1/12. Epithelioid blue naevus of the genital mucosa: report of four cases.Epithelioid blue naevi are an unusual cytological variant of blue naevus that have been recently described mostly in patients with the carney complex, although they may also occur in isolation. This variant of blue naevus is composed of melanin-laden polygonal epithelioid melanocytes situated within the dermis. The neoplastic cells show no maturation with progressive depth of dermal infiltration and, in contrast with the usual stromal changes in blue naevi, epithelioid blue naevi exhibit no dermal fibrosis. We describe four cases of epithelioid blue naevus located on the genital mucosa in four patients with no evidence of the carney complex. Three male patients showed an epithelioid blue naevus on the mucosa of the glans penis and a female patient had a lesion of the right labium minoris. Histopathologically, the lesions consisted of entirely intradermal melanocytic naevi composed mostly of heavily pigmented epithelioid melanocytes involving the dermis of the genital mucosa. Immunohistochemically, in all cases, epithelioid melanocytes expressed immunoreactivity for S-100 protein, HMB-45, Melan-A and MiTF antibodies.- - - - - - - - - - ranking = 1keywords = dermis (Clic here for more details about this article) |
2/12. Penile reconstruction for extramammary Paget's disease.The authors report their experience of an extremely rare case of extramammary Paget's disease presenting a deformational change of the penis, which required penile reconstruction after tumor resection. Tumor cells had invaded the dermis beyond the basement membrane of the epidermis. Tumor cells were found at the epithelium of the urethra, but had not invaded the corpus cavernosum. However, fibrotic changes were found in the corpus cavernosum. More than half the length of the penis was resected. Penile reconstruction was performed using a free sensory radial forearm flap. The defects in the mons pubis, scrotum, and the remaining corpus cavernosum were covered using a meshed split skin graft or sheeted split skin graft. Ten months after the operation, the tumor had not recurred and no metastasis was found. The urinary stream was narrow compared with that of a healthy man, but urinary voiding had not been disturbed. Sensory recovery was 12 mm with the two-point discrimination test at the distal end of the reconstructed penis.- - - - - - - - - - ranking = 1keywords = dermis (Clic here for more details about this article) |
3/12. granular cell tumor of the penis: clinicopathologic evaluation of 9 cases.The occurrence of granular cell tumor (GCT) in penile tissue is very rare, with only 9 examples reported to date in the English-language literature. Herein, we describe the clinicopathologic and immunohistochemical findings in 9 additional cases. The patients ranged in age from 20 to 60 years (mean, 42 years; median, 40 years) at time of diagnosis. All penile tumors were solitary and arose in the dermis of the penile shaft (n=4), prepuce (n=3), and corona (n=2). A patient had a history of multiple cutaneous GCTs. Duration of symptoms before surgery ranged from 5 days to 2 years with the presence of an asymptomatic nodule representing the most common tumor-related complaint (n=8). The lesions ranged in size from 0.6 to 2.5 cm (mean, 1.5 cm; median, 1.5 cm). Microscopically, the tumors were moderate to highly cellular and were composed of oval to polygonal-shaped cells with abundant coarsely granular eosinophilic cytoplasm. Tumor cells grew in infiltrating nests, cords, and trabeculae and showed neural (n=2) and vessel wall (n=1) invasion or formed a relatively well-marginated solid nodule. Bland cytological features with only rare cells showing nucleomegaly (n=7) or spindling (n=3) were exhibited by 8 tumors. A tumor demonstrated diffuse nuclear atypia and was classified as "atypical." Mitotic activity ranged from 0 to 8 mitoses (mean, 1.4 mitoses) per 50 high-powered fields with no atypical division figures identified. All tumors tested showed moderate to strong immunohistochemical expression of S100 protein (n=6) and low-affinity nerve growth factor receptor (n=5), which was useful for detecting small deposits of tumor and helpful in evaluating surgical margins. Focal tumor cell immunoreactivity was observed for calretinin (4/6 cases) and glial fibrillary acidic protein (1/6 cases). All patients underwent simple (local) excision of their tumor. Complete follow-up data (mean, 21 years; interval range, 0.5-28 years) were available for 6 patients. No patient experienced recurrence or metastatic spread of tumor although surgical margins were microscopically involved by tumor in 5 cases. Benign GCT involving superficial soft tissue of the penis can be adequately managed by a simple excision. patients with microscopically involved surgical margins can be clinically followed without immediate additional surgery.- - - - - - - - - - ranking = 0.5keywords = dermis (Clic here for more details about this article) |
4/12. An unusual case of extramammary Paget's disease. Paget's disease of the glans penis probably originating from a prostatic duct carcinoma (transitional cell carcinoma of the prostate).A patient, having been treated by total cystectomy and Bricker's conduit operation for prostatic duct carcinoma with intraepithelial extension into the prostatic urethra and bladder, developed an annular, psoriasiform eruption around the external orifice of the urethra two and one-half years later. A biopsy of this lesion showed pagetoid changes of the epidermis. Microscopic examination of the surgical specimen, consisting of the glans penis and corpus spongiosum, demonstrated intraepithelial-tumor permeation into the glans penis, penile urethra, and periurethral glands (Littre). It seems reasonable to conclude that this is an unusual case of Paget's disease of the glans penis which probably originated from a prostatic duct carcinoma.- - - - - - - - - - ranking = 0.5keywords = dermis (Clic here for more details about this article) |
5/12. Metastatic epidermotropic squamous carcinoma histologically simulating primary carcinoma.We present a case of a patient with penile squamous carcinoma and unilateral inguinal nodal involvement. Histological sections of the inguinal tumor demonstrated a basaloid (small-cell) squamous carcinoma of the type that arises from modified skin or mucosa. Multiple cutaneous lesions subsequently developed in the ipsilateral lower extremity. Biopsies revealed tumor that had the same histologic appearance as the nodal metastasis but that also showed a smooth and continuous connection with the overlying epidermis. We discuss the significance of this finding and review the pertinent literature.- - - - - - - - - - ranking = 0.5keywords = dermis (Clic here for more details about this article) |
6/12. A case of acquired lymphangioma due to a suspected old filariasis and a review of literature.A 65-year-old man presented in 1992 with multiple papular lesions on the scrotum and foreskin. His medical history revealed that, at the age of 25, he was diagnosed as having filariasis and treated conservatively at a hospital in hawaii. The histologic study of the scrotal skin showed large, dilated vascular spaces in the upper dermis lined with a single layer of endothelial cells that were negative for Factor 8-related antigen. The diagnosis was acquired lymphangioma due to a suspected old filariasis infestation, although serologic tests for filarial antibodies were negative. The paper also presents a review of the literature of acquired lymphangioma in japan with a brief discussion of etiology and nomenclature.- - - - - - - - - - ranking = 0.5keywords = dermis (Clic here for more details about this article) |
7/12. A case of verrucous carcinoma associated with human papillomavirus type 16 dna.We report here a case of verrucous carcinoma which occurred on the penis of a 75-year-old male. The nodule was first noted six months earlier and was whitish, cauliflower-like, and 17 x 19 mm in size. The histopathological examination revealed hypertrophic epidermal proliferation with pale staining keratinocytes, extending into the deep dermis. Partial penectomy and inguinal lymph node dissection were done. No lymph node metastasis was recognized. dna was isolated from the frozen tumor tissue and examined for the presence of human papillomavirus (HPV) 16, 18, and 33 dna by the polymerase chain reaction (PCR), using common and specific primers. A 140 base pair (bp) band was amplified and finally determined to be the HPV16 sequence by dot-blot hybridization.- - - - - - - - - - ranking = 0.5keywords = dermis (Clic here for more details about this article) |
8/12. Mucinous syringometaplasia. A case report with review of the literature.We describe a case of mucinous syringometaplasia in a 53-year-old man. The lesion was located on a previously unreported site, the shaft of the penis. Histologically the lesion contained bland mucinous cells in acrosyringia that extended to the adjacent epidermis. A review of previously reported cases is provided. Even though the name given to this entity implies a reactive nonneoplastic condition, the possibility that this is a benign intraepithelial mucinous neoplasm has not been ruled out. The main differential diagnosis is with extramammary Paget's disease.- - - - - - - - - - ranking = 0.5keywords = dermis (Clic here for more details about this article) |
9/12. Solitary cutaneous myofibroma of the glans penis.In the present report, we describe a cutaneous myofibroma with a monophasic pattern. The patient was a 12-year-old white boy with an asymptomatic yellow nodule on his glans penis for about 2 1/2 months. The nodular pattern of growth is distinctive: nests of plump spindle cells with a tendency toward interstitial hyalinization within the dermis. Confirmation of the myofibroblastic nature of the proliferation was obtained by histochemical and immunohistochemical studies. The tumor cells showed immunoreactivities for vimentin, alpha-smooth-muscle actin, and collagen type iv but did not stain for desmin. To the best of our knowledge, this is the first case of cutaneous myofibroma to occur on the glans penis. This tumor should be included in the differential diagnosis of mesenchymal neoplasms of the penis.- - - - - - - - - - ranking = 0.5keywords = dermis (Clic here for more details about this article) |
10/12. Penile basal cell carcinoma with eccrine differentiation.Basal cell carcinoma (BCC) is rare on the penis. There have been only 17 cases of penile BCC reported in the literature. Eccrine differentiation may not be uncommon in BCC but has not been reported in penile BCC. We report here a 75-year-old man with multiple penile BCC with histological features of eccrine differentiation. A brief review of the literature is included. Basal cell carcinoma (BCC) is the most commonly diagnosed malignant skin tumour; it probably originates from pluripotential cells in the epidermis or hair follicle. More than 90% of BCCs are located on the head or neck, and its occurrence on the penis is rare. Seventeen cases of penile BCC have been reported in the literature.- - - - - - - - - - ranking = 0.5keywords = dermis (Clic here for more details about this article) |
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