1/6. Fatal pneumonia caused by burkholderia cepacia 9 months after resection of aspergilloma.A 69-year-old man developed an episode of severe community-acquired pneumonia 9 months after resection of aspergilloma. Although aspergillus fumigatus was also isolated in the pleural cavity, it did not invade the remaining lung parenchyma. The patient developed progressive bilateral pneumonia leading to death from respiratory failure. burkholderia cepacia was considered as prime pathogen, as it was repeatedly cultured from sputum and tracheal secretions, as well as the autopsy lung. B. cepacia is resistant to most antibiotics, and seldom causes pneumonia in patients without cystic fibrosis or chronic granulomatous disease. The precise reason that this apparently immunocompetent patient developed B. cepacia pneumonia remains unknown.- - - - - - - - - - ranking = 1keywords = granulomatous disease (Clic here for more details about this article) |
2/6. Newly diagnosed chronic granulomatous disease in a 53-year-old woman with crohn disease.BACKGROUND: Chronic granulomatous disease (CGD) is characterized by defective bactericidal activity of white blood cells, specifically, a defect in superoxide production. patients experience infections, predominantly caused by catalase-positive bacteria and fungal organisms, that may be severe and life-threatening. Most cases of CGD are diagnosed in children; however, it may rarely go undiagnosed until adulthood in individuals with unexplained infections and granulomatous inflammation. OBJECTIVE: To describe an adult with crohn disease and recurrent infections who was newly diagnosed as having CGD. methods: A 53-year-old woman with a history of liver abscesses and crohn disease presented with burkholderia cepacia pneumonia and required a right middle lobe resection. nitroblue tetrazolium test results confirmed the diagnosis of CGD, and Western blot analysis revealed the absence of the 47-phagocyte oxidase protein. Levels of Crohn-associated specific antibodies to saccharomyces cerevisiae and escherichia coli outer membrane porin C were elevated. RESULTS: The patient, newly diagnosed as having CGD, was given intravenous trimethoprim-sulfamethoxazole, after which she improved clinically and was discharged from the hospital in stable condition to receive daily oral trimethoprim-sulfamethoxazole treatment. CONCLUSIONS: The concomitant occurrence of crohn disease and CGD, both characterized by granulomatous inflammation, is noteworthy. This case study demonstrates that CGD should be considered in adults with recurrent infections, especially those caused by catalase-positive organisms, such as B cepacia.- - - - - - - - - - ranking = 5keywords = granulomatous disease (Clic here for more details about this article) |
3/6. Postmortem diagnosis of chronic granulomatous disease: how worthwhile is it?A previously healthy 11 year old boy died unexpectedly after a rapid course of progressive pneumonia. Postmortem microbiology and histopathology suggested an underlying diagnosis of chronic granulomatous disease. This was confirmed by neutrophil oxidative burst and gene mutation analysis of other family members, one of whom benefited from early bone marrow transplantation.- - - - - - - - - - ranking = 5keywords = granulomatous disease (Clic here for more details about this article) |
4/6. Treatment of intractable gastrointestinal manifestations of chronic granulomatous disease with cyclosporine.Gastrointestinal manifestations of chronic granulomatous disease of childhood include granulomatous inflammatory bowel disease. Severe colitis and perirectal disease developed in a 12-year-old boy with chronic granulomatous disease while he was receiving interferon gamma therapy. The boy had a deficiency of the 22 kd light chain of the cytochrome b heterodimer. After conventional medical therapy proved to be ineffective, a rapid clinical response was obtained to cyclosporine.- - - - - - - - - - ranking = 6keywords = granulomatous disease (Clic here for more details about this article) |
5/6. Severe Burkholderia (pseudomonas) gladioli infection in chronic granulomatous disease: report of two successfully treated cases.Chronic granulomatous disease (CGD) is characterized by a defect in phagocytic cells that leads to recurrent superficial and deep pyogenic infections. Burkholderia (pseudomonas) gladioli is a gram-negative bacillus in the pseudomallei group of pseudomonads that is known primarily as a plant pathogen. We report two cases of pneumonia, one accompanied by septicemia, caused by B. gladioli in patients with CGD and their successful treatment with antibiotics. We believe these represent the first reports of human disease caused by this organism. We conclude that B. gladioli should be considered a potential pathogen in patients with CGD.- - - - - - - - - - ranking = 5keywords = granulomatous disease (Clic here for more details about this article) |
6/6. Pneumonic tularemia in a patient with chronic granulomatous disease.We report the case of a 14-year-old boy with granulomatous pneumonia caused by francisella tularensis. In addition, an autosomal recessive form of chronic granulomatous disease was diagnosed. Both F. tularensis and chronic granulomatous disease are associated with pulmonary granulomas. To our knowledge, this is the first report of F. tularensis infection in a patient with chronic granulomatous disease. The relationship between these two processes is discussed.- - - - - - - - - - ranking = 7keywords = granulomatous disease (Clic here for more details about this article) |