1/16. Nasal chondromesenchymal hamartoma of infancy: the first Japanese case report.The first Japanese case of nasal chondromesenchymal hamartoma, a rare infantile nasal neoplasm, is presented. A 4-month-old Japanese boy was referred to our Centre because of intranasal mass and oculomotor disturbance. Radiological images showed the intranasal tumor extending to the paranasal sinus, orbit, and anterior frontal fossa. Subtotal resection and radiation therapy to residual tumor were performed. There has been no recurrence of the tumor for 13 years. Histologically, the lesion demonstrated admixture of various mesenchymal elements, including cellular spindle cell stroma with occasional myxoid change, nodules of mature/immature cartilaginous tissue, focal osteoclast-like giant cells, and erythrocyte-filled spaces resembling aneurysmal bone cyst. The histology was consistent with the findings presented by McDermott et al. 1986. Immunohistochemically, the spindle cells were positive for vimentin and smooth muscle actin. chondrocytes in the mature cartilaginous tissue were positive for S-100 and vimentin; chondrocytes in the immature cartilaginous tissue were positive for S-100, vimentin, and smooth muscle actin. Ultrastructurally, the spindle cells showed features of either fibroblast or myofibroblast.- - - - - - - - - - ranking = 1keywords = giant (Clic here for more details about this article) |
2/16. Sinonasal tract eosinophilic angiocentric fibrosis. A report of three cases.Eosinophilic angiocentric fibrosis (EAF) is a rare submucosal fibrosis without a well-developed differential diagnosis. Three cases of sinonasal tract EAF were identified in 2 women and 1 man, aged 49, 64, and 28 years, respectively. The patients experienced a nasal cavity mass, maxillary pain, or nasal obstructive symptoms of long duration. The process involved the nasal septum (n = 2), nasal cavity (n = 1), and/or the maxillary sinus (n = 1). There was no evidence for wegener granulomatosis, churg-strauss syndrome, Kimura disease, granuloma faciale, or erythema elevatum diutinum. Histologically, the lesions demonstrated a characteristic perivascular "onion-skin" fibrosis and a full spectrum of inflammatory cells, although eosinophils predominated. necrosis and foreign body-type giant cells were not identified. Surgical excision was used for all patients, who are all alive but with disease at last follow-up. Sinonasal tract EAF is a unique fibroproliferative disorder that does not seem to have systemic associations with known diseases. The characteristic histomorphologic features permit accurate diagnosis.- - - - - - - - - - ranking = 1keywords = giant (Clic here for more details about this article) |
3/16. calcium oxalate granuloma of the nose of a chronically dialysed nephritic patient.The patient was a 54-year-old woman who had been suffering from chronic tubulo-interstitial nephritis for about seven years, requiring haemodialysis. More recently, she developed a polypoid mass in the left nasal cavity causing discomfort on breathing and slight epistaxis. The tumour was of gritty consistency and measured 28 x 8 x 5 mm. microscopy showed a lobulated almost cystic structure composed of granulation tissue with comparatively few plasma cells and many multinucleated giant cells lining the spaces filled with crystalline deposits of calcium oxalate.- - - - - - - - - - ranking = 1keywords = giant (Clic here for more details about this article) |
4/16. Presumably entomophthoramycosis in an hiv-infected patient: the first in thailand.The authors reported the case of a symptomatic hiv-infected woman with a slowly progressive infiltrative lesion which invaded in and around the nasal cavity over a 6-month period. physical examination showed erythematous to violaceous plaques at the nasal and malar areas. Swelling of the inferior turbinate was noted in the right nare. skin biopsy of the involved area revealed multiple nonseptate, broad, thin-walled hyphae within giant cells and granulomata. Entomophthoramycosis was diagnosed based on clinical features and histopathology. She was treated with intravenous amphotericin b for two weeks, followed by oral itraconazole 400 mg daily. At six months there was complete resolution of all lesions.- - - - - - - - - - ranking = 1keywords = giant (Clic here for more details about this article) |
5/16. oral manifestations of paracoccidioidomycosis. Report of 21 cases from argentina.The present study describes 21 Argentinian patients living in the province of Corrientes, who had developed oral manifestations due to paracoccidioides brasiliensis infection. Of these, 20 patients were men and one a woman. patients were of an average age of 39 years (range 25 to 72 years). Approximately, 76.2% of the patients were farmers. Gingival lesions were observed in 76%. Also, the tongue (71%) and the lips (62%) were frequently affected. Cytological smears and histopathology showed the characteristic fungal cells with the characteristic granulomatous inflammatory reaction consisting of lymphocytes, epithelioid cells and giant cells of the Langhans type. All patients except one had detectable pulmonary involvement. Therapy consists of long-term administration of itraconazole. oral manifestations of paracoccidioidomycosis are characteristic in their clinical presentation. early diagnosis and adequate therapy may prevent extensive tissue destructions. Long-term follow-up is mandatory.- - - - - - - - - - ranking = 1keywords = giant (Clic here for more details about this article) |
6/16. Diagnostic difficulties in a case of isolated sarcoidosis of the nose and sinuses.sarcoidosis still remains a diagnosis of exclusion. It is unusual for the disease to be localised in the nose and sinuses and to manifest its symptoms in this site; the diagnosis in such cases is rather a difficult task. There is no symptom pathognomonic of the disease. A major role in the diagnosis of sarcoidosis is played by histologic evidence on the basis of which additional tests can be used. We present a case of primary sarcoidosis of the nose and sinuses which involved the orbit and had non-specific symptoms in the sinonasal region. The diagnosis of sarcoidosis was made ultimately only after decalcification of sample material taken from the ethmoidal labyrinth. Interspersed among the bone trabeculae there were the typical epithelioid cellular granulomas composed of epithelioid cells with round nuclei and prominent nucleoli, Langhans'-type giant cells, and a tender rim of chronic inflammatory infiltrate in the periphery. After initial beneficial response to the administered cortisone therapy (40 mg prednisolone daily for 6 months and then a daily maintenance dose of 10 mg) the control examination showed that the peri- and retrobulbar infiltrate persisted and the eye symptoms recurred. We therefore increased the dose and proceeded to a pulse therapy (120 mg of urbason daily and a daily maintenance dose of 30 mg). At present the patient is still receiving this therapy which has reduced as a result the local manifestations but Cushing's syndrome has developed as a side effect.- - - - - - - - - - ranking = 1keywords = giant (Clic here for more details about this article) |
7/16. A case of giant nasal pyogenic granuloma gravidarum.Pyogenic granuloma gravidarum occurs as oral or nasal lesions in approximately 5% of pregnant women. nasal mucosa is an unusual site for this lesion with few cases reported in the literature. A case of giant nasal pyogenic granuloma gravidarum that required radical excision through an open rhinotomy after superselective embolization is described. The patient had a good cosmetic result and a satisfactory airway when she was seen for follow-up 1 year after surgery. Giant pyogenic granuloma gravidarum is best managed with a multidisciplinary approach involving radical excision after preoperative superselective embolization for safe and complete removal of the lesion.- - - - - - - - - - ranking = 5keywords = giant (Clic here for more details about this article) |
8/16. nasal septum giant pyogenic granuloma after a long lasting nasal intubation: case report.The authors present a case of Pyogenic Granuloma (PG) arising from the nasal septum in the posterior nasal cavity of a patient male sex, caucasian, 32 years old, with a previous history of cranioencephalic trauma, several neurosurgeries for different subsequent neurological problems and the use of a nasogastric tube for feeding (nasal intubation) during 30 days. He underwent surgery in St. Vincent de Paul Hospital (Rio de Janeiro) on May 18, 1993, for the tumor removal and straightening of the nasal septum. Under endoscopic guidance the complete excision of the tumor mass was perfectly done thanks to the excellent exposure of the lesion, provided by the enlarged telescopic view, and the wide access afforded by the septum straighttening plus the cartilaginous septum mobilization through the maxilla-premaxilla approach of Cottle, allied to the lateralization and volume reduction of the right inferior nasal concha, simultaneously performed, thus making lateral rhinotomy or "degloving" unnecessary. The patient is until now (2004) completely free of the lesion operated on. This is the first report in the literature of such a lesion associated to nasal intubation as the triggering agent.- - - - - - - - - - ranking = 4keywords = giant (Clic here for more details about this article) |
9/16. Giant rhinolith: a case report.A rhinolith is a stone that forms in the nose. It occurs as a result of the solidification of mucus and nasal debris by mineral salts, calcium, magnesium phosphate and carbonate. It can be seen on radiographs as a radiopaque object in the nasal fossa and may be confused with several pathologic entities that will call for more invasive surgical procedures. We present the first case of a giant rhinolith, possibly arising from aspergillosis, and discuss its clinical and radiologic features.- - - - - - - - - - ranking = 1keywords = giant (Clic here for more details about this article) |
10/16. Giant cell reparative granuloma presenting as a midline nasal mass.Giant cell reparative granuloma (GCRG) is an uncommon entity that has been reported in all areas of the head and neck. It must be distinguished from true giant cell tumors, brown tumors of hyperparathyroidism, aneurysmal bone cysts, and fibrous dysplasia. It responds well to surgical debulking and curettage and has a benign clinical course. We describe a case report of a GCRG presenting as a midline nasal mass and review the pertinent English language literature.- - - - - - - - - - ranking = 1keywords = giant (Clic here for more details about this article) |
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