1/17. Cancer-associated retinopathy in a patient with advanced epithelial ovarian carcinoma.BACKGROUND: Paraneoplastic phenomena, such as retinopathy, may herald an unsuspected gynecologic malignancy. CASE: A 75-year-old woman presented to a neuro-ophthalmologist with abrupt onset of unilateral visual loss. A diagnosis of branch retinal artery occlusion was made and she was treated with aspirin. An echocardiogram subsequently revealed atrial dilation and she was placed on coumadin therapy. Her vision worsened and a cancer-associated retinopathy was entertained. A serum cancer-associated retinopathy antibody was detected; subsequent computed tomographies of the abdomen and pelvis revealed findings consistent with a primary ovarian carcinoma. CONCLUSION: patients with unexplained ophthalmologic symptoms may harbor an underlying gynecologic cancer.- - - - - - - - - - ranking = 1keywords = gynecologic (Clic here for more details about this article) |
2/17. dermatomyositis as a presenting symptom of ovarian cancer.BACKGROUND: Among gynecologic malignancies, the coexistence of ovarian cancer and dermatomyositis is most frequent. CASE: A 75-year-old woman presented with dermatomyositis, and a search for underlying malignancy found an otherwise asymptomatic ovarian carcinoma with para-aortic lymph node metastases. After resection and chemotherapy, the muscle weakness and skin lesions relating to dermatomyositis began to improve. CONCLUSION: dermatomyositis can be the only presenting symptom of ovarian cancer, so an evaluation for suspected underlying malignancy should be done.- - - - - - - - - - ranking = 0.5keywords = gynecologic (Clic here for more details about this article) |
3/17. Bilateral diffuse uveal melanocytic proliferation associated with extraocular cancers: review of a process particularly associated with gynecologic cancers.We reviewed cases of a paraneoplastic syndrome in which uveal melanocytes proliferated and led to blindness. Eighteen cases were derived from the literature, and two were taken from our institution. The average patient age at the time of the diagnosis was 63 years (range, 34-89 years). There were 13 women and 7 men. In approximately half of the cases, the ocular symptoms antedated those of the inciting tumor. Most of the inciting tumors were poorly differentiated carcinomas. The most common tumors were from the female genital tract (ovary and uterus) among the women patients and from the lung among the men. Tumors from the breast were rare (one possible case), and tumors of the prostate were conspicuously absent. All five inciting tumors whose histopathology was reviewed expressed neuron-specific enolase, but none prominently expressed antigens more specific for neuroendocrine carcinomas such as chromogranin or synaptophysin. It is our experience that many general pathologists are not aware of this unique paraneoplastic syndrome. Our report is the first to document a statistically significant association between this syndrome and gynecologic cancers.- - - - - - - - - - ranking = 2.5keywords = gynecologic (Clic here for more details about this article) |
4/17. Ovarian carcinoma causing cerebellar degeneration.Subacute cerebellar degeneration can be associated with malignancies. If the underlying tumor is a gynecological one, Purkinje cell cytoplasmic antibodies in serum serve as tumor markers.- - - - - - - - - - ranking = 0.5keywords = gynecologic (Clic here for more details about this article) |
5/17. paraneoplastic cerebellar degeneration: successful early detection and treatment of cancer through characterization of the anti-Purkinje cell antibody.paraneoplastic cerebellar degeneration (PCD) is thought to be caused by an autoantibody against both tumor and neuronal tissue. Such autoantibodies are most frequently detected in patients with gynecological or breast cancer, and are designated as anti-Yo. We report here a patient with PCD whose underlying cancer could not be detected despite extensive tumor survey. IgG in her serum and cerebrospinal fluid reacted with the cytoplasm of cerebellar purkinje cells immunohistochemically. On immunoelectron microscopy, the endoplasmic reticulum and Golgi complex were stained. Her IgG bound to the 58 kD band on immunoblots of cerebellar proteins. A reaction was also observed with the recombinant proteins deduced from the complementary dna clone encoding a neuronal cell antigen reported by Sakai et al (Ann Neurol 28: 692, 1990). Based on these results, successful early resection of fallopian tube adenocarcinoma was performed. It is crucially important to characterize these PCD related autoantibodies for the early treatment of underlying malignant tumors.- - - - - - - - - - ranking = 0.5keywords = gynecologic (Clic here for more details about this article) |
6/17. Small cell carcinoma of the endometrium with associated ocular paraneoplastic syndrome.Small cell carcinomas are well-recognized tumors known to occur predominantly in the lung. These neoplasms occasionally are associated with a variety of symptoms caused by hormones and other products produced by the tumor cells (paraneoplastic syndromes). However, in the gynecologic tract such neoplasms are extremely rare. The authors report the case of an elderly woman who presented with visual disturbances caused by a primary small cell carcinoma of the uterus.- - - - - - - - - - ranking = 0.5keywords = gynecologic (Clic here for more details about this article) |
7/17. Palmar fasciitis and arthritis syndrome associated with metastatic ovarian carcinoma: a report of four cases.Palmar fasciitis and polyarthritis syndrome (PFPAS) is an uncommon paraneoplastic syndrome associated with several malignant neoplasms. We identified 4 patients with PFPAS and ovarian carcinoma. Palmar fasciitis, at times severe, and inflammatory polyarthritis dominated the clinical presentation in all 4 patients. In 3 of our 4 patients the presentation of palmar fasciitis and inflammatory polyarthritis preceded the diagnosis of ovarian carcinoma. Magnetic resonance scanning and biopsy examination of palmar nodules in one patient revealed findings of inflammation and fibrosis. A literature review found 10 other cases of PFPAS associated with ovarian carcinoma. Improvement in palmar fasciitis and inflammatory arthritis often occurs after successful treatment of the ovarian carcinoma. Digital contractures, however, can persist. We recommend a gynecologic examination in any woman presenting with the sudden onset of unexplained hand pain, palmar inflammatory fasciitis, palmar fibromatosis, and digital contractures.- - - - - - - - - - ranking = 0.5keywords = gynecologic (Clic here for more details about this article) |
8/17. Small cell carcinoma of the uterine corpus manifesting with visual dysfunction.BACKGROUND: Small cell carcinoma in the uterine corpus rather than the endometrium has not been reported yet which resembles a uterine leiomyosarcoma on an imaging study. Furthermore, gynecologic malignancies manifested as a visual dysfunction render the early suspicion and accurate diagnosis a difficult proposition. CASE: A 57-year-old Korean woman was referred to the Department of obstetrics and gynecology due to incidentally detected uterine mass. She had been suffering from a visual loss for several weeks. This uterine mass mimicking a leiomyosarcoma on pelvis MRI was identified to be a small cell carcinoma via a transvaginal gun biopsy and consequent immunostaining. The patient was then scheduled to undergo a regimen of chemotherapy with etoposide and carboplatin. CONCLUSION: Small cell carcinoma may arise from the uterine corpus rather than the endometrium and may also be accompanied by visual symptoms.- - - - - - - - - - ranking = 0.5keywords = gynecologic (Clic here for more details about this article) |
9/17. guillain-barre syndrome occurring after adjuvant chemo-radiotherapy for endometrial cancer.BACKGROUND: The association between guillain-barre syndrome (GBS) and malignancy is uncommon and has not been previously reported in gynecological cancers. CASE: Our case documents this syndrome occurring in a patient shortly after completion of adjuvant chemo-radiotherapy for endometrial carcinoma. We review the current literature and discuss potential pathogenic mechanisms of this likely paraneoplastic association. CONCLUSION: GBS in cancer patients is a potentially life-threatening condition and should be differentiated from simple chemotherapy toxicity, particularly as effective treatment is available.- - - - - - - - - - ranking = 0.5keywords = gynecologic (Clic here for more details about this article) |
10/17. Recurrent ovarian carcinoma: presentation as idiopathic thrombocytopenic purpura and a splenic mass.We report a case of a 38 year old female who was treated for a Stage IIIb serous cystadenocarcinoma of the ovary with cytoreduction, combination chemotherapy, negative second look laparotomy, and adjuvant chemotherapy, who eight months later presented with Idiopathic Thrombocytopenic purpura (ITP) and an isolated splenic recurrence. review of the literature shows only four other cases of gynecologic malignancy which exhibited this pattern of recurrence. This case is the first where the primary lesion was an ovarian carcinoma and the patient presented with thrombocytopenia.- - - - - - - - - - ranking = 0.5keywords = gynecologic (Clic here for more details about this article) |
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