1/9. Treatment of parainfluenza virus 3 pneumonia in a cardiac transplant recipient with intravenous ribavirin and methylprednisolone.A 59-year-old man developed a lower respiratory tract infection 10 years after orthotopic cardiac transplantation. He did not respond to broad-spectrum antibiotic and antifungal treatment. Parainfluenza virus type 3 was the causative organism, and he was successfully treated with intravenous ribavirin and methylprednisolone.- - - - - - - - - - ranking = 1keywords = respiratory tract infection, respiratory tract, tract infection, tract (Clic here for more details about this article) |
2/9. ribavirin therapy of adult respiratory syncytial virus pneumonitis.Respiratory syncytial virus is a common respiratory tract pathogen in infants. Pulmonary infection in adult and elderly populations can occur with severe and even fatal pneumonitis having been reported in several recent outbreaks. We present a previously healthy adult patient who developed respiratory syncytial virus pneumonia severe enough to require mechanical ventilation. Antiviral therapy with aerosolized ribavirin was successfully undertaken and the patient recovered completely. Respiratory syncytial virus infection should be considered in the differential diagnosis of atypical adult pneumonias. Aerosolized ribavirin therapy may be beneficial in treatment.- - - - - - - - - - ranking = 0.082962659027971keywords = respiratory tract, tract (Clic here for more details about this article) |
3/9. Interferon production in children with respiratory syncytial, influenza, and parainfluenza virus infections.To better understand the recovery process of infants with lower respiratory tract disease due to respiratory syncytial virus, the production of interferon by 129 children (ages 10 days to 24 months) with RSV infection was compared to that of 20 children with influenza (ages 1 to 36 months), and 37 children with parainfluenza virus infection (ages 4 to 66 months). Interferon assays of 285 nasal washes from children with RSV revealed that interferon production occurred in only 5 (4%) of the children. Significantly more children infected with infleunza virus, 55% (P less than 0.001), and parainfluenza virus, 30% (P less than 0.001), produced interferon. In addition, the quantity of interferon produced by children with RSV (geometric mean titer = 2) was significantly less than that of children with influenza (GMT = 26.8, P less than 0.001) and parainfluenza virus (GMT = 23.5, P less than 0.001). In the children infected with RSV, in constrast to those with influenza, interferon detection was not associated with diminished shedding of virus.- - - - - - - - - - ranking = 0.082962659027971keywords = respiratory tract, tract (Clic here for more details about this article) |
4/9. Respiratory syncytial virus and ribavirin therapy: winter 1987-spring 1988. A report of 74 cases treated at Providence Hospital, Anchorage, alaska.Seventy-four pediatric cases of Respiratory Syncytial Virus lower respiratory tract infection were treated at Providence Hospital, Anchorage, alaska between September 1, 1987 and April 30, 1988. These patients are described with illustrative case reports. Twenty-one patients were treated with ribavirin and these patients are further analyzed as a special interest group. A disproportionate number of the ribavirin treated group were Alaskan Natives. In the discussion we address concerns of possible toxicity of ribavirin and current recommendations for patient selection for treatment with ribavirin.- - - - - - - - - - ranking = 1keywords = respiratory tract infection, respiratory tract, tract infection, tract (Clic here for more details about this article) |
5/9. Respiratory syncytial virus-induced acute lung injury in adult patients with bone marrow transplants: a clinical approach and review of the literature.acute lung injury induced by respiratory syncytial virus (RSV) is a major cause of morbidity and mortality in patients who have undergone bone marrow transplantation. Twenty-nine of the 74 patients who received bone marrow transplants at the University of minnesota during a 1-year period developed evidence of acute lung injury, and RSV was identified as the cause in 8. We discuss the clinical course of these 8 patients and offer a clinical approach to RSV infection occurring after bone marrow transplantation. We also review the immune response to infection with RSV and relate this information to the nature and degree of immunosuppression present in patients undergoing this type of transplantation. We found bronchoalveolar lavage with rapid antigen detection to be particularly useful for the prompt diagnosis of this serious infection. The virus was obtained from the lower respiratory tract of each patient and was identified in lavage effluent by culture and by antigen detection (ELISA). The mean time to a positive culture was 6 days, while detection of antigens of respiratory syncytial virus by ELISA was completed within 18 hours in all cases. The clinical progression of the illness in immunocompromised patients appears to be the same as in non-immunocompromised persons: upper respiratory tract infection and illness precede lower respiratory tract infection and acute lung injury. Seven of our 8 patients had upper respiratory tract symptoms or abnormal sinus radiographs, and upper respiratory specimens (cultures and ELISA from nasopharynx, throat, and sputum) were positive in 5 of 8 patients. Six patients developed RSV-induced lung injury before marrow engraftment; 4 of them had respiratory failure requiring mechanical ventilation and died, including 3 in whom RSV was eliminated from the lower respiratory tract following treatment with ribavirin aerosol. Two additional pre-engraftment patients had only relatively mild lung injury 4 days after beginning treatment with ribavirin for RSV infection in the upper respiratory tract. Their recovery suggests that early treatment may ameliorate RSV-induced lung injury. The remaining 2 patients developed lung injury after marrow engraftment. Both of these patients had clear chest radiographs, responded clinically to ribavirin, and survived. RSV is a potentially treatable cause of life-threatening lung injury, if the physician is aggressive in identifying the virus in the upper respiratory tract before evidence of lung injury appears. Rapid detection methods are essential when bone marrow transplant patients have fever along with signs, symptoms, or radiographic indications of nasal or sinus disorders.(ABSTRACT TRUNCATED AT 400 WORDS)- - - - - - - - - - ranking = 2.4148325141629keywords = respiratory tract infection, respiratory tract, tract infection, tract, upper (Clic here for more details about this article) |
6/9. Characterization of prolonged apneic episodes associated with respiratory syncytial virus infection.We used high-speed polygraphic recordings to document in detail the sequence of events during prolonged apneic spells in two infants with respiratory syncytial viral (RSV) infection. Also, we elicited upper airway reflexes by stimulating the airway with saline during sleep. Spontaneous prolonged apneic spells were recorded in both infants, and these consisted of two distinctly different apnea types. A number of similarities between apnea of prematurity, upper airway reflex apnea and the apneas in these two infants with RSV infection suggests the possibility that these various kinds of apnea may have related causal mechanisms.- - - - - - - - - - ranking = 7.6876092072013E-6keywords = upper (Clic here for more details about this article) |
7/9. Respiratory syncytial virus infection: a cause of respiratory distress syndrome and pneumonia in adults.Respiratory syncytial virus (RSV) infection, an important and sometimes lethal disease of infants and children, generally causes a milder and self-limited syndrome of cough, nasal congestion and fever in adults. While some evidence suggests that RSV may be responsible for more serious respiratory illness in the elderly and chronically ill, it has not been shown to cause life-threatening respiratory tract disease in previously healthy adults. This report describes a previously healthy woman who experienced the acute onset of right lower lobe pneumonia which rapidly progressed to the adult respiratory distress syndrome (ARDS). Acute and convalescent serology showed RSV was the cause of the respiratory tract illness. michigan Department of public health records revealed six additional cases of adult bilateral pneumonia with diagnostic antibody titers to RSV, with or without coinfection with a second organism. These data suggest that RSV may be an under-recognized cause of lower respiratory tract disease in adults.- - - - - - - - - - ranking = 0.24888797708391keywords = respiratory tract, tract (Clic here for more details about this article) |
8/9. Reye's syndrome associated with respiratory syncytial virus infection.An upper respiratory tract infection in a 22-month-old boy was followed by rapid loss of consciousness, hypoglycaemia, uraemia, and death. Necropsy examination showed fatty change of liver and kidneys, severe cerebral oedema, bronchiolitis, and endocardial fibroelastosis affecting the left ventricle. Immunofluorescence staining showed infection with respiratory syncytial virus (RSV). The clinical and pathological findings were those of Reye's syndrome, not previously reported accompanying RSV infection.- - - - - - - - - - ranking = 1.0000038438046keywords = respiratory tract infection, respiratory tract, tract infection, tract, upper (Clic here for more details about this article) |
9/9. Cardiac arrhythmias as a manifestation of acquired heart disease in association with paediatric respiratory syncitial virus infection.Respiratory syncitial virus (RSV) is a common cause of upper and lower respiratory tract infection in infants. An association between RSV bronchiolitis and cardiac arrhythmias has been described but is rare. A further case of an infant with supraventricular tachycardia in association with culture-positive respiratory syncitial virus bronchiolitis is reported. This case prompted a review of the two other cases of arrhythmia associated with RSV infection seen at this institution and a review of all other published cases.- - - - - - - - - - ranking = 1.0000038438046keywords = respiratory tract infection, respiratory tract, tract infection, tract, upper (Clic here for more details about this article) |