1/13. radiation pneumonitis following multi-field radiation therapy.The mechanisms of radiation pneumonitis have not been established. In a study on multi-field radiation therapy for lung cancer, one patient developed severe radiation pneumonitis even though the target volume was small. Radiation therapy was performed at a dose of 75 Gy in 50 fractions over five weeks. High-density areas conforming to the radiation field were observed by high-resolution CT. They were observed in the irradiated volume at doses under 20 Gy in the contralateral lung as well as in the ipsilateral lung.- - - - - - - - - - ranking = 1keywords = lung cancer, cancer (Clic here for more details about this article) |
2/13. The role of anti-epithelial cell antibodies in the pathogenesis of bilateral radiation pneumonitis caused by unilateral thoracic irradiation.Two cases of bilateral radiation pneumonitis associated with unilateral thoracic irradiation against lung cancer are described. Both patients died of respiratory failure and autopsy was performed. Histologically, bilateral diffuse alveolar damage was demonstrated in both cases, associated with marked organization of hyaline membrane in one case (case 1). In addition, numerous hyperplastic type II pneumocytes which strongly expressed cytokeratins 8, 18 and 19 were observed. In both patients' sera, antibodies against cytokeratin 8, 18 and 19 were demonstrated by a Western immunoblot. The possible association between autoantibodies to cytokeratins and diffuse alveolar damage observed in patients with bilateral radiation pneumonitis are discussed.- - - - - - - - - - ranking = 1keywords = lung cancer, cancer (Clic here for more details about this article) |
3/13. fluorine-18 FDG dual-head gamma camera coincidence imaging of radiation pneumonitis.A 69-year-old man with inoperable stage I squamous cell carcinoma of the lung underwent a radical course of radiotherapy combined with platinum-based chemotherapy. fluorine-18 fluorodeoxyglucose (FDG) imaging with a dual-head coincidence gamma camera system (Co-PET) diagnosed radiation pneumonitis 1 month after completion of radiotherapy, when the clinical and radiographic signs were atypical and more suggestive of carcinomatous lymphangitis. Treatment with oral steroids was begun based on FDG scan findings, with prompt clinical benefit as would be expected for radiation pneumonitis.- - - - - - - - - - ranking = 0.29987360066192keywords = carcinoma (Clic here for more details about this article) |
4/13. Radiation enteritis: a rare complication of the transverse colon in uterine cancer.Radiation therapy is a powerful method for the control of cancer. The utilization of abdominal or pelvic radiation has been extended, and the incidence of radiation enteritis appears to be increasing. The majority of the induced lesions is in the distal ileum, sigmoid colon, or rectum. Reported here is an unusual case of radiation enteritis which caused a severe sequelae of stricture in the transverse colon as a long-term effect of therapeutic irradiation for uterine cancer, and required a surgical resection.- - - - - - - - - - ranking = 0.2356210509752keywords = cancer (Clic here for more details about this article) |
5/13. Corticosteroid refractory radiation pneumonitis that remarkably responded to cyclosporin A.Radiation therapy is commonly used for the treatment of lung cancer. However, radiation pneumonitis frequently occurs as a complication of the radiation therapy. Although corticosteroids are widely used for the treatment of radiation pneumonitis, they are not always effective. In this report, we used cyclosporin A in the treatment of a patient suffering from steroid-refractory radiation pneumonitis. To our knowledge, this is the first report in which cyclosporin A was successfully used in the treatment of radiation pneumonitis.- - - - - - - - - - ranking = 1keywords = lung cancer, cancer (Clic here for more details about this article) |
6/13. Squamous cell carcinoma of the lung producing granulocyte colony-stimulating factor and resembling a malignant pleural mesothelioma.A 65-year-old was admitted to our hospital and was diagnosed as having squamous cell carcinoma originating in the right upper bronchus. He underwent both chemotherapy and radiation therapy, but these therapies were ineffective and thereafter the developed radiation pneumonitis and carcinomatous pleuritis. Finally, he died of bacterial pneumonia in the opposite normal lung of four months duration. From one month before his death, laboratory data indicated marked leukocytosis, and his granulocyte colony-stimulating factor (G-CSF) serum level was high. At autopsy, squamous cell carcinoma was found in the right hilus region of the lung, with a spreading form resembling a malignant pleural mesothelioma mainly occupying the pleural cavity. Based on positive staining method with specific monoclonal antibodies against G-CSF, it was considered that the leukocytosis was caused by G-CSF producing tumor.- - - - - - - - - - ranking = 1.0495576023167keywords = carcinoma (Clic here for more details about this article) |
7/13. cryptogenic organizing pneumonia after radiotherapy for breast cancer.We report a case of lasting fever and cough with pulmonary infiltrates progressing 4 months after adjuvant radiotherapy following surgery for breast cancer. Chest radiography and computed tomography demonstrated alveolar opacities outside the irradiated pulmonary area. Laboratory data revealed neutrophilia and increased levels of c-reactive protein. bronchoalveolar lavage fluid displayed increased lymphocyte counts, and transbronchial lung biopsy revealed histological patterns compatible with cryptogenic organizing pneumonia (COP). Corticosteroid therapy resulted in marked clinical improvement. From the histological and clinical findings, this case was judged to be a case of COP induced after radiotherapy for breast cancer, similar to those reported recently.- - - - - - - - - - ranking = 0.2356210509752keywords = cancer (Clic here for more details about this article) |
8/13. A case of metachronous bilateral breast cancer with bilateral radiation pneumonitis after breast-conserving therapy.We report a patient with metachronous bilateral breast cancer who has twice developed radiation pneumonitis after breast-conserving therapy for each breast. The patient was a 48-year-old woman, who presented with Stage I right breast cancer. After wide excision of the right breast tumor and dissection of level I axillary lymph nodes, systemic therapy with oral 5-FU and tamoxifen was started. Subsequently, tangential irradiation with a total dose of 50 Gy in 25 fractions was given. Seven months after irradiation, she developed respiratory symptoms and radiation pneumonitis was diagnosed. The symptoms resolved with oral prednisolone. Thirty months after the right breast cancer treatment, Stage I left breast cancer was diagnosed. After wide excision of the left breast tumor and partial removal of the level I axillary lymph nodes, the same oral systemic chemo-hormonal therapy was initiated. Thereafter, tangential irradiation with a total dose of 50 Gy in 25 fractions was given. Four months after irradiation, she developed respiratory symptoms. A chest X-ray showed an area of increased density in the left lung consistent with radiation pneumonitis. The symptoms were mild and they improved spontaneously without medication. Although there is insufficient evidence to justify or withhold whole breast radiation therapy from patients with a history of contralateral breast cancer and radiation pneumonitis, it is essential to discuss the adequacy of whole breast irradiation and the possibility of alternative approaches, such as breast-conserving surgery without irradiation or partial breast irradiation for this rare condition.- - - - - - - - - - ranking = 0.3534315764628keywords = cancer (Clic here for more details about this article) |
9/13. Case report: non-malignant cause of brachiocephalic vein compression following treatment for lung cancer.Obstruction of venous return in the mediastinum or thoracic inlet is well recognized, particularly in oncological practice. In most cases the obstruction is of the superior vena cava. For such venous obstruction to occur following treatment for lung cancer usually implies malignant lymph node involvement and therefore a grave prognosis. This report describes a patient who developed unilateral signs of impaired venous return from the head, upper trunk and upper limb following treatment for lung cancer. The cause was found to be compression of the left brachiocephalic vein by normal anatomical structures as a result of mediastinal shift following pulmonary lobectomy and radiotherapy. This case, together with others reported in the medical literature, suggests that the development of isolated brachiocephalic vein obstruction does not necessarily have the same ominous implications as the development of superior vena caval obstruction.- - - - - - - - - - ranking = 6keywords = lung cancer, cancer (Clic here for more details about this article) |
10/13. Migratory bronchiolitis obliterans organizing pneumonia after unilateral radiation therapy for breast carcinoma.We report the case of a 59 year old woman who developed cough, dyspnoea and fever with patchy migratory airspace infiltrates, 2 months after right breast radiation therapy for breast carcinoma. lung infiltrates were initially localized in the irradiated area and spread to the contralateral lung. lung biopsy, performed in an unirradiated area of the contralateral lung 9 months after completion of radiotherapy, revealed a typical histological pattern of bronchiolitis obliterans organizing pneumonia. No cause of bronchiolitis obliterans organizing pneumonia other than radiation was found. Treatment with corticosteroids resulted in rapid clinical improvement and complete resolution of airspace opacities. This case suggests that localized lung irradiation might trigger the development of a bilateral lung disease, with a histological pattern of bronchiolitis obliterans organizing pneumonia.- - - - - - - - - - ranking = 0.74968400165479keywords = carcinoma (Clic here for more details about this article) |
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