1/18. Tenosynovial giant-cell tumor of the cervical spine. Case report.A case of tenosynovial giant-cell tumor affecting the cervical spine is reported. The lesion is seen primarily in the fingers, knee, or ankle, and there are no previous reports of it occurring in the spine. The histological and radiological features of this tumor are discussed along with a brief description of the disease entity.- - - - - - - - - - ranking = 1keywords = giant (Clic here for more details about this article) |
2/18. Primary pulmonary synovial sarcoma confirmed by molecular detection of SYT-SSX1 fusion gene transcripts: a case report and review of the literature.This is a case report of a rare patient with primary pulmonary synovial sarcoma. The patient was a 58-year-old woman who presented with a well-defined giant mass in the right lower field on a chest radiograph. A malignant pulmonary tumor was suspected and consequently a right middle and lower lobectomy was performed. Grossly, the tumor measured 10 x 8 x 7 cm, was whitish-yellow in color and friable with hemorrhage. Histologically, the tumor showed a dense proliferation of spindle cells. In some areas, a herringbone-like pattern with coagulation necrosis of large size was noted. Immunohistochemically, the tumor cells were focally positive for cytokeratin and epithelial membrane antigen (EMA). As these features suggested a monophasic synovial sarcoma, we looked for the presence of SYT-SSX fusion gene transcripts using rna samples from the paraffin-embedded tissue. A reverse transcription-polymerase chain reaction (RT-PCR) amplified a single 118 bp fragment characteristic of the SYT-SSX1 fusion gene transcripts. As no tumor was found at other sites, it was diagnosed as primary pulmonary synovial sarcoma. Molecular testing proved to be very helpful or necessary when monophasic spindle cell synovial sarcoma was recognized in uncommon/unexpected sites. In our review of primary pulmonary synovial sarcomas confirmed by molecular detection of SYT-SSX fusion gene transcripts, the SYT-SSX2 fusion protein expression correlates with poorer prognosis. This is in contrast to the association between the SYT-SSX1 fusion protein expression and poorer prognosis in soft tissue synovial sarcomas.- - - - - - - - - - ranking = 0.2keywords = giant (Clic here for more details about this article) |
3/18. The acute carpal tunnel syndrome: nine case reports.Nine cases of acute carpal tunnel syndrome are reported. Etiologies include: bleeding secondary to chronic lymphatic leukemia; colles' fracture of the wrist (2 cases); Epiphyseal fracture (Salter II) of the distal radius; Bleeding secondary to giant cell tumor of the tendon sheath; Unstable distal radio-ulnar joint; Displaced intra-articular fracture of the distal radius; Rheumatoid synovitis and vasculitis; Trans-scaphoid, perilunar fracture dislocation of the wrist. Early recognition of median nerve compression in the carpal tunnel is vital. The signs of median nerve compression should be looked for in all cases of wrist trauma. In our opinion, immediate surgical decompression is frequently indicated.- - - - - - - - - - ranking = 0.2keywords = giant (Clic here for more details about this article) |
4/18. Pigmented villonodular synovitis of the temporomandibular joint. Case Report.Pigmented villonodular synovitis is a lesion containing giant cells and, because of its tendency to recur, it is easily confused with a malignant process. However, careful review of the histological material will reveal that there is no nuclear atypism or mitotic figures. Also, there have been no reports attributing metastases or death to thid disease. The clinical course of our case was definitely benign.- - - - - - - - - - ranking = 0.2keywords = giant (Clic here for more details about this article) |
5/18. Solitary multinodular giant cell tumor of tendon sheath.We present a 74 year old man with a solitary multinodular tumor of the right thumb and an adenocarcinoma of the prostate. Histologic examination of the hand tumor revealed a giant cell tumor of tendon sheath.- - - - - - - - - - ranking = 1keywords = giant (Clic here for more details about this article) |
6/18. MR evaluation of giant cell tumors of the tendon sheath.Giant cell tumor of the tendon sheath (GCTTS) is a benign condition that involves the synovium of the tendon sheaths. Histologically, GCTTS is similar to pigmented villonodular synovitis. The MRI findings in two cases of GCTTS are reported. In both cases, predominantly low signal is seen on T1-weighted, proton density weighted, and T2-weighted images. This information may be useful in distinguishing GCTTS from other mass lesions involving the tendon sheaths.- - - - - - - - - - ranking = 0.8keywords = giant (Clic here for more details about this article) |
7/18. Malignant giant cell tumor of synovium and locally destructive pigmented villonodular synovitis: ultrastructural and immunohistochemical study and review of the literature.The first reported case of an intraarticular malignant giant cell tumor of synovium studied with electron microscopic and immunohistochemical examination is presented, together with a case of diffuse intraarticular pigmented villonodular synovitis with extensive bone destruction. The malignant case was dominated by uniform cells positive for histiocytic markers, the fine structure showing a gradual change from cells dominated by organelles serving a secretory function to cells with phagocytic activity. The reported cases of giant cell tumor of the tendon sheath indicate that the pertinent histologic changes regarding malignancy are an increase in cell polymorphism and in the number of mitoses, and a decrease in the number of multinucleated giant cells.- - - - - - - - - - ranking = 1.4keywords = giant (Clic here for more details about this article) |
8/18. Giant cell tumor of tendon sheath.The giant cell tumor of tendon sheath (localized nodular tenosynovitis) is the second most common tumor involving the hand but is only rarely reported in the dermatologic literature. A case of giant cell tumor and a review of the clinical and pathologic records of 111 patients are discussed.- - - - - - - - - - ranking = 0.4keywords = giant (Clic here for more details about this article) |
9/18. Oncogenic hypophosphatemic osteomalacia associated with a giant cell tumour of a tendon sheath.We report a case of oncogenic hypophosphatemic osteomalacia, a rare form of osteomalacia, secondary to a diffuse giant cell tumour of tendon sheath. Possible pathogenic factors are discussed in the light of previously described clinical and experimental observations.- - - - - - - - - - ranking = 1keywords = giant (Clic here for more details about this article) |
10/18. Malignant giant cell tumor of tendon sheath. Report of a case.In a patient with pigmented villonodular synovitis of the right knee joint, there occurred a malignant giant cell tumor of tendon sheath. There was clinical evidence of metastasis after the second local recurrence and the recurrent tumors were studied enzyme cytochemically and electron microscopically. Ultrastructurally, the malignant tumor consisted of three principal cell types; histiocyte-like cells, fibroblast-like cells, and intermediate cells, with unique attendance of myofibroblasts. This may be the first report of the presence of myofibroblasts in malignant giant cell tumor of tendon sheath. Enzyme cytochemistry revealed various functional properties of histiocytes.- - - - - - - - - - ranking = 1.2keywords = giant (Clic here for more details about this article) |
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