1/5. Morphologic-cytogenetic analysis of dedifferentiated liposarcomas with an extensive misleading leiomyosarcomatous component.This report describes two cases of recurrent retroperitoneal dedifferentiated liposarcoma characterized by an extensive leiomyomatous component that prevented the correct diagnosis before the last recurrence. Strong immunoreactivity with smooth muscle and desmin antibodies and ultrastructural features consistent with leiomyosarcoma were observed in the spindle-cell and/or myxoid-like components in all four recurrences in case 1, and in the spindle-cell component of the primary tumor and the first recurrence in case 2. In case 1, the correct diagnosis was suggested by the cytogenetic evidence of ring markers, a hallmark of well-differentiated/dedifferentiated liposarcoma. In case 2, tumor type was yielded mainly by the morphology of the second recurrence, which consisted entirely of a well-differentiated liposarcoma, a sclerosing inflammatory variant, as confirmed by the karyotype. Reevaluation of the first two surgical specimens of each case revealed small areas consistent with well-differentiated liposarcoma that had been previously overlooked. Despite the smooth-muscle antigen profile, both cases retained an mdm2 /p53 /cdk4 immunophenotype consistent with the genotype.- - - - - - - - - - ranking = 1keywords = karyotype (Clic here for more details about this article) |
2/5. monosomy 14, monosomy 22 and 13q--three chromosomal abnormalities observed in cells of two malignant mesotheliomas studied by banding techniques.Two malignant mesotheliomas were studied by banding techniques. Both neoplasms had a hypodiploid stemline. Five and eight marker chromosomes, respectively, were included in the stemline karyotypes. monosomy 14, monosomy 22 and a No. 13 with an interstitial long-arm deletion were deviations found in both neoplasms. In addition, closely located regions in No. 1 and No. 3 were involved in both tumors in the formation of other marker types with dissimilar morphology.- - - - - - - - - - ranking = 1keywords = karyotype (Clic here for more details about this article) |
3/5. Cytogenetic changes in ovarian mucinous cystadenocarcinoma of low malignant potential with persistent pseudomyxoma peritonei.Minimal cytogenetic data are available for low malignant potential ovarian neoplasms, and none for those complicated by pseudomyxoma peritonei. Cytogenetic analysis was performed on tissue obtained from a patient undergoing repeat evacuation of mucin and mucin-producing implants in pseudomyxoma peritonei originating from an ovarian mucinous cystadenocarcinoma of low malignant potential. Specimens obtained from intraperitoneal implants during one of the cyto/mucin-reductive procedures revealed a mixture of normal female karyotype (46,XX) and an abnormal karyotype with a deletion involving the short arm of chromosome 1, and a balanced translocation involving chromosomes 2 and 6, [46,XXdel(1)(p21p31), t(2;6)(q35;p21)]. The vast majority of the cells from three subsequent cyto/mucin-reductive procedures displayed a normal female karyotype with few cells containing random abnormalities.- - - - - - - - - - ranking = 3keywords = karyotype (Clic here for more details about this article) |
4/5. Translocation (3;3)(p14;q29) as the primary chromosome abnormality in a peritoneal mesothelioma.mesothelioma is a relatively rare malignant neoplasm arising from the serosal lining of the pleural, peritoneal, and pericardial cavities. Mesotheliomas are known to be associated with asbestos exposure. The karyotypes of these tumors have mostly been so complex as to preclude the identification of primary chromosome abnormalities. We present the cytogenetic analysis of two macroscopically distinct abdominal tumors, both diagnosed as peritoneal mesothelioma, occurring in a woman with a history of heavy asbestos exposure. Both tumors contained the same three karyotypically abnormal but cytogenetically related clones, with a balanced t(3;3)(p14;q29) as the primary chromosomal change. The fact that several chromosome abnormalities were common to both tumors strongly indicates that they arose through intraperitoneal spreading of a single neoplastic process; that is, they were not pathogenetically independent lesions. Our findings, taken together with previously published cytogenetic data on peritoneal mesotheliomas, indicate that a proportion of these tumors may be characterized by simple, balanced chromosomal rearrangements. At least a subset of peritoneal mesotheliomas arises through the same pathogenetic mechanisms that are involved in the pleural forms of this disease.- - - - - - - - - - ranking = 1keywords = karyotype (Clic here for more details about this article) |
5/5. association of klinefelter syndrome and abdominal teratoma: a case report.Extragonadal germ cell tumors are rare. The association with klinefelter syndrome has become observed recently. A case of an 11-month-old infant with klinefelter syndrome and a retroperitoneal mature teratoma is presented. In the tumor and lymphocytes, a 47,XXY karyotype was found. The association of klinefelter syndrome with germ cell tumors and its possible explanations are discussed.- - - - - - - - - - ranking = 1keywords = karyotype (Clic here for more details about this article) |