1/26. Fine-needle aspiration cytology of polymorphous low-grade adenocarcinoma of the tongue.The cytologic features derived from a fine-needle aspiration of polymorphous low-grade adenocarcinoma (PLGA) of the base of the tongue are described. The tumor cells were composed of cuboidal epithelial cells and short, spindle-shaped myoepithelial-like cells, and they formed large cell clusters. In the central portion of the clusters, myxoid materials were present, and palisading tumor cells occasionally surrounded them. Histological examination revealed solid proliferation of the epithelial cuboidal and spindle cells. The former frequently formed tubular and papillary structures. The tumor was not encapsulated, and invasion of adjacent muscle tissue was noted. Although the cytologic differentiation from cellular variants of pleomorphic adenoma and myoepithelioma is difficult, the feature of palisading tumor cells may be useful in the differential diagnosis.- - - - - - - - - - ranking = 1keywords = tongue (Clic here for more details about this article) |
2/26. Malignant oncocytoma of a minor salivary gland: an unusual presentation at the base of the tongue.In contrast to malignant oncocytomas of the parotid gland, malignant oncocytomas arising from minor extraparotid glandular tissue are rare. The latter may display a locally aggressive behaviour as well as a variable tendency to develop secondary cervical lymph nodes. We report a new case of malignant oncocytoma in a 43-year-old man presenting with greatly enlarged cervical lymph nodes accompanied by a poorly defined swelling at the base of the tongue microscopically identified as a malignant oncocytoma. The diagnosis was strongly supported by the ultrastructural features of the cells almost completely filled with mitochondria. The cervical mass was excised, and the patient has suffered no recurrence for nearly 2 years after surgical treatment.- - - - - - - - - - ranking = 1keywords = tongue (Clic here for more details about this article) |
3/26. Late scar recurrence in mucoepidermoid carcinoma of base of tongue.recurrence in mucoepidermoid carcinoma of the salivary gland after 15 years is rare and present difficult therapeutic decisions. A rare case of mucoepidermoid cancer of the base of the tongue that recurred loco-regionally after 20 years and was managed judiciously by a planned combined modality approach is presented.- - - - - - - - - - ranking = 1keywords = tongue (Clic here for more details about this article) |
4/26. Adenoid cystic carcinoma of the tongue.Malignant tumours of the salivary glands in children are extremely rare. We present here a 12-year-old girl initially diagnosed as pleomorphic adenoma on fine needle aspiration biopsy, and adenoid cystic carcinoma (ACC) after the lesion was excised and examined by histopathology. A wide resection of the lesion and bilateral supraomyohyoid neck dissection was performed. To our knowledge this is one of the youngest patients with ACC of the minor salivary glands. Due to its benign histological appearance, the biological agressiveness of ACC is usually underestimated. Although fine needle aspiration cytology (FNAC) is very valuable in diagnosis, cytological variations of pleomorphic adenoma must be considered. ACC of the tongue in a young age group should be treated with wide resection and selective neck dissection if the tumour is localized in places where the risk of metastasis is increased and if there is a clinically palpable lymph node. In such cases the clinician should not avoid radical operations even in a young patient.- - - - - - - - - - ranking = 1keywords = tongue (Clic here for more details about this article) |
5/26. Papillary cystadenocarcinoma arising from minor salivary glands in the anterior portion of the tongue: a case report.Papillary cystadenocarcinoma is a rare malignant neoplasm of the salivary gland. We report a case of papillary cystadenocarcinoma arising from the minor salivary gland in the anterior portion of the tongue of a 72-year-old male patient with a history of adenocarcinoma of the colon and prostate. Further, we discussed histopathological and clinical features of this lesion, and reviewed the literature.- - - - - - - - - - ranking = 1keywords = tongue (Clic here for more details about this article) |
6/26. Response to paclitaxel and carboplatin in metastatic salivary gland cancer: a case report.BACKGROUND: Malignant tumors of the salivary gland are rare entities that are treated primarily by surgical resection. For patients with recurrent or unresectable disease, options include radiation therapy or chemotherapy; however, responses are few and of short duration. patients with metastatic disease have been treated with chemotherapy, but, again, response rates have been low and of short duration. methods: A 52-year-old man was seen with a mass on his tongue. A biopsy revealed adenocarcinoma of a minor salivary gland. Ten months after surgical resection, neck dissection, and radiation therapy, the patient was found to have metastatic disease to the lung. Chemotherapy was initiated with carboplatin and paclitaxel. RESULTS: The patient obtained a complete response after six cycles of carboplatin and paclitaxel. CONCLUSIONS: The use of carboplatin and paclitaxel in the setting of metastatic salivary gland cancer is a viable option.- - - - - - - - - - ranking = 0.2keywords = tongue (Clic here for more details about this article) |
7/26. Hyalinizing clear cell carcinoma of the base of the tongue.Clear cell carcinoma of the salivary glands is a rare tumour that represents less than one per cent of all salivary tumours. They are divided into a biphasic, epithelial-myoepithelial carcinoma and a monophasic pattern which may be myoepithelial or ductal in origin. The latter is accompanied by prominent fibrohyaline stroma and has been described recently as hyalinizing clear cell carcinoma (HCCC). Most of the HCCC occur in the oral cavity, and are associated with minor salivary glands, unlike the biphasic pattern which is more common in the major salivary glands. In the oral cavity, the commonest site is the palate followed by the lips and the buccal mucosa. Its occurrence in the oropharynx and the larynx is extremely rare.- - - - - - - - - - ranking = 0.8keywords = tongue (Clic here for more details about this article) |
8/26. Hyalinizing clear cell carcinoma of salivary gland: an aggressive variant.Although hyalinizing clear cell carcinoma (HCCC) had been previously illustrated by several authors, it was not until 1994 that this tumour was characterized by Milchgrub et al. [Am J Surg Pathol (1994),18,74] and separated from the heterogeneous group of clear cell carcinomas described in the literature. HCCC is a distinctive infiltrative low-grade, monomorphic, glycogen-rich clear cell carcinoma with prominent stromal hyalinization occurring most often in the minor salivary glands of adult women. A case of hyalinizing clear cell carcinoma arising in the tongue of an adult female is described with special reference to the presence of minor foci of mitotic activity, necrosis and anaplasia in this otherwise typical low-grade carcinoma. Widespread metastases and death within a year of initial presentation in this case suggests that there may be a subset of this indolent tumour in which these features are associated with a poor prognosis.- - - - - - - - - - ranking = 0.2keywords = tongue (Clic here for more details about this article) |
9/26. Clear cell carcinoma of minor salivary gland of the tongue.The case of a clear cell carcinoma of a minor salivary gland, at the basis of the tongue, is described, which represents 1% of malignant tumours of salivary glands. The biological behaviour is not very aggressive and development, which is very slow, is usually asymptomatic, and, indeed, the tumour often reaches considerable dimensions before being diagnosed. There are rare cases of local recurrence and distant metastases. Cases of salivary glands which have become sites of secondary localization of a clear cell tumour, originating in the kidneys, have been described. The interest in the form described here stems from the slow evolution and the considerable dimensions reached by the tumour before being diagnosed, despite development in a breathing or digestive area such as the oralpharyngeal tract. In the present case, computed axial tomography and nuclear magnetic resonance were used to reach the diagnosis. The patient was submitted to surgical treatment. In the differential diagnosis, it is necessary, from a pathological point of view, to take into consideration other neoplastic formations, such as acinar cell adenocarcinoma, epithelial-myoepithelial carcinoma, clear cell oncocytoma, sebaceous adenoma and sebaceous carcinoma.- - - - - - - - - - ranking = 1keywords = tongue (Clic here for more details about this article) |
10/26. Mucoepidermoid carcinoma metastatic to the skin. An histologic mimic of a primary sweat gland carcinoma.Mucoepidermoid carcinomas are tumors that usually arise from salivary glands and have a characteristic histologic pattern of atypical squamous cells showing focal mucin production. Mucoepidermoid carcinomas are uncommon neoplasms that metastasize most commonly via lymphatic and hematogenous channels. We report what we believe to be the first case of a mucoepidermoid carcinoma arising from a sublingual salivary gland with metastasis to a distant site on the skin. The patient is a 58-year-old black woman who was initially diagnosed with a high grade mucoepidermoid carcinoma of the salivary glands of the tongue. Approximately 18 months after presentation, and 6 months following surgery, chemotherapy, and radiation therapy, the patient noted a firm nodule on her flank. biopsy showed malignant squamous epithelium. periodic acid-Schiff and alcian blue stains revealed focal mucin production. The histologic differential diagnosis included an eccrine carcinoma, mucin-producing adenocarcinoma with squamous differentiation, a primary cutaneous adenosquamous (mucoepidermoid) carcinoma and a malignant mixed tumor of the skin. Clinical correlation was essential in making the correct diagnosis. While mucoepidermoid carcinomas only uncommonly show distant metastasis, and even less frequently involve the skin, this entity should be included in the differential diagnosis of mucin-producing neoplasms in the skin.- - - - - - - - - - ranking = 0.2keywords = tongue (Clic here for more details about this article) |
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