1/31. Abnormal deposition of type VII collagen in Kindler syndrome.Kindler syndrome is an extremely rare genetic disorder with features of epidermolysis bullosa and poikiloderma congenitale. Approximately 70 cases have been documented in the past 50 years, but only a few investigations of the basement membrane components have been done on these patients. The aim of this study was to examine the components of the basement membrane zone in search of the pathobiological defect(s) responsible for the clinical findings from a female 16-year-old patient diagnosed with Kindler syndrome. This patient also suffered from advanced early-onset periodontal disease. Biopsies were taken from inflamed gingiva and noninflamed oral mucosa as part of periodontal treatment. The basement membrane zone was examined using immunofluorescence microscopy to bullous pemphigoid antigens 1 and 2, collagen types IV and VII, laminins-1 and -5, and integrins alpha3beta1 and alpha6beta4. The biopsies studied revealed blistering with trauma above the level of lamina densa based on distribution of type IV collagen and laminin-1 at the blister floor. In the noninflamed mucosa, discontinuous areas of the basement membrane zone were found. Expression of the basement membrane zone components and the integrins studied appeared otherwise normal with the exception of type VII collagen which was found in abnormal locations deep in the connective tissue stroma. Our results suggest that Kindler syndrome is associated with abnormalities in the construction of the basement membrane, especially in the expression of type VII collagen. These alterations are likely to play a role as etiological factors leading to blister formation and early onset periodontal disease.- - - - - - - - - - ranking = 1keywords = membrane (Clic here for more details about this article) |
2/31. Clinical results with exposed polyglactin 910 resorbable membranes for guided tissue regeneration.Three cases are presented where early exposure of a resorbable membrane occurred during guided tissue regeneration therapy. An antimicrobial regimen was selected to determine whether infection of exposed membranes could be controlled to the point of achieving acceptable clinical results without membrane removal. The results suggest that with the use of the antimicrobial regimen: (1) exposure is compatible with successful clinical results, and (2) removal is not necessary.- - - - - - - - - - ranking = 1.1666666666667keywords = membrane (Clic here for more details about this article) |
3/31. Cemental tear treated with guided tissue regeneration: a case report 3 years after initial treatment.Cemental tear is a rare but probably underdiagnosed condition that may be a factor in rapid periodontal breakdown. The present case report describes the regenerative treatment of a periodontal lesion around a mandibular canine in a 50-year-old woman. The preoperative radiograph revealed a small cemental tear within an intrabony lesion. The three-wall bony lesion was treated with a barrier membrane and followed for 3 years. periodontal pocket reduction was 5.5 mm, and attachment gain amounted to 3.5 to 4.5 mm Standardized radiographs showed remarkable, 1.6-mm bone fill of the intrabony lesion. Also, a band of keratinized tissue had formed.- - - - - - - - - - ranking = 0.16666666666667keywords = membrane (Clic here for more details about this article) |
4/31. Treatment of peri-implantitis: longitudinal clinical and microbiological findings--a case report.Failing implants can be successfully treated by surgical procedures that use either bone fillers or membranes combined with an antimicrobial treatment. In this report, we present a case of failing implants with the corresponding treatment and results of 8 years of follow-up.- - - - - - - - - - ranking = 0.16666666666667keywords = membrane (Clic here for more details about this article) |
5/31. Osseous autografts. II. Histological responses to osseous coagulum-bone blend grafts.Three human intraosseous lesions were treated using osseous coagulum-bone blend as graft material. These sites were surgically removed 6 to 13 weeks after treatment and the blocks prepared for histologic analysis. Periodontal remodeling at the site of grafting was noted in all specimens. This remodeling involved the osseous walls, periodontal ligament, cementum and graft spicules. Both osteoclastic and osteoblastic activities were seen at the borders of the spicules. Exfoliation of spicules was particularly frequent in the six-week specimen. Nevertheless, regenerating of both bone and cementum was actively taking place even in this early specimen and was still evident in the older specimens. Of particular interest was the apparent marked increase in cementogenesis at the graft sites and the variations in parallel or functional orientation of the periodontal ligament in these areas. Significant functional orientation of segments of the periodontal ligament were seenin the early specimens, but not in the latter one. The reason for such variations in ligament pattern is not known at this time.- - - - - - - - - - ranking = 500.49986961552keywords = periodontal ligament, ligament (Clic here for more details about this article) |
6/31. Combined treatment of periodontal disease and benign mucous membrane pemphigoid. Case report with 8 years maintenance.BACKGROUND: Desquamative gingivitis may be the clinical manifestation of one of several systemic diseases. The clinical course of the disease can be complicated by plaque-associated periodontitis. However, there is no information currently available for the concurrent management of both conditions. CASE REPORT AND RESULTS: This paper presents the treatment and 8-year maintenance of a patient with periodontal disease and benign mucous membrane pemphigoid (BMMP). The first phase of treatment included oral hygiene instructions and local corticosteroid administration, followed by scaling and root planing. The patient's compliance and excellent response to therapy allowed for subsequent surgical pocket elimination and augmentation of the zone of keratinized tissue for prosthetic reasons. Over the following 8 years, the patient's periodontal condition remained stable even though periodontal maintenance was erratic. For the control of BMMP, intermittent administration of corticosteroids was necessary, without any significant local or systemic side effects. CONCLUSIONS: We suggest that combined treatment and long-term maintenance of BMMP and periodontitis are feasible under certain conditions and propose a clinical protocol for treatment which could serve as a guideline for similar conditions.- - - - - - - - - - ranking = 0.83333333333333keywords = membrane (Clic here for more details about this article) |
7/31. Ridge preservation of dentition with severe periodontitis.Severe loss of alveolar bone height and width can occur following the removal of teeth with advanced periodontitis. This compromise of the alveolar bone can limit the options available for achieving an acceptable dental restoration. Two case reports are presented of alveolar ridge augmentation after tooth removal and before implant placement using bone grafting and a biodegradable membrane. The resultant alveolar ridges in both patients were adequate for the placement of dental implants.- - - - - - - - - - ranking = 0.16666666666667keywords = membrane (Clic here for more details about this article) |
8/31. Immunopathological diagnosis of cicatricial pemphigoid with desquamative gingivitis. A case report.Cicatricial pemphigoid (CP) is a chronic subepidermal bullous dermatosis which primarily involves the mucous membranes. The oral cavity and the eye are most frequently involved. Since extension of the lesion into the pharynx and esophagus causes sore throat and dysphagia and progressive ocular lesions may cause blindness, early and valid diagnosis is very important. Here we present a case of cicatricial pemphigoid with onset at age 45 in a patient who manifested severe periodontal disease and showed the lesion on the mucous membranes of the mouth (desquamative gingivitis), skin, and eyes. Since definite diagnosis is very important, we describe how we made a differential diagnosis from other diseases which also accompany desquamative gingivitis. We examined the clinical manifestations, blood test results, HLA-genotype, histopathologic findings of the affected tissue, and immunological findings in relation to autoimmunity. Since many of the CP cases are first referred to periodontists or dentists, we believe that the diagnostic strategy described in the present study will be quite informative for making rapid and definite diagnoses of similar cases.- - - - - - - - - - ranking = 0.33333333333333keywords = membrane (Clic here for more details about this article) |
9/31. Treatment of peri-implant defects with the vertical ridge augmentation procedure: a patient report.Most clinical patient reports apply the biologic principles of guided bone regeneration, in addition to defect filling with autogenous bone grafts or bone graft substitutes, in peri-implantitis therapy. Not infrequently, sites with membrane coverage have revealed early exposure, with subsequent infections, premature membrane removal, and insufficient bone regeneration. The present patient report demonstrates another surgical approach that uses the clinical principles and soft tissue management of vertical ridge augmentation, strictly following the same surgical protocol, on previously cleaned implant surfaces. The successful outcome of this surgical approach in one patient supports the feasibility of the selected treatment method in maintaining both the implants and the prosthetic reconstruction involved with peri-implantitis.- - - - - - - - - - ranking = 0.33333333333333keywords = membrane (Clic here for more details about this article) |
10/31. Periodontal lesions in lipoid proteinosis.Lipoid proteinosis is a rare autosomal recessive heritable disease. Clinical features are hoarseness starting in infancy and the formation of yellowish papules and plaques on the skin and mucous membranes of the nose, oral cavity, pharynx and larynx. light and electron microscopy demonstrates a subepithelial accumulation of PAS-positive (hyaline) material around blood vessels and in the dermis. This case is unusual in that the gingiva is also involved in the lipoid proteinosis.- - - - - - - - - - ranking = 0.16666666666667keywords = membrane (Clic here for more details about this article) |
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