1/7. Cutaneous alternariosis in a cardiac transplant recipient.A 55-year-old male cardiac transplant recipient presented with cutaneous nodules on the limbs caused by alternaria alternata. Oral fluconazole 200 mg daily for 3 weeks was ineffective. itraconazole 100 mg oral daily was ceased when hyperglycaemia developed. Individual lesions were successfully treated with either curettage and cautery or double freeze-thaw cryotherapy. alternaria spp. are ubiquitous fungal saprophytes which may cause cutaneous infections particularly in immunocompromised patients.- - - - - - - - - - ranking = 1keywords = alternariosis (Clic here for more details about this article) |
2/7. Sporotrichoid phaeohyphomycosis due to alternaria infectoria.We describe a cardiac transplant patient who had human cutaneous alternariosis with a sporotrichoid distribution of skin lesions. In this patient identification of the causative organism alternaria infectoria was achieved by sequencing the rDNA internal transcribed spacer domain. Treatment with itraconazole led to clinical resolution within 4 months.- - - - - - - - - - ranking = 0.47514577042315keywords = alternariosis, cutaneous alternariosis (Clic here for more details about this article) |
3/7. Relapsing cutaneous alternariosis in a kidney transplant recipient cured with liposomal amphotericin b.An immunosuppressed patient who presented with unusual clinical signs of cutaneous alternariosis, including papular, nodular and verrucous lesions of the forearms, is reported. In spite of continuous treatment with oral itraconazole for 6 months, a large, progressive, necrotic ulcer appeared on the patient's left leg. Liposomal amphotericin b was then administered (total dose, 750 mg) with excellent clinical results.- - - - - - - - - - ranking = 2.3757288521157keywords = alternariosis, cutaneous alternariosis (Clic here for more details about this article) |
4/7. Cutaneous alternariosis in association with scabies or iatrogenic Cushing's syndrome.Cutaneous alternariosis is rare. Most infections occur in immunocompromised hosts. We report the first three cases in taiwan. The patients were elderly farmers residing in Tainan. They developed indolent, erythematous, ulcerated or crusted papules, plaques or pustules over the extensor aspect of the forearms or hands. Pure colonies of alternaria sp were isolated from biopsy specimens in each case. The diagnosis was confirmed by detecting pleomorphic fungal elements in the dermis within suppurative, granulomatous infiltrates. All three patients were immunocompromised. They showed a negative reaction to an intradermal test of seven common antigens. Cases 2 and 3 had iatrogenic Cushing's syndrome. Cases 1 and 3 had extensive scabies, which in Case 1 was of the Norwegian type. To the best of our knowledge, scabies associated with alternariosis has not been reported previously. The infection showed spontaneous regression in Case 1; in Case 2, it resolved after seven weeks of intralesional amphotericin b at a dose of 1 mg/mL twice a week.- - - - - - - - - - ranking = 1.5keywords = alternariosis (Clic here for more details about this article) |
5/7. Cutaneous alternariosis in a liver transplant recipient.We describe the case of a liver transplant patient with a cutaneous alternariosis due to alternaria infectoria. Cutaneous lesions regressed with the decrease in daily doses of immunosuppressors. The skin lesion remains cicatricial after one year of follow-up.- - - - - - - - - - ranking = 1.4751457704231keywords = alternariosis, cutaneous alternariosis (Clic here for more details about this article) |
6/7. Cutaneous alternariosis: a rare chromohyphomycosis. Report of a case.A 66-year-old woman presented 3 groups of scaly granulomatous lesions on the right forearm and elbow of six months duration. Direct examination of the scales showed hyphae and culture in lactrimel medium grew alternaria sp. considered a contaminant. No improvement was observed after six months of treatment with oral griseofulvin. A second culture using half of a biopsy grew alternaria sp. again and in histologic examination short pigmented fragments of hyphae surrounded by a granulomatous reaction were seen in the derma. The patient had marked improvement after treatment with erythromycin per os and miconazole topically; an atrophic scar remained as the only sign of the fungal infection.- - - - - - - - - - ranking = 1keywords = alternariosis (Clic here for more details about this article) |
7/7. Cutaneous alternariosis: role of corticosteroid-induced cutaneous fragility.alternaria is a very common and saprophytic fungus. Cutaneous infection is rare and about 71 cases have been described, mainly in europe in immunocompromised hosts. We report a case of dermal alternariosis occurring in a woman treated with corticosteroids for dermatomyositis. The cutaneous lesion consisted of an erythematous and scaly plaque on the leg measuring 2 x 2 cm. Cutaneous biopsy showed hyphae and round inclusions stained with PAS and Gomori-Grocott within a polymorphous granuloma. Cultures of cutaneous biopsies grew alternaria sp. HIV1 and HIV2 serology was negative. The patient was treated by local excision and corticosteroids were decreased. One-year follow-up showed no recurrence. Cutaneous alternariosis is an opportunistic infection. the disease has been described mainly in patients treated with systemic corticosteroids (39 cases out of the 71 reported cases) or local corticosteroids (3/71) and in patients suffering from Cushing's syndrome (7/71) but rarely in hiv-infected patients (3/71). Cutaneous fragility induced by hypercorticism is an important cofactor permitting direct inoculation from the environment.- - - - - - - - - - ranking = 1.5keywords = alternariosis (Clic here for more details about this article) |