1/4. Punctate porokeratotic keratoderma: some pathogenetic analyses of hyperproliferation and parakeratosis.An 82-year-old Japanese woman had numerous palmoplantar keratotic plugs and pits, resembling 'music box spines'. Histological examination revealed compact columns of parakeratosis in the horny layer. Ultrastructually, the affected stratum corneum contained numberous variable-sized pyknotic nuclei, and cells in the stratum granulosum contained fewer keratohyalin granules. Autoradiographic analysis by [3H]thymidine [3H]TdR incorporation into epidermal cells of affected skin slices in organ culture revealed that only basal cells below the keratotic plug were stimulated to proliferate. Two-dimensional gel electrophoresis revealed that palmar keratotic plugs contained the keratin filaments that are specifically present in the plantar viable epidermal layer, or other hyperproliferative epithelial cells.- - - - - - - - - - ranking = 1keywords = palm (Clic here for more details about this article) |
2/4. Porokeratotic eccrine ostial and dermal duct nevus.A 6-year-old girl with congenital porokeratotic eccrine ostial and dermal duct nevus involving the palmoplantar surfaces (ie, the back of the hands and feet), the limbs, the neck, and the axillae is described. The clinical and histopathologic findings are presented. This entity should be taken into consideration in the differential diagnosis of linear keratotic cutaneous eruptions.- - - - - - - - - - ranking = 0.5keywords = palm (Clic here for more details about this article) |
3/4. lichen nitidus of the palms.A case is presented of lichen nitidus that evolved into an acquired palmar keratoderma in a fifty year old woman; this is a rare manifestation of the disease. lichen nitidus must be considered in the differential diagnosis of keratoderma palmaris.- - - - - - - - - - ranking = 3keywords = palm (Clic here for more details about this article) |
4/4. Spiny keratoderma: a common under-reported dermatosis.Spiny keratoderma is a dermatosis consisting of multiple projections located on the palms and soles, with a distinct histology characteristic of a parakeratotic column above a hypogranular epidermis. We report six cases discovered within a year and review the present literature on spiny keratoderma. The average age of the patients was 57 years. Fifty-seven percent of the patients were male and forty-three percent were female. The duration of lesions ranged from 4 months to 40 years. Symptoms were variable, however, lesions were often unnoticed by the patient. The location of the lesions involved the palms and soles or the palms alone. Past medical history was significant for hypertension and hyperlipidemia treated with HMG-CoA reductase inhibitors. Lesions often occurred in patients involved in manual labor. Spiny keratoderma is a relatively common under-reported dermatosis found most often in older patients with history of manual labor and is possibly related to treatment with HMG-CoA reductase inhibitors.- - - - - - - - - - ranking = 1.5keywords = palm (Clic here for more details about this article) |