1/8. Gastric antral stricture in a patient with chronic granulomatous disease.Chronic granulomatous disease (CGD) is a rare disorder of phagocytic cell oxidative metabolism. patients have recurrent infections with catalase-positive organisms and granulomatous lesions throughout the body. Gastric antrum can be an occult site of involvement. We describe a four-year old boy with chronic granulomatous disease who was admitted with the complaints of persistent vomiting and weight loss. Gastric antral narrowing was diagnosed according to radiological findings. Treatment with steroid and antibiotics yielded a good clinical response in 15 days with a relief of the obstruction. This case report emphasizes the beneficial effect of this form of therapy in preventing life-threatening obstruction of vital organs in CGD.- - - - - - - - - - ranking = 1keywords = granulomatous disease (Clic here for more details about this article) |
2/8. Corticosteroids in treatment of obstructive lesions of chronic granulomatous disease.Two patients with chronic granulomatous disease had obstructive lesions of the gastrointestinal tract, esophagus, and genitourinary tract, which were successfully treated with corticosteroids. These obstructive lesions, caused by local granuloma formation, have been reported in 18 other patients with chronic granulomatous disease, none of whom received steroids. Our first patient, a 3-year-old boy, had emesis and weight loss associated with antral narrowing and delayed gastric emptying at age 2 years. Antibiotic therapy was ineffective, but intravenous and oral corticosteroid therapy for 10 weeks resulted in clinical cure. One year later, dysuria associated with bladder neck obstruction was also treated successfully with corticosteroids. The second child, a 10-year-old boy, had dysphagia caused by distal esophageal stenosis. Corticosteroid therapy (with concomitant antibiotics) on two occasions reversed this obstruction. Granulomatous cystitis with ureteropelvic obstruction then developed, which also responded to treatment with corticosteroids and antibiotics. Despite the risk of increased susceptibility to infection, corticosteroid therapy is justified in preventing life-threatening obstruction of vital organs.- - - - - - - - - - ranking = 1keywords = granulomatous disease (Clic here for more details about this article) |
3/8. Functional gastrointestinal obstruction in a child with chronic granulomatous disease.A child with chronic granulomatous disease developed an antral-pyloric obstruction, followed a month later by a postbulbar duodenal obstruction. At both areas, there was no evidence of an anatomical lesion, and some improvement in the passage of barium was observed following glucagon and metoclopramide administration. Presumably, symptoms have resulted from a functional disturbance of gastrointestinal motility.- - - - - - - - - - ranking = 0.83333333333333keywords = granulomatous disease (Clic here for more details about this article) |
4/8. Gastric involvement in chronic granulomatous disease of childhood: demonstration by computed tomography and upper gastrointestinal studies.Gastric involvement is a rare complication of chronic granulomatous disease of childhood that may present at any time during the course of the disease. This case study presents the findings on CT and upper gastrointestinal examinations in a 10-year-old boy who developed symptoms of gastric outlet obstruction during treatment for hepatic abscesses.- - - - - - - - - - ranking = 0.83333333333333keywords = granulomatous disease (Clic here for more details about this article) |
5/8. Chronic granulomatous disease of childhood. Probable diffuse gastric involvement.Diffuse gastric infiltration in a child with CGD is described as a cause for gastric outlet obstruction.- - - - - - - - - - ranking = 0.66666666666667keywords = granulomatous disease (Clic here for more details about this article) |
6/8. Chronic granulomatous disease of childhood presenting as gastric outlet obstruction.A case of chronic granulomatous disease of childhood was first diagnosed when a 20-month-old infant developed gastric outlet obstruction. Because of the unusual clinical presentation and negative gastric mucosal biopsies, the diagnosis was delayed. A subsequent full thickness biopsy of the stomach wall which led to a correct diagnosis showed a granulomatous infiltrate in the muscularis propria. Characteristic yellow pigment-laden macrophages were seen in the gastric mucosa and pyloric lymph node. Early recognition of this chronic disorder is important not only for proper management but genetic counseling as well.- - - - - - - - - - ranking = 0.83333333333333keywords = granulomatous disease (Clic here for more details about this article) |
7/8. Isolated granulomatous disease of the stomach.A case of isolated granulomatous gastritis observed in a 66-year-old female patient is reported. The gastric granulomatosis gave rise to pyloric stenosis, and at the first explorative laparotomy the change was misdiagnosed for an inoperable tumour. gastroscopy then revealed the presence of a peptic ulcer, which healed completely on drug therapy. At the second surgical intervention undertaken on account of a relapse after 2 years, Billroth II type resection of the stomach led to complete recovery; the patient has been free from complaints ever since. It is suggested that in addition to peptic ulcer and tumour, isolated gastric granulomatosis should be taken into consideration as the underlying mechanism of pyloric stenosis.- - - - - - - - - - ranking = 0.66666666666667keywords = granulomatous disease (Clic here for more details about this article) |
8/8. Chronic granulomatous disease with gastric antral narrowing.Marked narrowing of the gastric antrum produced vomiting in a boy with chronic granulomatous disease; the antral stenosis resolved after five months of medical management. A review of the seven previously reported cases indicates that this uncommon lesion may be self-limited and should be given an exhaustive trial of nonsurgical therapy, in view of the high morbidity of surgery in these children. Antibiotics may speed resolution.- - - - - - - - - - ranking = 0.83333333333333keywords = granulomatous disease (Clic here for more details about this article) |