1/115. Unusual onset of rheumatoid arthritis with diffuse pulmonary nodulosis: a diagnostic problem.We describe a case of a 50-year-old woman presenting articular manifestations of rheumatoid arthritis associated with severe interstitial lung involvement related to multiple pulmonary nodules. diagnosis of diffuse pulmonary rheumatoid nodulitis was made only after video assisted thoracoscopic lung biopsies.- - - - - - - - - - ranking = 1keywords = arthritis (Clic here for more details about this article) |
2/115. Multiple rheumatoid papules characteristic of the early stage of rheumatoid vasculitis.The rheumatoid papule has recently been described as the skin manifestation of rheumatoid arthritis (RA). The papules represent leukocytoclastic vasculitis and necrobiosis clinicopathologically. We report a 59-year-old Japanese woman with multiple recurrent rheumatoid papules located on the bilateral extensor forearms in correlation with the level of RA activity and as a cutaneous manifestation of rheumatoid vasculitis. These papules appeared prior to other cutaneous manifestations. It was suggested that rheumatoid papules represent the early stage of rheumatoid vasculitis and that they are a reliable early clinical marker of rheumatoid vasculitis.- - - - - - - - - - ranking = 0.2keywords = arthritis (Clic here for more details about this article) |
3/115. Successful treatment of methotrexate induced nodulosis with D-penicillamine.Accelerated nodulosis is a recognized complication of methotrexate (MTX) therapy in rheumatoid arthritis (RA). We describe 3 patients with accelerated nodulosis treated with D-penicillamine (D-Pen) while continuing MTX. The combination of D-Pen with MTX therapy resulted in regression of subcutaneous nodules in all patients, disappearance of pulmonary nodules in one patient, and resolution of vasculitic lesions in 2 patients. Clinical response was observed within the first few weeks of therapy and usually required moderate doses (500 mg/day). Our observations suggest that addition of D-Pen to MTX therapy can be an alternative therapeutic option for accelerated nodulosis in patients with RA.- - - - - - - - - - ranking = 0.2keywords = arthritis (Clic here for more details about this article) |
4/115. colchicine therapy for low-dose-methotrexate-induced accelerated nodulosis in a rheumatoid arthritis patient.Accelerated nodulosis developed on the fingers of a woman successfully treated with low dose methotrexate for rheumatoid arthritis. colchicine therapy resulted in regression of these nodules for twelve months. To our knowledge, this is the first report in the dermatological literature on this relatively new entity in which the skin is also involved.- - - - - - - - - - ranking = 1keywords = arthritis (Clic here for more details about this article) |
5/115. Rheumatoid arthritis and simultaneous aortic, mitral, and tricuspid valve incompetence.We describe a 72-year-old woman with aortic, mitral, and tricuspid valve incompetence secondary to a rheumatoid granulomata. The cardiac valvular lesions developed simultaneously and deteriorated rapidly. The patient died after a transient relief of symptoms by high dose steroid therapy.- - - - - - - - - - ranking = 0.8keywords = arthritis (Clic here for more details about this article) |
6/115. Relapse of cutaneous leishmaniasis in a patient with an infected subcutaneous rheumatoid nodule.Cutaneous leishmaniasis is a protozoal infection generally considered to be limited to the skin. In israel, the disease is common in geographically defined areas and is caused predominantly by leishmania major. Sporotrichoid subcutaneous spread has been reported but is uncommon. We describe a patient with rheumatoid arthritis, treated with methotrexate and prednisone, in whom numerous rheumatoid nodules concomitant with cutaneous leishmaniasis were found, mimicking sporotrichoid spread of the disease. In a rheumatoid nodule that was examined by electron microscopy, Leishmania parasites were found at intracellular and extracellular locations. This observation supports the hypothesis that cutaneous leishmaniasis parasites persist after clinical cure of the disease and may re-emerge as a result of immunosuppression.- - - - - - - - - - ranking = 0.2keywords = arthritis (Clic here for more details about this article) |
7/115. Accelerated nodulosis during methotrexate therapy for refractory rheumatoid arthritis. A case report.Accelerated nodulosis (AN) is a potential complication of methotrexate (MTX) therapy for rheumatoid arthritis (RA). We report on a 62-year old man affected by seropositive RA who developed AN after five months of MTX treatment. MTX-dose reduction was followed by rapid regression of the skin nodules. The Authors describe the typical features of AN and discuss on the pathogenetic mechanisms.- - - - - - - - - - ranking = 1keywords = arthritis (Clic here for more details about this article) |
8/115. aortic valve rheumatoid nodules producing clinical aortic regurgitation and a review of the literature.The majority of cardiac involvement in rheumatoid arthritis (RA) is an incidental finding at postmortem, as less than 3% of patients with RA have clinical cardiac signs or symptoms. Most cardiac involvement in RA involves the pericardium and has been known since Charcot first described an RA patient with pericarditis in 1881. Cardiac involvement takes two different forms: non-specific inflammatory changes and specific granuloma formation. Specific rheumatoid nodules in the heart are an infrequent complication of RA. This is the first case report of a surgically excised heart valve with rheumatoid nodules. A 74-year-old RA patient with a high seropositive rheumatoid factor presented with severe aortic regurgitation and underwent a valve replacement. The native aortic valve showed significant stenosis with multiple, classic rheumatoid nodules.- - - - - - - - - - ranking = 0.2keywords = arthritis (Clic here for more details about this article) |
9/115. Benign rheumatoid nodules of childhood.The nodules associated with rheumatoid arthritis and rheumatic fever appear with other signs of active rheumatic disease. rheumatoid nodule-like lesions irrelevant to rheumatoid disease occasionally occur in children who are well and have no complaints associated with rheumatoid diseases. Laboratory tests are normal. Children with benign rheumatoid nodule are not at increased risk for rheumatic disease. No therapy or prophylaxis is required. We present a two-year-old girl with a subcutaneous nodule on the right pretibial region who was diagnosed with clinical and histological findings.- - - - - - - - - - ranking = 0.2keywords = arthritis (Clic here for more details about this article) |
10/115. Rheumatoid disease without arthritis.A middle-aged man developed multiple subcutaneous rheumatoid granulomata, high titer of rheumatoid factor, diffuse interstitial pulmonary fibrosis and digital clubbing in the absence of clinicoradiological evidence of synovial disease. This patient supports the concept of rheumatoid disease without arthritis.- - - - - - - - - - ranking = 1keywords = arthritis (Clic here for more details about this article) |
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