1/34. Malignant phyllodes tumor of the prostate.phyllodes tumor of the prostate is rare. We have recently experienced a case of phyllodes tumor of the prostate in a 57-year-old man who complained of urinary retention for 1 year. The epithelial components were positive reactivity for prostate specific antigen. The stromal cells showed nuclear atypia with increased mitotic activity. The tumor was diagnosed as a malignant phyllodes tumor as it invaded into the urinary bladder and rectum, and grew rapidly immediately after operation. We describe the morphological features and immunohistochemical findings of malignant phyllodes tumor and review the literature.- - - - - - - - - - ranking = 1keywords = stromal (Clic here for more details about this article) |
2/34. Stromal sarcoma of the prostate.Sarcomas of the prostate are very rare. This article describes the radiological and histopathological findings of a case of prostatic stromal sarcoma, with the appearance of a phyllodes tumour with adenoid basal cell hyperplasia. Management and follow-up of this tumour are discussed.- - - - - - - - - - ranking = 1keywords = stromal (Clic here for more details about this article) |
3/34. phyllodes tumor of the prostate. A case report and review of the literature.Prostatic cystic epithelial-stromal tumors, commonly described as phyllodes tumors of the prostate, are extremely rare lesions. They exhibit a spectrum of histological features similar to their better known counterpart in the breast. Although a benign clinical course has been emphasized in some reports, cumulative evidence in the literature indicates that these lesions should be considered neoplasms rather than atypical hyperplasia due to the frequent early recurrences with possible dedifferentiation, infiltrative growth and potential for extraprostatic spread in some cases. An individualized approach to complete excision of the tumor is needed. A case record of a patient recently treated at our medical center with a low-grade phyllodes tumor is presented and a review of the literature was done.- - - - - - - - - - ranking = 1keywords = stromal (Clic here for more details about this article) |
4/34. Cystosarcoma phyllodes of the prostate with rhabdomyoblastic differentiation.A 36-year-old man presented with recurrent urinary obstruction and an enlarged, partially cystic prostate tumour on ultrasonography. Microscopically, the tumour was composed of cystically dilated ducts with leaf-like stromal projections in the lumen. A portion of the stroma was very cellular with atypia and a high mitotic rate. In addition, there was a small focus with well differentiated rhabdomyoblasts. This case is the second description of a cystosarcoma phyllodes of the prostate with rhabdomyoblasts differentiation. With radical surgery and chemotherapy only partial remission could be obtained.- - - - - - - - - - ranking = 1keywords = stromal (Clic here for more details about this article) |
5/34. Exaggerated signet-ring cell change in stromal nodule of prostate: a pseudoneoplastic proliferation.A stromal nodule of the prostate was incidentally identified in a simple prostatectomy specimen from a 66-year-old man with benign prostatic hyperplasia. Microscopically, the nodule consisted of short spindly cells with bland nuclear features. Many of the cells in the nodule, however, contained a large, clear cytoplasmic vacuole that displaced and indented the nucleus, generating signet-ring cell morphology. Immunohistochemically, these cells were strongly positive for vimentin and weakly positive for desmin, suggesting a myofibroblastic nature. Further immunostains demonstrated the cells to be negative for cytokeratins and prostate-specific antigen, excluding the possibility of signet-ring cell carcinoma. The cytoplasmic vacuoles also stained negative for mucin production. Electron microscopy revealed no intracytoplasmic lumina. Notably, thermal effect or other signs of cellular injury, frequently associated with signet-ring cell change seen in prostate specimens obtained by transurethral resection and needle biopsy, were not appreciated in this stromal nodule. This case demonstrates that signet-ring cell change may occur in benign, hyperplastic, prostatic stromal cells in the absence of cellular damage.- - - - - - - - - - ranking = 7keywords = stromal (Clic here for more details about this article) |
6/34. Malignant phyllodes tumor of the prostate: retrospective review of specimens obtained by sequential transurethral resection.A case of malignant phyllodes tumor of the prostate in a 67-year-old man is reported. The patient was referred to a hospital for urinary retention. From material taken at three transurethral resections of the prostate (TURP), a histological diagnosis of benign prostatic hyperplasia was made. However, at the fourth TURP, phyllodes tumor was diagnosed due to the presence of elongated epithelial ducts and proliferating cellular stroma with mitosis and nuclear atypia. Two months later, total cystoprostatectomy was performed. Histologically, the tumor was composed of dysplastic stromal cells and irregularly elongated epithelial ducts. Five months later the patient developed multiple lung and pelvic lymph node metastases and died. This report documents progression to a higher histological grade of prostatic phyllodes tumor documented with sequential pathological findings obtained from four TURP and surgical specimens over about 3 years.- - - - - - - - - - ranking = 1keywords = stromal (Clic here for more details about this article) |
7/34. melanosis of the prostate gland: report of a case with neoplastic epithelium involvement.Prostate gland melanosis is an uncommon lesion and the precise histogenesis is unclear. Melanin may be found within melanocytes in the prostatic stroma, within prostatic epithelium and, rarely, in both locations. The stromal dendritic cell has been shown to contain premelanosomes and melanosomes suggesting primary melanin production by this cell. The melanogenic potential of prostatic epithelial cells has not yet been conclusively established. An example of prostatic melanosis is presented in which stromal and epithelial components were found. This dual distribution of melanin has been regarded as an indication that melanin in the epithelial cells results from phagocytosis of melanin from stromal melanocytes as a secondary phenomenon. Melanin pigment was identified not only within hyperplastic prostatic epithelium but also was found in the epithelial component of a well differentiated prostatic adenocarcinoma.- - - - - - - - - - ranking = 3keywords = stromal (Clic here for more details about this article) |
8/34. Prostatic stromal sarcoma: case report and review of the literature.We report a case of a 65-year-old man with rare prostatic stromal sarcoma in which suprapubital radical prostatectomy was performed, but neither chemotherapy nor radiation therapy were administered before or after the operation. The well-circumscribed tumor, measuring 5 cm in diameter, showed a homogeneous white grayish cut surface with a hard consistency. Histopathologically, the tumor consisted mainly of medium-sized rounded cells with a sarcomatous and epithelioid appearance intermingled with collagen fiber. Hyalinized foci were also noted in the tumor. immunohistochemistry revealed that the tumor cells were diffusely positive for vimentin and focally positive for progesterone receptor and CD34, but not for EMA, cytokeratin or estrogen receptor. No recurrence or distant metastasis of the tumor has occurred in 8 years of follow up. The tumor was diagnosed as prostatic stromal sarcoma (PSS) showing epithelioid differentiation and of a progesterone-dependent nature. Possible favorable nature of the PSS might be expected after complete resection.- - - - - - - - - - ranking = 6keywords = stromal (Clic here for more details about this article) |
9/34. carcinosarcoma of prostate. Immunohistochemical and ultrastructural observations.carcinosarcoma of the prostate is a most uncommon disease, and only a few cases have been reported previously. We report the clinical and histopathologic findings in a seventy-three-year-old man with a prostatic carcinosarcoma. The mesenchymal component of the tumor was classified as malignant fibrous histiocytoma (MFH) by electron microscopy and immunohistochemical staining methods. This is to our knowledge the first case in which the stromal component of a prostatic carcinosarcoma has been classified as MFH.- - - - - - - - - - ranking = 1keywords = stromal (Clic here for more details about this article) |
10/34. Malignant phyllodes tumor of the prostate. A case report with immunohistochemical and ultrastructural studies.phyllodes tumor of the prostate is a rare neoplasm with cellular or sarcomatoid stroma and hyperplastic glands. This lesion shares many histologic features with cystosarcoma phyllodes of the breast. Although a malignant variant of phyllodes tumor of the prostate has been described, the majority of cases have been clinically benign. We report an unusual case of phyllodes tumor of the prostate in which the stromal component underwent malignant degeneration, a finding not previously described (to our knowledge). Immunohistochemical and ultrastructural studies demonstrated smooth-muscle differentiation of the stromal cells.- - - - - - - - - - ranking = 2keywords = stromal (Clic here for more details about this article) |
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