1/3. Long-standing pain relief of adiposis dolorosa (Dercum's disease) after intravenous infusion of lidocaine.A 60-year-old woman with adiposis dolorosa for 20 years was treated with repeated intravenous infusions of lidocaine. Partial relief of pain in the legs was obtained after 1.3 gm. A dose of 5.2 gm lidocaine given for 4 days was needed for complete pain relief. The effect lasted for 3 weeks, and then the pain gradually returned. The patient has now been given two additional treatments with complete pain relief for 2 months. The mechanism of the effect remains unknown.- - - - - - - - - - ranking = 1keywords = adiposis dolorosa, adiposis, dolorosa (Clic here for more details about this article) |
2/3. Intravenous lidocaine for the treatment of intractable pain of adiposis dolorosa.adiposis dolorosa (Dercum's disease) is a syndrome of painful adipose tissue which occurs most often in post-menopausal women and is associated with obesity, asthenia, and emotional disturbances. The etiology is uncertain, but is probably multifactorial. Numerous treatments to relieve the pain have generally been unsuccessful. A patient with adiposis dolorosa was treated with intravenous infusions of lidocaine over a two-year period. Relief from pain lasted from two to 12 months after each infusion. A single-blind placebo infusion did not relieve the pain. lidocaine infusions did not relieve the pain of diabetic neuropathy or of angina in this patient. The mechanism of relief of pain of adiposis dolorosa by lidocaine is uncertain, but previously reported central effects of lidocaine suggest that alterations in the central nervous system may be responsible.- - - - - - - - - - ranking = 1.2104700831417keywords = adiposis dolorosa, adiposis, dolorosa (Clic here for more details about this article) |
3/3. Management of intractable pain in adiposis dolorosa with intravenous administration of lidocaine.Intractable pain in a patient with adiposis dolorosa (Dercum's disease) was treated by IV administration of lidocaine (200 to 400 mg). Relief was maximum 20 minutes after the end of drug infusion and persisted for over 10 hours. Toxicity was minimal. Slow EEG waves which appeared during drug administration disappeared within 20 minutes.- - - - - - - - - - ranking = 1keywords = adiposis dolorosa, adiposis, dolorosa (Clic here for more details about this article) |