1/5. Hemorrhagic diathesis in a carrier of hemophilia b.A carrier of hemophilia b was found to have an unusually low factor ix level of 13 per cent. Her history of previous bleeding and the hospital course following elective dental extractions were consistent with a mild hemorrhagic diathesis. The patient is a member of a rare kindred of hemophiliacs. The mean level of factor ix in 12 carriers in this kindred was 42 per cent, with a range of 13 to 100 per cent. This patient represents the sixth reported case in which a female carrier of factor ix deficiency was symptomatic.- - - - - - - - - - ranking = 1keywords = diathesis (Clic here for more details about this article) |
2/5. Prostatic carcinoma presenting as a haemorrhagic diathesis after dental extraction.A fatal case of disseminated intravascular coagulation, secondary to a previously undiagnosed prostatic carcinoma, occurred following tooth extraction. The nature of the condition and its variable presentation are discussed, as well as problems in diagnosis and management.- - - - - - - - - - ranking = 39.009890184444keywords = haemorrhagic diathesis, diathesis (Clic here for more details about this article) |
3/5. DDAVP: review of indications for its use in the treatment of factor viii deficiency and report of a case.Classic hemophilia or factor viii deficiency is a recessive, sex-linked bleeding diathesis. The primary clinical problem is hemorrhage, which can be severe and often life threatening, even in the presence of only minor trauma. In the past this inadequate hemostasis has been treated with transfusions of cryoprecipitate, fresh frozen plasma, or commercially prepared factor viii concentrate. Unfortunately, such treatment carries with it a number of risks, including the development of hepatitis b or hemolytic anemia and the formation of anti-factor viii antibodies. Because of hemorrhage severity and the risks of conventional treatment, elective surgery in general and oral surgery in particular have often been neglected in patients with hemophilia. This article reviews a drug, 1-desamino-8-d-arginine (DDAVP), heretofore not discussed in the dental literature, and reports on its use in conjunction with epsilon-aminocaproic acid (EACA), a synthetic antifibrinolytic agent, in the surgical dental treatment of a patient with hemophilia a. The results suggest that certain dental surgical procedures can be performed in the presence of subclinical and mild hemophilia without conventional factor viii replacement therapy with its associated costs and risks.- - - - - - - - - - ranking = 0.2keywords = diathesis (Clic here for more details about this article) |
4/5. Postsurgical hemorrhage resulting from a drug-induced circulating anticoagulant: report of case.A case of circulating anticoagulant resulting in persistent postoperative bleeding has been reported. All clotting factors were normal when the patient's plasma was tested in a high dilution. Unlike previous reports of this type of coagulation inhibitor, the hemorrhagic diathesis was clinically severe in comparison with the mildly abnormal in vitro tests. Many unknowns remain: the chemical nature of this anticoagulant; the time needed to return to normal coagulation levels; the frequency and severity of drug-induced anticoagulation; and the dose and duration of usage of medications resulting in circulating anticoagulants. In retrospect, the only clinical evidence suggestive of a coagulation problem in this case was a marginally elevated partial thromboplastin time. In our opinion, a preoperative coagulation screening, consisting of prothrombin time, partial thromboplastin time, platelet count, and template bleeding time, may help to prevent serious postoperative hemostatic complications.- - - - - - - - - - ranking = 0.2keywords = diathesis (Clic here for more details about this article) |
5/5. urticaria haemorrhagica profunda.Substantial subcutaneous haemorrhage without preceding trauma or underlying bleeding disorder is a rare occurrence in dermatological practice, essentially restricted to early childhood (acute haemorrhagic oedema of childhood). We report an adolescent with a morphologically unique bleeding manifestation. A 16-year-old boy presented with two episodes of massive subcutaneous haemorrhage in association with urticarial vasculitis. There was no history of preceding trauma or haemorrhagic disorder. Haemorrhage was observed in areas typically affected by angioedema, such as the periorbital, perioral, lingual, sublingual and laryngeal areas. history revealed an atopic diathesis with hay fever and examination showed alopecia areata. An antinuclear antibody titre and the presence of lupus anticoagulant indicated transient antiphospholipid antibodies. As urticaria corresponds to urticaria profunda angioedema, we hypothesize a pathophysiological relationship between superficial urticarial vasculitis and the deep variant of urticarial vasculitic disease, leading to the unique morphology present in our patient.- - - - - - - - - - ranking = 0.2keywords = diathesis (Clic here for more details about this article) |