1/9. Acute fatty liver in pregnancy.When confronted with liver abnormalities during the third trimester of pregnancy, one should consider acute fatty liver of pregnancy. The differential diagnosis with (pre-)eclampsia and hellp syndrome is sometimes difficult. In these cases a liver biopsy is helpful though rarely performed during pregnancy. After delivery of the child the liver test abnormalities will ultimately disappear. Recent publications reveal that a dysfunction in the beta-oxidation of mitochondrial fatty acids may contribute to the aetiology of this rare disorder. We describe a case of acute fatty liver in pregnancy, with liver dysfunction (decreased albumin, prolonged prothrombin time) slowly returning to normal after delivery. Testing for disorders in beta-oxidation of mitochondrial fatty acids did not reveal abnormalities in mother or child.- - - - - - - - - - ranking = 1keywords = fatty liver, fatty (Clic here for more details about this article) |
2/9. Acute fatty liver of pregnancy associated with preeclampsia: management of hepatic failure with postpartum liver transplantation.Acute fatty liver of pregnancy is a potentially fatal disorder. We report a patient complicated by preeclampsia, coagulopathy, encephalopathy, and hepatorenal syndrome successfully managed by postpartum hepatic transplantation.- - - - - - - - - - ranking = 0.82945496593039keywords = fatty liver, fatty (Clic here for more details about this article) |
3/9. massive hepatic necrosis in the hellp syndrome: CT correlation.We present a patient with toxemia of pregnancy and the hellp syndrome [hemolysis (H), elevated liver enzymes (EL), and a low platelet count (LP)] resulting in massive hepatic necrosis. Cross-sectional imaging, including sonography, computed tomography, and nuclear medicine, was instrumental in the diagnosis and differentiation from hepatic abnormalities of other pregnancy related entities especially acute fatty liver of pregnancy.- - - - - - - - - - ranking = 0.16589099318608keywords = fatty liver, fatty (Clic here for more details about this article) |
4/9. magnetic resonance imaging and computed tomography scan for the diagnosis of acute fatty liver of pregnancy.magnetic resonance imaging (MRI) and computed tomography were used to diagnose fatty liver of pregnancy in a patient with preeclampsia and thrombotic thrombocytopenia purpura. The clinical course included multiple system failure that necessitated mechanical ventilation, dialysis, and plasmapheresis. The MRI picture is described in this entity for the first time. Both imaging techniques are discussed and compared.- - - - - - - - - - ranking = 0.82945496593039keywords = fatty liver, fatty (Clic here for more details about this article) |
5/9. Elevated liver enzymes and thrombocytopenia in the third trimester of pregnancy: an unusual case report and a review of the literature.A woman presented in the third trimester of pregnancy with epigastric pain, elevated liver enzymes, and thrombocytopenia. The frozen-section liver biopsy findings were compatible with acute fatty liver of pregnancy. The light and electron microscopic findings were those of preeclampsia. All clinical and laboratory abnormalities resolved before delivery.- - - - - - - - - - ranking = 0.16589099318608keywords = fatty liver, fatty (Clic here for more details about this article) |
6/9. Possible role for exchange plasmapheresis with fresh frozen plasma for maternal indications in selected cases of preeclampsia and eclampsia.A new case of a preeclamptic who developed the diagnostic criteria for the hemolytic uremic syndrome and who was treated with plasmapheresis is presented. Fourteen case reports of gravidas with preeclampsia treated by exchange plasmapheresis with fresh frozen plasma for maternal indications are reviewed. Only four cases had been reported as eclampsia or preeclampsia. The other cases had been reported as thrombotic thrombocytopenic purpura, the postpartum hemolytic uremic syndrome, or fatty liver of pregnancy. The possible role of plasmapheresis in treating very carefully selected cases of preeclampsia is discussed.- - - - - - - - - - ranking = 0.16589099318608keywords = fatty liver, fatty (Clic here for more details about this article) |
7/9. Acute fatty liver of pregnancy--survival despite associated severe preeclampsia, coma and coagulopathy.Acute fatty liver of pregnancy is the least common and most serious cause of jaundice of pregnancy. It is rare, fewer than 100 cases having been reported (Koff, 1981). There is a high probability that it is frequently misdiagnosed and categorized vaguely as some form of variant of 'toxaemia of pregnancy' which is not surprising because of its late-pregnancy onset and the production of multi-system manifestations (Holzback, 1976). In the case reported here, there was associated severe preeclampsia with fetal intrauterine death but maternal survival.- - - - - - - - - - ranking = 0.82945496593039keywords = fatty liver, fatty (Clic here for more details about this article) |
8/9. The relative fatty acid composition of serum lecithin in one woman with essential hypertension superimposed by severe preeclampsia.A hospitalized woman with essential hypertension complicated by severe preeclampsia was serially studied in the end of her pregnancy and in the puerperal period. The relative composition of serum lecithin fatty acids was analyzed by gas-liquid chromatography. In the present case, the main finding during pregnancy was a dramatic decrease of the linoleic acid parallel to a vast increase of nonessential fatty acids. Of these fatty acids, 20:3 of the oleic acid series was found in an extremely high quantity which may suggest a compensatory mechanism to reduced levels of essential polyenoic fatty acids. It was suggested that the linoleic acid decrement was mainly associated with the disease. These changes were found to be enhancements of differences earlier found between preeclamptic and normal pregnant women.- - - - - - - - - - ranking = 0.018616163534119keywords = fatty (Clic here for more details about this article) |
9/9. Transient diabetes insipidus and acute fatty liver of pregnancy.OBJECTIVE: To review the association of transient diabetes insipidus and acute fatty liver of pregnancy. DESIGN: A retrospective study. SETTING: Six women presenting with polyuria and polydipsia in the third trimester or in the immediate postpartum period, referred over a two and a half year period; five out of six were primigravida. All had raised liver transaminases and biopsy-proven acute fatty liver of pregnancy. Four out of six also had pre-eclampsia. SUBJECTS: Tertiary referral centre. MAIN OUTCOME MEASURES: There were no maternal deaths and only one fetal death. Desamino-cys-1-D-arg-8-vasopressin administration produced a reduction in urine output in all five women to whom it was administered. In all cases symptoms had resolved by the end of the fourth postpartum week. Three of the women have had subsequent pregnancies uncomplicated by either transient diabetes insipidus or acute fatty liver of pregnancy. CONCLUSIONS: The association of transient diabetes insipidus and acute fatty liver of pregnancy appears more common than previously recognised. Both may be part of the spectrum of pre-eclampsia.- - - - - - - - - - ranking = 1.3271279454886keywords = fatty liver, fatty (Clic here for more details about this article) |