1/329. Primary angiosarcoma of the ovary: a case report and review of the literature.INTRODUCTION: Gynecological sarcomas are rare and have a poor prognosis. Uterine sarcomas are most common accounting for 4% of all uterine tumors. Ovarian sarcomas are less frequent and are usually carcinosarcomas. CASE REPORT: A previously healthy 40-year-old G2P2 presented for evaluation of 72 h of right upper quadrant pain and shortness of breath. A malignant right pleural effusion, ascites, and adnexal mass were found. Surgical staging and suboptimal debulking revealed pure angiosarcoma of the ovary Stage IV. DISCUSSION: There are 12 cases of ovarian angiosarcoma reported in the literature. Ten of these cases presented in advanced stages with survivals of 2-30 months. Various chemotherapy regimens have been tried on these tumors including the most recent recommendation of MAID (mesna, doxorubicin, ifosfamide, and dacarbazine) and prognosis remains poor. Our patient underwent elective right pleurodesis via video-assisted thorascopic surgery under local anesthesia for an early recurrent right pleural effusion and subsequently began MAID chemotherapy.- - - - - - - - - - ranking = 1keywords = sarcoma (Clic here for more details about this article) |
2/329. osteosarcoma arising in a mature cystic teratoma of the ovary.A 80-year old woman was found to have an osteosarcoma arising within a mature cystic teratoma of the ovary. To the Author's knowledge, this is the fourth reported case of osteosarcoma arising within a teratoma.- - - - - - - - - - ranking = 0.6keywords = sarcoma (Clic here for more details about this article) |
3/329. Malignant mixed mesodermal tumor arising in a benign cystic teratoma.The occurrence of sarcoma in a benign cystic teratoma is very rare. We report the first poorly differentiated, malignant mixed mesodermal tumor with a component of rhabdomyosarcoma to arise in a benign cystic teratoma of the ovary. The tumor was staged as FIGO IC due to capsule invasion. Although combination chemotherapy of cisplatin, ifosfamide and mesna, was instituted, the disease took a rapidly progressive course. After an unusual metastasis to the scapula was detected, the patient deteriorated and died in the forth postoperative month.- - - - - - - - - - ranking = 0.2keywords = sarcoma (Clic here for more details about this article) |
4/329. MR findings in ovarian granulocytic sarcoma.Granulocytic sarcoma (chloroma) is a mass of malignant myeloid precursor cells in an extramedullary location. The female genital tract, including the ovary, may be the first site for clinical manifestation of granulocytic sarcoma. The MR findings are reported in a case of ovarian granulocytic sarcoma which preceded acute myelogenous leukaemia. Granulocytic sarcoma shows a mixed cystic and solid adnexal mass with intermediate signal intensity on T1 weighted images and hypointensity on T2 weighted images.- - - - - - - - - - ranking = 0.8keywords = sarcoma (Clic here for more details about this article) |
5/329. Fine-needle aspiration cytology of malignant fibrothecoma of the ovary.Fibrothecomas are common, but their malignant counterpart is extraordinarily rare. To the best of our knowledge, this is the first report on the cytologic features of malignant fibrothecoma. We had an opportunity to study it because the 70-yr-old woman refused initial surgery until the tumor reached 22 cm in size and weighed 1, 500 gm. A CT-guided fine-needle aspiration biopsy was obtained from a 5 cm left pelvic mass, which was the second recurrence within 5 yr. The smears showed large fragments of tightly packed, small, oval cells with scanty, eccentric blue cytoplasm (Diff-Quik stain), and finely granular chromatin with small central nucleoli (Ultrafast Papanicolaou stain), transected by delicate blood vessels. The tumor resembled well-differentiated carcinoma, low-grade endometrial stromal sarcoma, and other small oval cell gynecologic neoplasms. cytodiagnosis of nonepithelial ovarian neoplasms can be difficult. However, it is not impossible, especially for recurrent tumors with previously established histodiagnosis. Diagn. Cytopath. 21:284-286, 1999.- - - - - - - - - - ranking = 0.1keywords = sarcoma (Clic here for more details about this article) |
6/329. Myofibroblastoma of the ovary: report of a case.We report an unusual case of an ovarian tumor arising in a 22-year-old female that showed histologic, immunohistochemical, and ultrastructural features of myofibroblastic differentiation. The mass was found incidentally and upon excision was 9.0 cm in its greatest dimension and almost entirely replaced the left ovary. The patient is alive without evidence of disease 21 months after excision. Histologically, the tumor was encapsulated and composed of cytologically bland spindled cells arranged into a variety of patterns, similar to those found in both solitary fibrous tumor and hemangiopericytoma. Immunohistochemically, the cells stained strongly for smooth muscle actin and muscle-specific actin, with only focal and weak staining for CD34. Stains for S-100 protein, desmin, and AE1/AE3 were negative. Ultrastructurally, the neoplastic cells showed clear-cut evidence of myofibroblastic differentiation. The differential diagnostic considerations, including solitary fibrous tumor and hemangiopericytoma, are discussed.- - - - - - - - - - ranking = 0.0019229017846376keywords = spindle (Clic here for more details about this article) |
7/329. Mucinous cystadenocarcinoma in combination with hemangiosarcoma in the ovary.The ovary is the sixth most frequent site of cancer in women in denmark with an incidence of approximately 600 cases per year. Carcinomas predominate whereas sarcomas are rare. We describe a case of the combination mucinous cystadenocarcinoma and hemangiosarcoma in a 37-year old woman, who had a right-sited oophorectomy because of a cyst. Clinically there was no suspicion of malignancy. The macro- and microscopic findings are described as well as the immunohistochemical stainings performed to confirm the diagnosis. The case shows the importance of careful sampling at the macroscopic examination, especially from areas with a striking appearance.- - - - - - - - - - ranking = 0.6keywords = sarcoma (Clic here for more details about this article) |
8/329. Treatment of primary pure angiosarcoma of ovary with multiple lung metastases: a case report.Angiosarcomas rarely involve the female genital tract. There have only been sporadic case reports of angiosarcomas of the cervix, uterus, vagina, parametrium, broad ligament and pelvis, and only 11 well-documented case reports of primary ovarian angiosarcoma in the English language literature to date. We present a case of primary pure ovarian angiosarcoma with lung metastasis that had partial response after chemotherapy with adriamycin and ifosfamide. But pulmonary hemorrhage and respiratory failure resulted in her death 7 months after initial diagnosis.- - - - - - - - - - ranking = 0.8keywords = sarcoma (Clic here for more details about this article) |
9/329. Peritoneal osteosarcoma following irradiation therapy of ovarian cancer.A peritoneal osteosarcoma occurring after irradiation therapy for cystadenocarcinoma of ovary is described. Only 6 cases of postradiation extraosseous osteosarcomas have been reported and none of them have arisen within the peritoneum. The clinical presentation and histopathology of this unusual tumor is presented with a review of the literature.- - - - - - - - - - ranking = 0.6keywords = sarcoma (Clic here for more details about this article) |
10/329. carcinosarcoma of the ovary in a patient with a germline BRCA2 mutation: evidence for monoclonal origin.BACKGROUND: Themajority of hereditary breast and ovarian cancers are associated with germline mutations in BRCA1 or BRCA2. While the occurrence of breast carcinoma and epithelial ovarian carcinoma in association with BRCA mutations is firmly established, the etiologic role of these genes in the development of other tumor types is less well documented. carcinosarcoma of the ovary is an uncommon tumor consisting of both malignant epithelial and malignant mesenchymal components. OBJECTIVE: Here we report a patient with an ovarian carcinosarcoma who was found to harbor a germline mutation in BRCA2. We sought to link the BRCA2 mutation to the pathogenesis of this tumor as well as to determine whether both histologic components arose from the same progenitor cell. methods: microdissection and molecular genetic analyses of the carcinomatous and sarcomatous components of this tumor were performed. RESULTS: Clonal loss of the wild-type BRCA2 allele as well as the same somatic mutation of the TP53 gene was evident in both histologic components. CONCLUSIONS: These data indicate that hereditary ovarian carcinosarcoma may result from a mutation in BRCA2 and that both histologic elements of this tumor arose from the same progenitor cell.- - - - - - - - - - ranking = 0.8keywords = sarcoma (Clic here for more details about this article) |
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