1/2. Metastatic renal cell carcinoma versus pancreatic neuroendocrine tumor in von hippel-lindau disease: treatment with interleukin-2.Differentiating between clear cell neuroendocrine tumor (NET) of the pancreas and renal cell carcinoma (RCC) metastatic to the pancreas can be challenging in patients with von hippel-lindau disease (VHL). The clear cell features of both NET and RCC in VHL patients may lead to misdiagnosis, inaccurate staging, and alternative treatment. We present a patient in which this occurred. As clear cell NETs closely resembling metastatic RCC are distinctive neoplasms of VHL and metastatic RCC to the pancreas in the VHL population is rare, careful pathologic examination should be performed prior to subjecting patients to definitive surgical or medical therapies.- - - - - - - - - - ranking = 1keywords = von (Clic here for more details about this article) |
2/2. von hippel-lindau disease presenting as pancreatic neuroendocrine tumour.A 21-year-old woman with a family history of von hippel-lindau disease presented with a mass in the head of the pancreas. light microscopic features of the tumour suggested neuroendocrine differentiation and although it displayed positive immunostaining for the antigens expected in a neuroendocrine neoplasm, S-100 staining was also present. This unusual feature prompted further evaluation by routine and post-embedding protein-A gold immunoelectron microscopy, which demonstrated the presence of neuroendocrine granules. Tumour cell dna content was normal by flow cytometry. Although this patient exhibited no other signs of von hippel-lindau disease, the presence of a pancreatic tumour with neuroendocrine differentiation demonstrated that she was affected. Future surveillance and genetic counselling will be influenced by this diagnosis.- - - - - - - - - - ranking = 0.4keywords = von (Clic here for more details about this article) |