1/29. Progressive changes in the fluorescein and indocyanine green angiogram in acute idiopathic maculopathy.AIMS/BACKGROUND: To report progressive changes in the fluorescein and indocyanine green angiograms of a patient with acute idiopathic maculopathy (AIM). methods: Over a two-year period, the patient underwent repeated ophthalmoscopic examinations and fluorescein (FA) and indocyanine green (ICG) angiography. RESULTS: The patient presented with subretinal neovascularization in his right eye. He developed recurrences after laser photocoagulation and surgical removal of the neovascular complex. One year later, he experienced a sudden loss of vision in his left eye with a maculopathy consistent with AIM. The maculopathy resolved after two weeks with poor vision. During the acute stage, FA showed lobular hyperfluorescence in the early phase and pooling in the late phase of the angiogram. In the resolved stage of the disease, FA showed irregular window defects and blockage. ICG revealed late hyperfluorescence of the macula in the acute stage. In the resolved stage of the disease, early hypofluorescence was noted in the ICG, which persisted throughout the late phase. CONCLUSION: This patient had poor vision in his right eye as a result of subretinal retinal neovascularization and poor vision in his left eye from a severe form of AIM. FA and ICG differed markedly during the acute and resolved stages of AIM. All cases of idiopathic subretinal neovascularization should be carefully evaluated to exclude AIM as the primary disease.- - - - - - - - - - ranking = 1keywords = complex (Clic here for more details about this article) |
2/29. Interferon alpha-2b at low doses as long-term antiangiogenic treatment of a metastatic intracranial hemangioendothelioma: a case report.We describe a case of intracranial haemangioendothelioma in a 20-year old female patient who presented severe neurological symptoms and relapsed after two surgical interventions. The patient was treated with low doses of recombinant interferon alpha-2b (1 MUI three times a week) after surgical resection which led to recovery of daily function and work activity. To our knowledge, this is the ninth patient reported with intracranial hemangioendothelioma, but the only one having diffuse and painful bone metastases resolved by treatment with interferon. After 30 months the patient is free from symptoms and recurrence. The effectiveness shown by recombinant interferon alpha-2b against vascular neoplasms prompted us to look for the possible biological basis of such a property.- - - - - - - - - - ranking = 6.3986273885172keywords = neoplasm (Clic here for more details about this article) |
3/29. Brain metastases of a malignant fibrous histiocytoma presenting as an acute cerebral hemorrhage.Intracranial metastases from malignant fibrous histiocytoma (MFH) are rare, particularly with associated hemorrhage. This article reports one case and presents a review of the literature on this topic. A 55-year-old man presented with acute drowsiness, aphasia and right homonymous hemianopsia and hemiparesis. The first CT scan showed a left occipitoparietal hematoma and the second one, nodular, contrast-enhanced lesions. He had been previously operated on soft tissues MFH. lung metastases developed subsequently. A craniotomy was performed with evacuation of the hematoma and total gross resection of the mass lesions. Microscopic examination disclosed a metastasis from a MFH. Neoangiogenesis, stimulated by angiogenic growth factors, seems to take part in this vascular, stroke-like event. Due to longer survivals of patients harboring systemic sarcomas, these tumors should be considered in the differential diagnosis of intracranial neoplasms, whether hemorrhagic or not. In particular, history of a previous soft tissue or heart tumor associated with lung metastasis should evoke the possibility of MFH metastasis.- - - - - - - - - - ranking = 6.3986273885172keywords = neoplasm (Clic here for more details about this article) |
4/29. Successful antiangiogenic therapy of giant cell angioblastoma with interferon alfa 2b: report of 2 cases.We describe 2 cases of angioblastoma, a rare, destructive pediatric tumor, treated with interferon alfa 2b (IFNalpha2b). The first patient is a 10-month-old male who presented with an ulcerated palatal neoplasm that could not be completely resected. The second is a male neonate with a congenital tumor of the right hand that invaded the hypothenar eminence, destroying the fourth and fifth metacarpals. biopsy in both patients was interpreted as giant cell angioblastoma. Angioblastoma is rare; there is only 1 reported case that necessitated amputation of an upper extremity, also initially recommended for our patient. Because there is little experience with chemotherapy, permission was granted to employ an antiangiogenic regimen of IFNalpha2b. The angiogenic protein, basic fibroblast growth factor (bFGF), was abnormally elevated in both patients. Both patients received IFNalpha2b. In the first child, it was used after incomplete resection, because biopsy-proven tumor was present at the margin and in the nasopharynx. Biopsies 15 months after initiation of IFN2alphab were negative for tumor. Therapy was stopped after 3 years. Eighteen months later, the patient remains disease-free. In the second child, IFNalpha2b was started after debridement of the ulcerated tumor. Over 11 months, the tumor completely regressed and there was bony regeneration of the metacarpals. The fifth digit was amputated because of damage to the metacarpophalangeal joint by the tumor. IFNalpha2b therapy was discontinued after 1 year of treatment, and the child remains disease-free 2 years and 8 months later. In conclusion, this report demonstrates that: 1) a bFGF-overexpressing low-grade tumor can respond to IFNalpha2b in a manner similar to life-threatening infantile hemangiomas, 2) urinary bFGF levels can help guide IFNalpha dosage in such patients, and 3) although bFGF-mediated tumor angiogenesis is inhibited by IFNalpha, physiologic angiogenesis seems to be unaffected.- - - - - - - - - - ranking = 6.3986273885172keywords = neoplasm (Clic here for more details about this article) |
5/29. Gliomatosis cerebri: quantitative proof of vessel recruitment by cooptation instead of angiogenesis.OBJECT: Gliomas are the most common primary brain tumors, many of which (especially astrocytic and oligodendroglial neoplasms) are characterized by diffuse infiltrative growth in the preexisting brain tissue. Gliomatosis cerebri is a rare glial tumor and represents an extreme example of such diffuse infiltrative growth. This growth pattern not only hampers curative treatment but also allows for vessel cooptation rather than tumor angiogenesis as a way of vessel recruitment by the tumor tissue. The goal of this study was to establish the extent to which tumor angiogenesis occurs in gliomatosis cerebri. methods: Computerized image analysis was performed to assess quantitatively two microvascular parameters (vessel density and diameter) in different areas of a brain harboring a gliomatosis cerebri. These regions were the cerebral white and gray matter in which there was a diffuse infiltrative tumor, cerebral white and gray matter in which there was a more compact growth pattern of tumor cells, and normal cerebral white and gray matter. In addition, the authors performed immunohistochemical stainings for blood-brain barrier (BBB) characteristics (Glut-1 and PgP) on samples obtained in these different areas. The results of the quantitative analysis strongly indicated that in gliomatosis cerebri tumor, angiogenesis was completely absent, a finding that is corroborated by the fact that the microvasculature in gliomatosis cerebri persists in exhibiting immunohistochemical characteristics of the BBB. CONCLUSIONS: The results of this study may help resolve the difficulties in radiological detection and delineation of the diffuse infiltrative part of glial brain tumors and put the expectations for antiangiogenic treatment of such tumors into perspective.- - - - - - - - - - ranking = 6.3986273885172keywords = neoplasm (Clic here for more details about this article) |
6/29. Differential diagnosis of spontaneous hyphema associated with central retinal vein occlusion.Spontaneous hyphema refers to a nontraumatic hemorrhage in the anterior chamber. It is uncommon and may result from such conditions as rubeosis iridis, intraocular neoplasms, blood dyscrasias, severe iritis, fibrovascular membranes in the retrolental or zonular area, and vascular anomalies of the iris. A case is presented describing a spontaneous hyphema occurring as a result of iris neovascularization in a patient who suffered from occlusion of the central retinal vein. Spontaneous hyphema and the presenting ocular conditions as they pertain to its occurrence are discussed.- - - - - - - - - - ranking = 6.3986273885172keywords = neoplasm (Clic here for more details about this article) |
7/29. Macula hemorrhage during intraocular surgery.Poor visual acuity after cataract surgery can be an indication of unsuspected exudative macular disease. A subtle, subretinal neovascular complex present before cataract surgery can hemorrhage during the intraocular procedure. Adequate preoperative photocoagulation and proper timing of intraocular surgery can preserve macular function.- - - - - - - - - - ranking = 1keywords = complex (Clic here for more details about this article) |
8/29. meningeal neoplasms associated with cerebral vascular malformations.Two patients with meningeal neoplasms and nearby vascular anomalies are reported. The lesions were excised and histologically confirmed. One patient had a meningotheliomatous meningioma and an arteriovenous malformation involving the right frontal lobe; the other, a hemangiopericytoma and an arteriovenous malformation in the right parietooccipital region.- - - - - - - - - - ranking = 31.993136942586keywords = neoplasm (Clic here for more details about this article) |
9/29. A subretinal neovascular membrane as a complication of endogenous Candida endophthalmitis.A 21-year-old woman developed endophthalmitis and a macular chorioretinal lesion secondarily to a Candida infection. She had been receiving intensive systemic antibiotic and steroid therapy for pelvic inflammatory disease. Blood cultures confirmed a candida albicans septicemia, and amphotericin b was administered intravenously. As the eye inflammation resolved, healing of the chorioretinal lesion was complicated by the development of a subretinal neovascular membrane. The authors hypothesize that the formation of the membrane was related to an inflammatory alteration of the pigment epithelium--Bruch's membrane--choriocapillaris complex. To the authors' knowledge, this is the first such report following a Candida infection of the eye.- - - - - - - - - - ranking = 1keywords = complex (Clic here for more details about this article) |
10/29. Photocoagulation of raised new vessels by long-duration low-energy argon laser photocoagulation--a preliminary study.Direct laser treatment of retinal neovascularisation is indicated when regression has not been brought about by retinal photocoagulation. Current treatment regimens involve multiple laser applications to the neovascular complex. Long-duration low-energy burns have the advantage of slowly heating the tissue without engendering disruption. We report the use of this treatment as a means of occluding the feeder vessels to a neovascular network. The application of argon blue-green laser treatment at 0.1 watt for 60 seconds at two adjacent points on a feeder vessel was found to give rise to permanent vascular occlusion without causing complications.- - - - - - - - - - ranking = 1keywords = complex (Clic here for more details about this article) |
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