1/5. Signet ring stromal tumor of the ovary occurring in conjunction with brenner tumor.OBJECTIVE: A case is presented of a single ovarian mass that had elements of both signet ring stromal tumor of the ovary and brenner tumor. methods: The histologic features and the results of histocytochemical, immunohistochemical, and electron microscopic studies are presented. RESULTS: The signet ring component of the mass demonstrated features consistent with the few other cases previously reported. A positive immunohistochemical stain for the peptide hormone inhibin provides additional evidence for an ovarian stromal origin for this tumor. CONCLUSION: The tumor produced no hormonally related symptoms and has shown no evidence of recurrence. Signet ring stromal tumor of the ovary is an uncommon benign tumor that may be confused with metastatic signet ring carcinoma. The significance of the signet ring cells is not certain. Their association with brenner tumor has not been previously described.- - - - - - - - - - ranking = 1keywords = brenner (Clic here for more details about this article) |
2/5. Proliferating Brenner tumour of ovary--a case report.Transitional cell tumours or Brenner tumours of ovary are uncommon neoplasms. Out of all the Brenner tumours less than 2% are either proliferating or malignant type. Borderline or malignant tumours occur in women who are on an average 10 years older than those with benign tumours. It is essential to categorise these tumours as benign, borderline or malignant type as the biologic behaviour and choice of surgery differs in all of the three categories. The gross and microscopic findings of a proliferating brenner tumour are reported here.- - - - - - - - - - ranking = 1.2996819837156keywords = brenner tumour, brenner (Clic here for more details about this article) |
3/5. Coexistence of brenner tumor and struma ovarii: case report.BACKGROUND: There has been controversy regarding the histogenesis of Brenner tumors. It is generally accepted that Brenner tumors are derived directly from ovarian surface epithelium, which undergoes metaplasia to form the typical urothelial-like components, whereas some investigators assume that Brenner tumors arise from immature germ cells. CASE: We describe a well-documented case of the coexistence of struma ovarii regarded as a form of teratoma and brenner tumor in the same ovary. Immunohistologically, not only columnar cells of thyroid follicles, but also transitional cells of Brenner nests were positive for thyroglobulin. CONCLUSIONS: In the present case, Brenner tumors and thyroid elements coexisted and were positive for thyroglobulin. While there is strong evidence that pure Brenner tumors originate mostly from the ovarian surface, at least Brenner tumors associated with teratomatous elements may have a germ cell origin.- - - - - - - - - - ranking = 1keywords = brenner (Clic here for more details about this article) |
4/5. A case of virilizing brenner tumor in a postmenopausal woman with stromal androgenic activity.Although there are several reports of brenner tumor showing estrogen activities, it is an extremely rare cause of androgen excess leading to virilism, and the source or mechanism of its androgen production is also unknown at present. A 74-year-old woman presented with lower abdominal pain and increased facial hair growth of 6-month duration. Bilateral ovarian tumors were detected, and her serum testosterone (1.7 ng/mL) and estradiol (75 pg/mL) levels were elevated. Bilateral salpingo-oophorectomy was performed. The ovarian tumors were diagnosed as benign brenner tumor associated with fibrothecoma-like and luteinized stromal cells. Postoperatively, the serum testosterone and estradiol levels decreased. Immunohistochemically, fibrothecoma-like stromal cells were positive for cytochrome P-450 aromatase, which catalyzes the conversion from androgen to estrogen, and negative for c-Jun protein, which has recently reported to attenuate estrogen biosynthesis by directly down-regulating transcription of the aromatase gene. On the other hand, luteinized stromal cells were negative for cytochrome P-450 aromatase and positive for c-Jun protein. It is suggested that androgen is produced mainly in the luteinized stromal cells, because androgen is not converted to estrogen caused by suppression of aromatase biosynthesis by c-Jun.- - - - - - - - - - ranking = 1keywords = brenner (Clic here for more details about this article) |
5/5. Cystosarcoma phyllodes metastatic to a brenner tumor of the ovary.A patient had cytosarcoma phyllodes that developed metastases to bone and to a brenner tumor of the ovary. The original breast tumor was reported as benign, but the patient died of metastases four months following mastectomy. The rapid growth in the ovary may have been due to estrogenic stroma in the brenner tumor. This is the first report, to our knowledge, of cystosarcoma phyllodes metastasizing to another tumor.- - - - - - - - - - ranking = 1keywords = brenner (Clic here for more details about this article) |