1/5. Immunohistochemical study of epiretinal proliferative cellular tissue from a patient with sarcoidosis.BACKGROUND: sarcoidosis is a granulomatous disease causing uveitis. Although steroid therapy is usually effective for many patients, some are resistant to this therapy. In such cases, vitrectomy may be chosen as the therapeutic method to treat intraocular inflammation. CASE: A 26-year-old Japanese man was diagnosed as having sarcoidosis by clinical findings and histological examination of bronchoalveolar lavage. observation: One year after diagnosis, vitreous opacity worsened and pars plana vitrectomy (PPV) was performed. Six months later, recurrence of vitreous opacity appeared and severe retinal exudative changes with proliferative vitreoretinopathy developed. One year after the first operation, PPV was repeated and the epiretinal proliferative tissue was removed and examined. CONCLUSIONS: Histologic examination of the specimen showed scattered noncaseating granulomatous inflammation mainly consisting of epithelioid histiocytes and lymphocytes. plasma cells as well as T cells were identified and the predominance of CD8-positive T cells was demonstrated. Taking everything into consideration, a new finding of CD8 predominance in the epiretinal proliferative tissue was demonstrated.- - - - - - - - - - ranking = 1keywords = granulomatous disease (Clic here for more details about this article) |
2/5. Intraosseous sarcoidosis of the jaws mimicking aggressive periodontitis: a case report and literature review.BACKGROUND: sarcoidosis is a relatively common systemic granulomatous disease of unknown etiology. The skeletal system is affected in up to 39% of patients, but intraosseous sarcoidosis affecting the maxilla and mandible is rare. Only 20 cases have been reported previously in the English literature. This paper presents a case of generalized intraosseous sarcoidosis of the jaw bones that mimicked rapidly progressive periodontitis. methods: A 46-year-old male patient presented with loose teeth for assessment of implants. He had been gradually losing his teeth since 1999. His past medical history was significant, with sarcoidosis diagnosed in 1998. A panoramic radiograph showed a bilateral cotton-wool appearance of the mandible. A soft tissue and bone biopsy was performed and sent for histological examination. RESULTS: Microscopic examination of hematoxylin and eosin-stained sections revealed non-caseating granulomatous inflammation consistent with skeletal sarcoidosis. CONCLUSIONS: Intraosseous sarcoidosis of the jaw bones is rare and presents commonly as progressive and rapid alveolar bone loss similar to periodontitis. Therefore, it is important for periodontists to be knowledgeable and able to diagnose this condition, as rapid alveolar bone loss may be the first sign of sarcoidosis.- - - - - - - - - - ranking = 1keywords = granulomatous disease (Clic here for more details about this article) |
3/5. sarcoidosis in chronic granulomatous disease.In addition to increased susceptibility to infections in patients with chronic granulomatous disease (CGD), a higher incidence of sterile inflammatory disorders in these patients has been noted. However, sarcoidosis has not been reported previously in CGD. In this report, we describe two patients who have CGD and a disorder consistent with sarcoidosis on the basis of unequivocal clinical-radiographic presentations, their responses to treatment, and serum angiotensin-converting enzyme levels. serum angiotensin-converting enzyme levels were measured in 26 other patients with CGD to establish an appropriate reference range. A possible relationship between CGD and sarcoidosis is discussed.- - - - - - - - - - ranking = 5keywords = granulomatous disease (Clic here for more details about this article) |
4/5. Can sarcoidosis cause autoamputation of a finger phalanx?sarcoidosis is a multisystemic granulomatous disease. In the case presented, autoamputation of the distal phalanx of a little finger of the left hand was observed. The possibility of autodigital amputation as a result of sarcoidosis is discussed.- - - - - - - - - - ranking = 1keywords = granulomatous disease (Clic here for more details about this article) |
5/5. hydroxychloroquine therapy of diffuse pulmonary sarcoidosis in two Australian male children.sarcoidosis is a chronic granulomatous disease, seen infrequently in children, with the capacity to affect multiple systems. The incidence and prevalence of the disease in children is largely unknown but is dependent on many factors including: age, race and geographical location. There have been very few studies of sarcoidosis in Australian (Aboriginal or white) children. Diffuse pulmonary sarcoidosis is very rare in non-Scandinavian white Caucasian children, yet in the winter of 1992 two Caucasian males, aged 11.1 and 10.5 years were seen at the John Hunter Hospital in Newcastle. Both boys had pulmonary sarcoidosis and after an initial trial of treatment with steroids responded well to hydroxychloroquine therapy.- - - - - - - - - - ranking = 1keywords = granulomatous disease (Clic here for more details about this article) |