1/4. Visceral leishmaniasis. Persistence of parasites in lymph nodes after clinical cure.Visceral leishmaniasis (VL) is generally associated with severe immunodeficiency (AIDS; renal, liver, and heart transplantations; haemopoietic malignancies). More rarely it can be related to an immunotolerence status such as pregnancy. Various observations report the development of leishmaniasis several months or even years after exposure to the parasite. Relapses occur rarely in patients not known to be immunocompromised, but are common after incomplete treatment. They are frequent in patients with Leishmania/hiv co-infection. Asymptomatic phases and relapses suggest that parasite can exist in the tissues for a long time before and/or after clinical onset of the disease.The mechanisms of onset of clinical leishmaniasis following exposure and infestation are highly relevant to understanding the pathology of the disease. The survival of Leishmania parasite between infection and disease or after cure is a very important issue for clinicians and epidemiologists. We describe two cases of VL occurring in a patient with lymphoma and in a pregnant woman. In both cases, parasites remained present in the lymph nodes after clinical cure.- - - - - - - - - - ranking = 1keywords = leishmaniasis (Clic here for more details about this article) |
2/4. Visceral leishmaniasis in pregnancy: a case report.Visceral leishmaniasis (VL) is endemic in the island of Sao Luis, State of Maranhao, brazil. Despite an increase in the number of VL cases, the frequency of the disease is low among pregnant women. We present here the case of a pregnant woman followed up by our group, who was treated with amphotericin b with excellent outcome.- - - - - - - - - - ranking = 0.71428571428571keywords = leishmaniasis (Clic here for more details about this article) |
3/4. Visceral leishmaniasis during pregnancy treated with meglumine antimoniate.Data on the efficacy and safety of pentavalent antimony in the treatment of visceral leishmaniasis during pregnancy are scanty. A case of visceral leishmaniasis in a 39-year-old woman in the second trimester of pregnancy is reported here. The patient was hospitalized in poor condition with high fever and pancytopenia which had lasted for 6 weeks. A bone marrow aspirate revealed numerous amastigotes and serodiagnosis for Leishmania was positive at a high titer. The patient was successfully treated with meglumine antimoniate at a daily dose of 850 mg of antimony for 20 days. She delivered at term a healthy female baby who remains in good condition at 18 months of age. Thus a dose of 850 mg of antimony, which is lower than that presently recommended, seems to be effective and non toxic to the fetus when administered at the second trimester of pregnancy.- - - - - - - - - - ranking = 0.85714285714286keywords = leishmaniasis (Clic here for more details about this article) |
4/4. Mediterranean visceral leishmaniasis in pregnancy.Visceral leishmaniasis (VL) in pregnancy is rare in Mediterranean countries. We report here 2 cases of VL in pregnant women who acquired the infection in italy. In the first case, the disease was diagnosed and treated with liposomal amphotericin b during the pregnancy. In the second case, diagnosis was established and treatment with meglumine antimoniate both undertaken shortly after delivery. The 2 infants were followed clinically and serologically for 8-9 months after birth, but no evidence of congenital VL was observed.- - - - - - - - - - ranking = 0.71428571428571keywords = leishmaniasis (Clic here for more details about this article) |