1/3. Gadodiamide-based coronary angiography in a patient with severe renal insufficiency.The risk of contrast-induced nephropathy (CIN) is extremely high in patients with preexisting renal insufficiency. gadolinium-based coronary angiography has been proposed as an approach to prevent CIN in this high risk subgroup. We report the use of gadodiamide-based coronary angiography in a patient with severe renal insufficiency and in vitro comparisons of combinations of iodinated contrast with gadodiamide and saline.- - - - - - - - - - ranking = 1keywords = nephropathy (Clic here for more details about this article) |
2/3. The pathology of jaundice-related renal insufficiency: cholemic nephrosis revisited.The spectrum of jaundice-related nephropathy can range from limited proximal tubulopathy to renal failure. The latter condition was known as cholemic nephrosis in the early literature on this subject. Elevated plasma concentrations of bile salts and bilirubin conjugated or not, putatively mediate the nephrotoxicity. A functional derangement of renal tubule cells is considered to underlie the nephropathy, but published data on renal histology are scarce. In this report, we describe the renal biopsies of two jaundiced patients with reduced creatinine clearance, and we critically review the literature on the pathogenesis of jaundice-related nephropathy. Normal renal architecture, indicating functional renal impairment, and extensive renal tubule necrosis were both observed in jaundice-related renal failure. The findings fit the original description of cholemic nephrosis. Both bilirubin and bile salts are potential nephrotoxins in animal models, but their precise role in the pathogenesis of jaundice-related nephropathy is not known. patients with bilirubin plasma concentrations >20 mg/dL, a low serum albumin concentration or endo-toxemia, could be more prone to develop renal failure due to jaundice-related tubulopathy. In conclusion, jaundice-related nephropathy is essentially a tubulopathy, but the exact nature of the Pathogenesis is still uncertain.- - - - - - - - - - ranking = 5keywords = nephropathy (Clic here for more details about this article) |
3/3. Use of gadolinium-based angiography for renal artery stenting in a patient with renal insufficiency: A case report.The number of percutaneous diagnostic and interventional procedures performed continues to increase. Despite the use of various methods to reduce the incidence of contrast-induced nephropathy, the development of renal failure remains a significant problem with iodinated-based contrast agents. patients with a baseline renal insufficiency are at considerably higher risk of permanent renal deterioration following exposure to iodinated contrast. The authors report a successful case of percutaneous stenting of the renal artery using a gadolinium-based contrast agent in a high-risk patient with renal insufficiency.- - - - - - - - - - ranking = 1keywords = nephropathy (Clic here for more details about this article) |