1/334. Photoinduced dermal pigmentation in patients taking tricyclic antidepressants: histology, electron microscopy, and energy dispersive spectroscopy.Two patients had been taking long-term tricyclic antidepressant therapy. Each developed a blue to slate-gray hyperpigmentation in sun-exposed areas. On histologic examination there were refractile golden brown granules free in the dermis along collagen bundles. Similar pigment was present in macrophages and along the basement membrane zone. The granules stained for melanin, but not for iron, and were bleached by the permanganate method. Electron microscopy showed varying size and shaped electron-dense granules within lysosomes and free in the dermis, which, in unstained sections, showed a less dense peripheral halo. This peripheral halo was also evident on light microscopy. Energy dispersive spectroscopy showed these granules to be rich in copper and sulfur (elements present in tyrosinase and pheomelanin, respectively). We believe that this represents a drug-melanosome complex, which is most likely caused by chronic photoactivation.- - - - - - - - - - ranking = 1keywords = light (Clic here for more details about this article) |
2/334. Pseudoporphyria induced by nabumetone.Nabumetone is a nonsteroidal anti-inflammatory drug, which has only rarely been associated with photosensitivity. We report a case of bullous lesions arising over photoexposed areas in a patient treated with nabumetone.- - - - - - - - - - ranking = 1.7853399381437keywords = sensitivity (Clic here for more details about this article) |
3/334. Photoallergy induced by quinidine.An 82-year-old woman presented with a lichenified dermatitis over light-exposed areas. The eruption cleared upon withdrawal of quinidine and recurred on re-administration of the drug. Though quinidine has not been recognized as a photo-sensitizing agent, upon review of the literature we have uncovered other cases which meet the criteria and justify including this drug among those capable of causing such reactions.- - - - - - - - - - ranking = 1keywords = light (Clic here for more details about this article) |
4/334. Lupus erythematosus exacerbated by griseofulvin.Because griseofulvin is one of the safest systemic medications, its side effects are often forgotten. This paper serves as a reminder that griseofulvin can precipitate or exacerbate lupus erythematosus. Two patients are described: one had a photosensitivity reaction to griseofulvin which precipitated discoid LE skin lesions, without any previous evidence of LE. The other, who had known systemic LE, developed a systemic reaction, consisting of fever and malasise.- - - - - - - - - - ranking = 1.7853399381437keywords = sensitivity (Clic here for more details about this article) |
5/334. Photolocalized tinea facialis.The case of a 34-year-old white woman with tinea facialis that persisted for nine months prior to diagnosis is presented. The confluent plaquelike erythematous eruption of the face with eyelid lichenification that flared outdoors was thought to represent polymorphic light eruption and was refractory to antibiotics, corticosteroids (topical and systemic), and antimalarials. A KOH preparation was positive when the dermatosis spilled onto the mandibular region, and restaining of the initial skin biopsy revealed fungal hyphae. Complete resolution was accomplished with griseofulvin and MicTin. tinea cab be added to the list of infectious agents that have a photosensitivity component. The fungus possibly "photolocalizes" to sun-damaged areas, ie, areas of increased capillary permeability. This case illustrates the importance of including tinea in considering diagnoses of sun-exposed lesions of the face.- - - - - - - - - - ranking = 2.7853399381437keywords = sensitivity, light (Clic here for more details about this article) |
6/334. Jessner's lymphocytic infiltrate and probable discoid lupus erythematosus occurring separately in two sisters.We describe two sisters with clinical and histological features suggestive of Jessner's lymphocytic infiltrate in one and discoid lupus erythematosus in the other. The occurrence of these two entities in one family now gives credence to the theory that Jessner's lymphocytic infiltrate is in the same disease spectrum as lupus and probably also polymorphic light eruption.- - - - - - - - - - ranking = 1keywords = light (Clic here for more details about this article) |
7/334. The investigation of quindoxin photosensitivity.Quindoxin (quinoxaline di-N-oxide) is a photosensitizer capable of producing photocontact dermatitis. The study of a group of seven affected subjects has provided evidence of persistent light reaction and "photoallergy", most probably to the parent substance and not to any photoproduct or contaminant. Clinical and photobiological similarities to the photosensitivity dermatitis and actinic reticuloid syndrome were demonstrated.- - - - - - - - - - ranking = 9.9266996907185keywords = sensitivity, light (Clic here for more details about this article) |
8/334. Photosensitivity due to alprazolam with positive oral photochallenge test after 17 days administration.We describe a 65-year-old male patient with photosensitivity due to alprazolam. A photopatch test was negative. An oral photochallenge test after taking alprazolam for 17 days with UVA irradiation was positive. alprazolam, a lipid-soluble drug, may require long duration of administration to cause photosensitivity.- - - - - - - - - - ranking = 10.712039628862keywords = sensitivity (Clic here for more details about this article) |
9/334. Polymorphic light eruption occurring solely on an area of naevoid telangiectasia.We report the case of a 60-year-old woman presenting with polymorphic light eruption occurring solely on an area of acquired naevoid telangiectasia. We have hypothesized that increased blood flow in the telangiectatic skin may reduce the threshold for expression of photosensitivity by permitting enhanced inflammatory cell trafficking to the overlying tissue.- - - - - - - - - - ranking = 6.7853399381437keywords = sensitivity, light (Clic here for more details about this article) |
10/334. Treatment of refractory solar urticaria with plasma exchange.BACKGROUND: Solar urticaria is a photodermatosis that can be very disabling for patients who are highly sensitive to light and can also be very resistant to therapy. OBJECTIVE: To correlate the results of serial phototesting in a patient with severe and refractory solar urticaria before and after treatment with plasma exchange. methods: plasma exchange was performed five times over a period of 10 days. Phototesting to ultraviolet A (UVA) irradiation and visible light was performed with fluorescent ultraviolet tubes and an incandescent lamp. RESULTS: The urticaria that developed after very low light doses during baseline phototesting could not be provoked following plasma exchange. The patient is now almost symptom-free, with only occasional and transient hives more than 21 months after her last plasma exchange. CONCLUSIONS: plasma exchange is a therapeutic modality to consider in highly light-sensitive patients when other treatments have failed.- - - - - - - - - - ranking = 4keywords = light (Clic here for more details about this article) |
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