells for ALK and h-caldesmon, the present tumor was considered inflammatory myofibroblastic tumor showing a focal phenotypic transition from myofibroblasts to smooth muscle cells.- - - - - - - - - - ranking = 1keywords = cavity (Clic here for more details about this article) |
7/8. Granular cell myoblastoma in Nigerian Igbos.Three cases of granular cell myoblastoma occurring in the Igbos of nigeria are reported. In this ethnic group the tumor has shown several typical features as follows: it is rarely diagnosed preoperatively; it is found more frequently in the oral cavity and breast than in most other sites; and it is in the maxilla of girls that it usually presents congenitally. A unique presentation in this ethnic group occurred in the perineum. The lesion found in this site appears to be the first to be reported in the literature.- - - - - - - - - - ranking = 21.769876158372keywords = oral cavity, cavity (Clic here for more details about this article) |
8/8. Bilateral granular cell tumors of the posterior mediastinum.Granular cell tumors are uncommon and generally benign lesions that are commonly accepted to be of Schwann cell origin. These tumors occur most frequently in the skin and oral cavity and are generally asymptomatic. However, when signs and symptoms occur, they are relative to the organ or site involved. The histological features are distinct. Surgical resection is curative in almost all cases, with only rare local recurrences. We report a case of symptomatic bilateral granular cell tumors arising in the posterior mediastinum.- - - - - - - - - - ranking = 21.769876158372keywords = oral cavity, cavity (Clic here for more details about this article) |