1/22. Necrotizing sialometaplasia.Two cases of necrotizing sialometaplasia are reported together with a review of the literature. This self-limiting benign lesion is easily confused with malignant tumors. The lesions are characterized histologically by an extensive necrosis of the salivary gland tissue together with squamous metaplasia of the ducts. The present report of two females who had intense pain in the initial phase differs from previous reports concerning age and symptoms. The importance of rather extensive biopsy specimens is stressed. Antibiotic treatment appears to be insignificant. A clinical history of allergy and a dominance of eosinophilic granulocytes in the inflammatory exudate in both cases may indicate an allergic etiology.- - - - - - - - - - ranking = 1keywords = necrotizing (Clic here for more details about this article) |
2/22. Necrotizing sialometaplasia of parotid gland: a possible vasculitic cause.Necrotizing sialometaplasia at the parotid gland location is rare and simulates malignant disease. If it is seen at this location, the causes may be previous dental or parotid gland surgical procedures, which result in blood vessel injuries and thrombosis. We report a parotid gland necrotizing sialometaplasia of a 17-year-old girl, possibly caused by primary vascular damage or vasculitis.- - - - - - - - - - ranking = 1keywords = necrotizing (Clic here for more details about this article) |
3/22. Antineutrophil cytoplasmic autoantibody-associated vasculitis presenting as sjogren's syndrome.A 63-year-old woman, in whom a diagnosis of sjogren's syndrome was initially made, proved to have systemic vasculitis with salivary gland involvement and necrotizing and crescentic glomerulonephritis. Antineutrophil cytoplasmic autoantibodies (ANCA) against myeloperoxidase were positive. ANCA-associated vasculitis should be considered in the differential diagnosis of sjogren's syndrome. A positive finding on immunoassay for ANCA against myeloperoxidase or proteinase 3 may help establish the diagnosis.- - - - - - - - - - ranking = 1keywords = necrotizing (Clic here for more details about this article) |
4/22. Necrotizing sialometaplasia of the mandible.A brief review of the literature on necrotizing sialometaplasia has been presented. A patient with necrotizing sialometaplasia of the retromolar pad is reported. This is the first such lesion to be described in an oral site other than the palate. Clinical, histologic, and etiologic aspects of the lesion have veen discussed.- - - - - - - - - - ranking = 2keywords = necrotizing (Clic here for more details about this article) |
5/22. NECROTIZING SIALOMETAPLASIA.Nonhealing palatal ulcerations in two white male patients, one 50 and another 58 years of age, were clinically suspected of being malignant, even after the initial biopsies were negative. Second biopsies in each case confirmed the original opinions, but the lesions were diagnosed specifically as "necrotizing sialometaplasia". This is an interesting condition of uncertain etiology that can mimic cancer, both clinically and microscopically. The condition heals spontaneously. It should be considered in a differential diagnosis of suspicious lesions of the palate.- - - - - - - - - - ranking = 1keywords = necrotizing (Clic here for more details about this article) |
6/22. Necrotizing sialometaplasia affecting the minor labial glands.A case of necrotizing sialometaplasia of the lower lip, a previously unreported location for this lesion, is presented. In the past, other cases of this benign process occuring in this site may have been confused with squamous-cell or mucoepidermoid carcinoma. In order to arrive at the correct diagnosis, an ample biopsy of the lesion is mandatory.- - - - - - - - - - ranking = 1keywords = necrotizing (Clic here for more details about this article) |
7/22. Necrotizing sialometaplasia.An example of palatal necrotizing sialometaplasia is presented, and the clinical and microscopic features suggestive of squamous-cell carcinoma and mucoepidermal carcinoma are noted. The patient's health status, as shown by a rather thorough work-up, was unremarkable during the period which would seem to preclude a systemic etiology of this disease. The resolution of the lesion with minimal therapy is documented.- - - - - - - - - - ranking = 1keywords = necrotizing (Clic here for more details about this article) |
8/22. Necrotizing sialometaplasia.Three additional cases of necrotizing sialometaplasia are discussed. Clinical appearance of the lesion is not diagnostic. microscopy shows pseudoepitheliomatous hyperplasia, squamous metaplasia, and acinar necrosis. No atypia is seen. Mucoepidermoid and squamous cell carcinoma are frequent wrong diagnoses. All reported lesions have healed without recurrence regardless of therapy.- - - - - - - - - - ranking = 1keywords = necrotizing (Clic here for more details about this article) |
9/22. Necrotizing sialometaplasia: review of the literature and report of nonulcerative case.A review of the literature and a report of a case of necrotizing sialometaplasia of the hard palate is presented. Because necrotizing sialometaplasia may be misdiagnosed as squamous cell carcinoma or mucoepidermoid carcinoma, it is important that the clinician and pathologist take the necessary precautions to prevent any further mutilative surgery for this benign disease entity.- - - - - - - - - - ranking = 2keywords = necrotizing (Clic here for more details about this article) |
10/22. Necrotizing sialometaplasia after bronchoscopy.Since the introduction of necrotizing sialometaplasia into the literature as a distinct pathologic entity in 1975, there have been several reports containing microscopic findings consistent with the disease primarily of the hard palate, but also of the soft palate, major salivary glands, retromolar pad of the mandible, and mucous glands of the nasal cavity. Localized ischemia appears to be a common link. All reported lesions heal with or without surgical intervention. Generous incisional biopsy specimens should be taken and aggressive surgery should be avoided.- - - - - - - - - - ranking = 1keywords = necrotizing (Clic here for more details about this article) |
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