1/6. Well-differentiated fetal adenocarcinoma of the lung.We describe the case of a 43-year-old woman with a tumor shadow in the upper lobe of the left lung. The tumor was initially suspected to be a carcinoid tumor, following percutaneous needle biopsy. Subsequently, a left upper lobectomy was performed, and a well-differentiated fetal adenocarcinoma was diagnosed histologically. Unlike the biphasic epithelial and stromal features of pulmonary blastoma, it was composed solely of malignant glands of embryonal appearance.- - - - - - - - - - ranking = 1keywords = gland (Clic here for more details about this article) |
2/6. Pulmonary well-differentiated fetal adenocarcinoma expressing lineage-specific transcription factors (TTF-1 and GATA-6) to respiratory epithelial differentiation: an immunohistochemical and ultrastructural study.A case of pulmonary well-differentiated fetal adenocarcinoma was examined with conventional histological, immunohistochemical, and ultrastructural studies that revealed the distribution of lineage-specific transcription factors (TTF-1 and GATA-6). The patient was a 33-year-old Japanese woman, who underwent resection of the right lower lobe for the lung tumor. The tumor demonstrated an organized histology mimicking the epithelial differentiation of fetal lung with peculiar glands and moruloid cell nests, without mesenchymal proliferation. adenocarcinoma cells forming the atypical glands were similar to the epithelial cells of the branching tubules in the pseudo glandular stage of the fetal lung. Distribution of TTF-1 was observed in many of the nuclei of the adenocarcinoma cells forming the glands. Tumor cells in the morula were primitive epithelial cells with some immunohistochemical neuroendocrine cell differentiation and some of them showed GATA-6-positive stains in the nuclei. In the ultrastructural study, adenocarcinoma cells showed little differentiation toward mucous cells and ciliated cells. Neuroendocrine granules were seen in a few tumor cells in the morula. In the present case, tumor cells forming the peculiar histological, molecular, and ultrastructural constructions showed partial and incomplete mimicry of the morphogenesis of respiratory epithelium.- - - - - - - - - - ranking = 4keywords = gland (Clic here for more details about this article) |
3/6. Well differentiated fetal adenocarcinoma of the lung in a 29 year old woman.This report describes a case of well differentiated fetal adenocarcinoma of the lung in a 29 year old female smoker. The histological pattern and immunohistochemical profile were consistent with well differentiated fetal adenocarcinoma and the patient made an uneventful postoperative recovery with no recurrence after 18 months. This neoplasm is a rare lung tumour that is composed of glycogen rich neoplastic glands and tubules that resembles fetal lung at 10 to 15 weeks of gestation. It is important to identify this rare variant of adenocarcinoma because it is a low grade malignancy with low associated mortality.- - - - - - - - - - ranking = 1keywords = gland (Clic here for more details about this article) |
4/6. Cyopathologic and histologic features of biphasic pulmonary blastoma: a case report.BACKGROUND: Biphasic pulmonary blastoma is a rare malignant neoplasm of debatable histogenesis. Although well described histologically, it is scarcely mentioned in the cytologic literature. CASE: A 78-year-old man reporting intermittent hemoptysis was admitted to the hospital. Chest radiography revealed a right-sided pulmonary mass. Cytologic examination of tumor specimens revealed 2 types of malignant cells. The smears were highly cellular, with a necrotic background. The stromal cells had predominantly round to ovoid or spindle-shaped nuclei and scant cytoplasm, and the nucleoli had slightly irregular borders with coarsely aggregated chromatin. The epithelial cells were arranged in sheets and glandular configurations. The cytoplasm of these cells was finely vacuolated or foamy, with indistinct cellular boundaries; eccentrically located nuclei were hyperchromatic and had irregularly shaped nucleoli. The cell block preparation showed a distinctly biphasic malignant tumor with the classic morphologic features of pulmonary blastoma. CONCLUSION: A preoperative diagnosis ofpulmonary blastoma is difficult to obtain by cytopathologic methods. A diagnosis of biphasic pulmonary blastoma should be considered whenever epithelial cells and a separate population of stromal cells are seen in a pulmonary exfoliative cytology specimen.- - - - - - - - - - ranking = 1keywords = gland (Clic here for more details about this article) |
5/6. pulmonary blastoma: an ultrastructural and immunohistochemical study with special reference to nuclear filament aggregation.A case is presented of pulmonary blastoma occurring in the right upper lobe of a 25-year-old man without distinct clinical features and laboratory abnormality. light microscopic analysis revealed that the tumor was composed of branching glands and morulae embedded in a primitive but bland mesenchyme. Immunohistochemically the epithelial cells were immunoreactive for cytokeratins, S-100 protein, protein gene product 9.5, chromogranin a, calcitonin, and Ki-67 (MIB-1); the mesenchymal cells were immunoreactive for vimentin, actin, cytokeratins, and Ki-67; and all the tumor cells were negative for p53, estrogen receptor protein, and human chorionic gonadotropin beta. Characteristically, many epithelial cells contained optically clear nuclei which were immunoreactive for biotin (M743). Electron microscopic analysis revealed that the optically clearing change was due to replacement of the central area of the nuclei by a mass of parallel-arranged 7- to 10-nm filaments, and biotin-immunoreactive products were mainly localized in the nuclear matrix. Additionally, spherical bodies were identified in the cytoplasm of the nuclear filament-aggregated cells, suggestive of an intimate pathogenetic association of the two morphological abnormalities. The similarity of the aggregated nuclear filaments to those observed in gestational endometrium and ovarian endometrioid carcinoma implies that a similar mechanism plays a role in the pathogenesis of these abnormalities.- - - - - - - - - - ranking = 1keywords = gland (Clic here for more details about this article) |
6/6. Pulmonary endodermal tumor resembling fetal lung: report of a case in a 14-year-old girl.This report describes the clinical and histologic features of a pulmonary tumor in a 14-year-old girl that is most consistent with a rare entity described in the literature as "pulmonary endodermal tumor resembling fetal lung" (PET). This tumor is composed of glycogen-rich columnar cells forming complex glands with focal festooning and mitotic activity, admixed with solid "morules" of cells with eosinophilic cytoplasm and focal nuclear clearing. Patchy tumor necrosis and a bland stroma were also present. Immunoreactivity for carcinoembryonic antigen (CEA), alpha 1-antichymotrypsin, and 12E7 was present in glandular cells and for human chorionic gondatropin (HCG), alpha 1-antichymotrypsin, and 12E7 in morular cells. Ultrastructural features are those of an epithelial tumor. Related entities have been called "pulmonary blastoma lacking sarcomatous elements" and "adenocarcinoma of fetal lung type." Most cases of PET have occurred in adults, and the histologic features thought to have prognostic significance in small published series are applied to our case, in which the patient remains well and without evidence of tumor recurrence or metastasis for 28 months following local resection as the sole treatment.- - - - - - - - - - ranking = 2keywords = gland (Clic here for more details about this article) |