1/37. Endocrine cell micronests in an ovarian mucinous cystadenofibroma: a mimic of microinvasion.An ovarian mucinous cystadenofibroma with peculiar neuroendocrine cell micronests is described in a 59-year-old Japanese woman. Aggregates of epithelial cells resembling microinvasive carcinoma cells were scattered throughout the adenofibromatous area. These micronests were composed of small uniform cells with argentaffin and argyrophil granules. Numerous small cells with neuroendocrine granules were also seen within mucinous glands. This is the first report of neuroendocrine micronests in an ovarian neoplasm, a finding that should be distinguished from microinvasion.- - - - - - - - - - ranking = 1keywords = adenofibroma (Clic here for more details about this article) |
2/37. Tubulocystic ovarian clear cell carcinoma with abundant fibrous stroma: malignant clear cell adenofibroma.We report a case of tubulocystic ovarian clear cell carcinoma (OCCC) with abundant fibrous stroma associated with an endometriotic cyst. Most OCCC show a small amount of fibrous stroma; however, the tumor presented in this case had abundant stroma, that qualifies it as a malignant clear cell adenofibroma. This unusual type of clear cell carcinoma may be misinterpreted as a benign lesion or as metastatic carcinoma on frozen section. In permanent sections, the stromal invasive foci are focal, small and subtle. Therefore, extensive sampling of the specimen to search for evidence of invasion is recommended for a fibrous ovarian tumor that appears benign on gross examination.- - - - - - - - - - ranking = 0.83333333333333keywords = adenofibroma (Clic here for more details about this article) |
3/37. Benign, borderline, and malignant endometrioid neoplasia arising in endometriosis in association with tamoxifen therapy.tamoxifen therapy may result in a variety of endometrial proliferative lesions, including adenocarcinoma, and as recently suggested, proliferative changes within endometriosis. This report describes an endometrioid adenocarcinoma arising in ovarian endometriosis in a patient taking tamoxifen. There were also foci of benign and borderline endometrioid adenofibroma in the same ovary and a synchronous endometrioid endometrial adenocarcinoma in the uterus. The spectrum of benign, borderline, and malignant endometrioid neoplasia arising within endometriosis suggests that tamoxifen, as a result of its estrogenic effects, may cause proliferative and, in rare instances, malignant changes in endometriosis.- - - - - - - - - - ranking = 0.16666666666667keywords = adenofibroma (Clic here for more details about this article) |
4/37. Ovarian cystadenofibromas: characteristic magnetic resonance findings with pathologic correlation.Ovarian cystadenofibroma is a benign tumor and may appear as a multilocular cystic mass with solid nodular components mimicking malignant ovarian tumor. Preoperative diagnosis is required to avoid excess surgical procedure. We report characteristic magnetic resonance imaging (MRI) findings of 2 cases with pathologic correlation. On T2-weighted images, the solid components of the tumors showed very low intensity, in which very high intense tiny cysts were present reflecting dense fibrous stromal proliferation with scattered small cystic glandular structures. This "black sponge"-like appearance was considered to be diagnostic.- - - - - - - - - - ranking = 0.83333333333333keywords = adenofibroma (Clic here for more details about this article) |
5/37. A menopausal woman with mullerian agenesis, a leiomyoma, an inguinal hernia, and cystadenofibromas.BACKGROUND: Mullerian agenesis, the second most common cause of primary amenorrhea, affects 1 in 4,000 to 10,000 women. Although the majority of these women have complete absence of the uterus, a small percentage can have a rudimentary uterus. CASE: A menopausal nulligravida with known mullerian agenesis developed a large pelvic mass and an inguinal hernia. The patient underwent an exploratory laparotomy, which revealed a large leiomyoma growing from a small rudimentary uterus, an indirect inguinal hernia, and bilateral benign serous cystadenofibroma. CONCLUSION: women with mullerian agenesis and rudimentary uteri can develop gynecologic pathology similar to women with normal genital tracts.- - - - - - - - - - ranking = 0.83333333333333keywords = adenofibroma (Clic here for more details about this article) |
6/37. Neurofibromatosis of atypical presentation.Neurofibromatosis (NF) is considered to be a heterogeneous neuroectodermal disease clinically defined by the presence of neurofibromas, multiple cafe-au-lait spots, intertriginous freckles and Lisch nodules. mosaicism explains atypical presentations of the disease. Early mutations, before tissue differentiation, give rise to generalized disease. We report an atypical presentation of neurofibromatosis with an unusual distribution of neurofibromas, a peculiar, clinically and pathologically, neurofibroma on the trunk and the association with an ovarian serous cystoadenofibroma.- - - - - - - - - - ranking = 0.16666666666667keywords = adenofibroma (Clic here for more details about this article) |
7/37. Cystic clear cell tumor of borderline malignancy of the ovary lacking fibromatous components: report of two cases and a possible new histological subtype.BACKGROUND: All of the ovarian borderline clear cell tumors ever reported had, without exception, an adenofibromatous pattern. CASE: We report two cases of borderline cystic clear cell tumor of the ovary without apparent invasive lesions or adenofibromatous components. CONCLUSION: This is the first report of cystic clear cell tumors of borderline malignancy, indicating a possible new histological subtype.- - - - - - - - - - ranking = 0.33333333333333keywords = adenofibroma (Clic here for more details about this article) |
8/37. Ovarian serous cystadenofibroma with stromal sex cord elements: report of a unique case.This report describes an ovarian serous cystadenofibroma, in a postmenopausal woman, which exhibited extensive sex cord differentiation, in the form of solid and hollow tubules resembling Sertoli cell elements, within the stroma. The sex cord elements, which were located just beneath the epithelium, were positive with both alpha inhibin and calretinin and negative with epithelial membrane antigen. They were also CD56 positive but negative with other neuroendocrine markers. True sex cord structures or sex cord-like elements have been described in ovarian adenosarcomas and pure stromal tumors, especially fibromas. However, as far as we are aware, these elements have not been reported in a serous cystadenofibroma. The endometrium exhibited simple hyperplasia, perhaps secondary to estrogenic activity of the sex cord elements. We discuss the significance of CD56 positivity of the sex cord elements.- - - - - - - - - - ranking = 1keywords = adenofibroma (Clic here for more details about this article) |
9/37. Treatment for infertility and risk of invasive epithelial ovarian cancer--a case report.A 30-year-old women was admitted to the Institute of gynecology and obstetrics, Clinical Center of serbia in April 2004 with the following diagnosis: adnexal mass soon after in vitro fertilization. Her history revealed salpingo-oophorectomy for mucinous cystadenofibroma of the left ovary eight years before and cystectomy of the right ovary three years before. At admission, the most remarkable findings were high temperature and elevated white blood cells with erythrocyte sedimentation rate. After the antibiotic treatment, laparatomy was performed and a multilocular right adnexal tumor was found. The right salpingo-oophorectomy was performed and pathological diagnosis was mucinous ovarian adenocarcinoma. Two weeks later, radical surgery was carried out and chemotherapy was applied. There is an urgent need for clear interpretation of the link between ovarian stimulation and ovarian cancer. An association between ovarian stimulation treatment and ovarian cancer has still not been completely proven.- - - - - - - - - - ranking = 0.16666666666667keywords = adenofibroma (Clic here for more details about this article) |
10/37. Malignant endometrioid cystadenofibroma of the ovary.Malignant endometrioid cystadenofibroma is recognized as a distinct category of epithelial ovarian cancer and yet is rarely reported. Three patients from the University of north carolina experience are described to emphasize similarities between this unusual tumor and common epithelial ovarian cancer with respect to clinical behavior, surgical staging, and treatment.- - - - - - - - - - ranking = 0.83333333333333keywords = adenofibroma (Clic here for more details about this article) |
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