1/22. Anaemia in lung transplant patient caused by parvovirus B19.The case history is presented of a lung transplant patient who developed prolonged parvovirus B19 infection with severe transfusion dependent anaemia. The patient was treated with intravenous immunoglobulin after which the haemoglobin rose, together with a reticulocytosis. The patient then remained transfusion free and the virus cleared more than three months after the initial immunoglobulin treatment. The clinical and social implications for this group of patients are discussed.- - - - - - - - - - ranking = 1keywords = anaemia (Clic here for more details about this article) |
2/22. Increase in B19 viral load prior to relapse of anaemia in an AIDS patient with persistent B19 infection.Anaemia caused by persistent parvovirus B19 infection can be remitted by intravenous immunoglobulin (IVIG) treatment. However, maintenance IVIG therapy is required in some AIDS patients as well as patients with combined immuno-deficiency because of relapse of anaemia. We used a simple semi-quantitative polymerase chain reaction (PCR) method to trace plasma B19 viral load after administration of IVIG. We noted that the rebound of B19 viral load occurred 6 weeks prior to detection of anaemia. This method may be helpful in determining the interval of maintenance IVIG therapy.- - - - - - - - - - ranking = 6keywords = anaemia (Clic here for more details about this article) |
3/22. life-threatening human parvovirus B19 infection transmitted by intravenous immune globulin.Infection of human parvovirus B19 (B19) is usually a self-limiting febrile illness, but can sometimes be life-threatening under certain circumstances, such as aplastic crisis in patients with haemolytic anaemia, hydrops fetalis in pregnant women and fulminant hepatitis. B19 can be transmitted through respiratory secretions, transplacentally and by transfusion of blood or blood products. In the present case, administration of intravenous immune globulin (i.v.Ig) transmitted B19 infection and consequently caused pure red cell aplasia and aggravation of hepatitis to fulminant hepatitis. Our case may raise important questions as to the safety of i.v.Ig and possible contamination by B19.- - - - - - - - - - ranking = 1keywords = anaemia (Clic here for more details about this article) |
4/22. Pure red cell aplasia due to parvovirus following treatment with CHOP and rituximab for B-cell lymphoma.A 26-year-old woman, diagnosed with diffuse large B-cell lymphoma, was treated with CHOP (cyclophosphamide, hydroxydaunomycin, oncovin, prednisone), rituximab and radiotherapy. She developed transfusion-dependant anaemia, which persisted following chemotherapy. bone marrow aspirate and biopsy were consistent with pure red cell aplasia and parvovirus infection. serology was negative for previous or acute infection but parvovirus dna was detected by polymerase chain reaction. Administration of intravenous immunoglobulin (1 g/kg) resulted in reticulocytosis and recovery of her haemoglobin. We hypothesize that rituximab caused depletion of her normal B cells, resulting in an inability to mount a primary immune response to parvovirus infection.- - - - - - - - - - ranking = 1keywords = anaemia (Clic here for more details about this article) |
5/22. Aplastic crisis and leg ulceration: two rare complications of hereditary sideroblastic anaemia.Aplastic crisis as a result of parvovirus infection is seen in a number of haematologic disorders characterized by decreased red cell survival, and leg ulceration due to unknown causes is seen in a number of haemolytic anaemias. Neither of the two has been reported in a case of sideroblastic anemia. We report one case with each of these complications in association with sideroblastic anaemia.- - - - - - - - - - ranking = 6keywords = anaemia (Clic here for more details about this article) |
6/22. parvovirus B19-related anaemia after renal transplantation.We describe here the case of a renal transplant recipient treated by sirolimus based immunosuppresive therapy, who developed severe and unusual pancytopenia 2 months after renal transplantation. parvovirus B19 primo-infection was diagnosed. The first course of intravenous immunoglobulin failed. bone marrow aspiration confirmed megaloblastic anaemia associated with parvovirus B19. Finally, this infection was succesfully treated by the reduction of immunosuppression combined with a second course of intravenous immunoglobulin.- - - - - - - - - - ranking = 5keywords = anaemia (Clic here for more details about this article) |
7/22. hydrops fetalis and neonatal death from human parvovirus B19: an unusual complication.A case of prenatally diagnosed human parvovirus B19 (HPVB19) infection is reported. The neonate died after intrauterine therapy and premature delivery.The fetus was diagnosed with oedema, cardiomegaly, poor myocardial contractility and a pericardial effusion at 24/40 weeks' gestation. Ultrasound using colour flow Doppler showed a midcerebral artery peak systolic velocity (MCA PSV) raised at 45 cm/s, suggesting fetal anaemia. This was confirmed on fetal blood sampling, but recovery was suggested with a reticulocyte count of 16.8%. The fetal karyotype was normal, 46,XY. Fetal IgM was positive for parvovirus. A week later, severe fetal anaemia was suspected and intrauterine transfusion carried out. Altogether three transfusions were given. At 31/40 weeks, the mother presented to her local hospital with suspected preterm labour, a caesarean section was carried out because of fetal compromise on cardiotocography. The baby was in poor condition at birth and resuscitation was stopped at 45 min of age. The post-mortem examination confirmed the hydrops and proved persistent parvovirus infection, cardiac involvement and severe liver fibrosis.HPVB19 generally follows a benign course with intrauterine therapy; however, in this case, the fetus died despite successful transfusions. The reasons for this are discussed.- - - - - - - - - - ranking = 2keywords = anaemia (Clic here for more details about this article) |
8/22. Effusive-constrictive pericarditis associated with human parvovirus B19 infection.A woman presented after an illness of fever and arthralgia, with increasing shortness of breath. Investigations revealed she had effusive constrictive pericarditis, anaemia, a pulmonary infiltrate, and evidence of acute parvovirus B19 infection. parvovirus should be considered as a cause of pericarditis, especially if there is recent arthralgia or associated anaemia.- - - - - - - - - - ranking = 2keywords = anaemia (Clic here for more details about this article) |
9/22. parvovirus infection and anaemia in a patient with AIDS: case report.opportunistic infections such as pneumocystis carinii pneumonia are well-recognised in patients with the acquired immune deficiency syndrome (AIDS). Anaemia due to a variety of causes also occurs in AIDS. Persistent infection with parvovirus (B19) causing severe anaemia has been reported in patients with leukaemia and congenital immunodeficiency. A case is now reported of parvovirus infection and anaemia, in an adult with AIDS, which responded dramatically to immunoglobulin therapy.- - - - - - - - - - ranking = 6keywords = anaemia (Clic here for more details about this article) |
10/22. B19 parvovirus infection causing aplastic crisis in 3 out of 5 family members with hereditary spherocytosis.B19 parvovirus infection is a principal cause of transient bone marrow suppression in patients with chronic haemolytic anaemias. Acute infection is described in a family of five individuals with hereditary spherocytosis; three of them developed marked hypoplastic anaemia.- - - - - - - - - - ranking = 2keywords = anaemia (Clic here for more details about this article) |
| | Next -> |