1/5. Polyneuropathy associated with interferon beta treatment in patients with multiple sclerosis.Peripheral neuropathy has been reported as a side effect of interferon alpha, but not with interferon beta (IFNbeta) treatment. The authors assessed six patients with multiple sclerosis who developed polyneuropathy, or had exacerbation of previously subclinical neuropathy, during treatment with IFNbeta. In five patients the neuropathy improved after discontinuation of treatment and in two patients it relapsed upon rechallenge.- - - - - - - - - - ranking = 1keywords = sclerosis (Clic here for more details about this article) |
2/5. poems syndrome presenting as systemic sclerosis. Clinical and pathologic study of a case with microangiopathic glomerular lesions.A rare form of plasma cell dyscrasia characterized by the various association of polyneuropathy, organomegaly, endocrinopathy, monoclonal protein, and skin changes has been termed poems syndrome. The pathogenesis of the multisystemic features of this syndrome remains unclear. Herein is reported a case of poems syndrome with striking clinical similarities with scleroderma, and microangiopathic glomerular lesions, as well as diffuse perivascular non-amyloid deposits, which could explain certain features of the syndrome, including peripheral nerve demyelination. It is proposed that a pathogenic role might be played by a non-immunoglobulin vasculotoxic component.- - - - - - - - - - ranking = 0.8keywords = sclerosis (Clic here for more details about this article) |
3/5. Osteosclerotic myeloma variants.We describe three patients with sclerotic multiple myeloma. One patient had diffuse bone sclerosis, one had mixed sclerotic and lytic lesions, and the third had poems syndrome. The radiological, clinical, and etiological features of sclerotic myeloma variants are discussed.- - - - - - - - - - ranking = 0.2keywords = sclerosis (Clic here for more details about this article) |
4/5. Osteosclerotic "plasmocytoma" with polyneuropathy, hypertrichosis and diabetes.The combination of osteosclerosis, polyneuropathy, monoclonal immunoglobulin, hypertrichosis, serositis and a number of other symptoms is described. It seems probable that this is a special type of myeloma. Similar cases have been described in japan and out findings are compared with the Japanese picture. The age of the patients is unusually low. The M-component in the plasma is small. There is very little bence jones protein in the urine and osteolytic lesions in the skull do not seem to have occurred. The polyneuropathy may improve during treatment with cytostatic drugs.- - - - - - - - - - ranking = 0.2keywords = sclerosis (Clic here for more details about this article) |
5/5. Plasma cell dyscrasia with polyneuritis and dermato-endocrine alterations. Report of a new case outside japan.A new syndrome has been described comprising polyneuropathy, oedema, hyperpigmentation and thickening of the skin, gynaecomastia in males and amenorrhoea in females, monoclonal gammopathy, papilloedema and diabetes. There is frequent osteosclerosis with or without plasmacytoma, hepatosplenomegaly and polycythaemia. There is a good response to corticosteroids, immunosuppressive drugs and occasionally to excision or irradiation of the plasmacytoma. This syndrome was first described in japan, and is still seen predominantly there, and only occasionally in other areas. An example in a 51-year-old Spanish female is described: she had a spectacular response to prednisone and melphalan. The aetiopathogenic possibilities are discussed.- - - - - - - - - - ranking = 0.2keywords = sclerosis (Clic here for more details about this article) |