1/20. Nuchal fibroma associated with scleredema, diabetes mellitus and organic solvent exposure.A case of scleredema diabeticorum of Buschke associated with nuchal fibroma and organic solvent exposure is reported. The patient presented with a neck mass causing discomfort and restriction of movement. Histological examination showed this to be a nuchal fibroma. Additionally, there was widespread induration of the skin of his trunk which was asymptomatic. A biopsy showed features of scleredema. This is the first reported association of these two conditions, both of which show increased and thickened collagen bundles without significant fibroblast proliferation. They differ by the occurrence of mucin in scleredema, although this is not always demonstrable, particularly in late lesions. The possibility that nuchal fibroma is an end stage, localized form of scleredema is canvassed. The patient's medical history included insulin-dependent diabetes mellitus with complications of retinal vessel thrombosis and peripheral neuropathy. The patient also had significant past exposure to a wide variety of chemicals, including organic solvents.- - - - - - - - - - ranking = 1keywords = diabetes mellitus, mellitus, diabetes, insulin-dependent (Clic here for more details about this article) |
2/20. Beneficial effect of aggressive low-density lipoprotein apheresis in a familial hypercholesterolemic patient with severe diabetic scleredema.We present a 59-year-old woman with severe diabetic scleredema (DS) associated with heterozygous familial hypercholesterolemia (FH). She had been treated with drugs to lower blood glucose, with insulin for diabetes mellitus (DM), and with low-density lipoprotein (LDL) apheresis therapy monthly or every 2 weeks in addition to drugs to lower serum lipids for FH. However, her scleredema had not improved. After we had tried weekly LDL apheresis therapy for a period of 3 years to treat her hyperlipidemia, the levels of her serum lipids were reduced to normal ranges, and scleredema in her nape improved. We also demonstrated the histopathological improvement in dermis of her cervical skin. We conclude that weekly LDL apheresis therapy is effective for diabetic scleredema that is resistant to conventional treatments.- - - - - - - - - - ranking = 0.19864378325832keywords = diabetes mellitus, mellitus, diabetes (Clic here for more details about this article) |
3/20. Ultrastructural abnormalities in the skin nerves of a patient with scleredema adultorum (Buschke) and diabetes mellitus.In an electron-microscopic study of the skin of a patient with scleredema adultorum (Buschke) and diabetes mellitus, the unmyelinated nerve fibres showed accumulations of glycogen. On morphological grounds, these accumulations appeared to be located in the axons.- - - - - - - - - - ranking = 0.99321891629159keywords = diabetes mellitus, mellitus, diabetes (Clic here for more details about this article) |
4/20. Scleredema diabeticorum--a case report.A 41 year male, diabetic on treatment presented with persistent erythema and. "taut" skin over neck and back since 1 year. The lesions showed symmetric and gradual progression. There was no history of prior sore throat. On examination effected skin was erythematous, woody hard and unpinchable. Scleredema diabeticorum (diutinum), although sharing clinical and historical features with scleredema adultorum has no prodromal infection, is more extensive and affected individuals are characteristically obese, middle aged diabetics who often have accompanying microangiopathies and macroangiopathies. Recognition of scleredema by the physician has prognostic and therapeutic implications in the management of the coexisting diabetes.- - - - - - - - - - ranking = 0.028649280166266keywords = diabetes (Clic here for more details about this article) |
5/20. Scleroderma.A 72-year-old man with diabetes-associated scleredema is presented. The patient had a long history of diabetes mellitus that had been difficult to control with complications of retinopathy, nephropathy, and arteriosclerosis leading to myocardial infarcts and stroke. The scleredema has remained stable with 4 months of topical clobetasol ointment twice daily and biweekly physical therapy. Diseases associated with scleredema and therapeutic options are summarized.- - - - - - - - - - ranking = 0.22729306342458keywords = diabetes mellitus, mellitus, diabetes (Clic here for more details about this article) |
6/20. Scleredema of Buschke: remission with factor xiii treatment.We describe the case of a 55-year-old man with scleredema of Buschke of the torso complicated by insulin-dependent diabetes mellitus. Due to (i) the patient's poor general health status, (ii) the similarity between scleroderma and scleredema of Buschke, and (iii) the well known efficacy of factor xiii infusions in scleroderma, we attempted an intravenous treatment with factor xiii. This therapy resulted in marked increase of movements and in softening of the skin, together with ultrasonographic and histopathological improvements. In conclusion, to the best of our knowledge, this is the first case in which factor xiii has been successfully used for the treatment of scleredema of Buschke.- - - - - - - - - - ranking = 0.20542486696673keywords = diabetes mellitus, mellitus, diabetes, insulin-dependent (Clic here for more details about this article) |
7/20. acanthosis nigricans in a plaque of scleredema on the back of a diabetic patient: a case report.acanthosis nigricans (AN) and scleredema are two skin conditions that have been reported in association with diabetes mellitus. Few cases associating scleredema and AN have been reported. A literature search did not reveal any reports of diabetic patients developing AN on top of a scleredema plaque. Here we report a patient with diabetes mellitus who developed AN within the same indurated scleredema plaque.- - - - - - - - - - ranking = 0.39728756651664keywords = diabetes mellitus, mellitus, diabetes (Clic here for more details about this article) |
8/20. scleredema adultorum of Buschke presenting as periorbital edema: a diagnostic challenge.scleredema adultorum is a rare sclerotic disorder characterized by diffuse swelling and nonpitting induration of the skin. Its occurrence has been documented in association with infections, diabetes mellitus, paraproteinemia, multiple myeloma, and monoclonal gammopathy. We report an unusual case of a 48-year-old man with an asymptomatic bilateral eyelid edema of sudden onset. During a period of 6 months, the condition slowly progressed to extensive nonpitting edematous swelling restricted to the periorbital sites. The presumptive diagnosis of scleredema adultorum was confirmed by the presence of typical histologic findings. This case is unique in that the periorbital swelling remained as the sole clinical manifestation of scleredema during the 5-year follow-up and was complicated with partial vision blockage.- - - - - - - - - - ranking = 0.19864378325832keywords = diabetes mellitus, mellitus, diabetes (Clic here for more details about this article) |
9/20. Scleredema and diabetic sclerodactyly.A 40-year-old man presented with hardening of the skin of his hands and upper back, which had slowly worsened with time. His medical history included insulin-dependent diabetes mellitus since childhood. Histopathologic features of a biopsy specimen from the skin of his back showed a thick reticular dermis with collagen bundles in a haphazard array, which were separated by increased deposits of connective-tissue mucin. Scleredema and diabetic sclerodactyly are both well recognized skin findings that may occur in patients with diabetes mellitus. It is important to differentiate this condition from scleroderma. Treatment is difficult, and therefore many modalities have been used. This patient has improved with aminobenzoate, colchicine, and DMSO gel.- - - - - - - - - - ranking = 0.40406865022504keywords = diabetes mellitus, mellitus, diabetes, insulin-dependent (Clic here for more details about this article) |
10/20. An unusual finding in scleredema.Scleredema of Buschke is a rare disorder in which areas of induration appear in the skin, commonly after a remote infection and sometimes with diabetes and para-proteinemias. We report an unusual finding in an adult patient of long standing classical scleredema who developed chronic clustered papules/pseudovesicular lesions with koebnerization after a bacterial infection of the upper back.- - - - - - - - - - ranking = 0.028649280166266keywords = diabetes (Clic here for more details about this article) |
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