1/3. Molecular evidence of male-to-female sexual transmission of hepatitis c virus after vaginal and anal intercourse.hepatitis c virus (HCV) was transmitted from a chronic carrier to his female partner during unprotected anal and vaginal intercourse. Based on HVR1 and phylogenetic tree analysis, the couple had closely related isolates. These findings confirm sexual transmission of HCV without other risk factors.- - - - - - - - - - ranking = 1keywords = tree (Clic here for more details about this article) |
2/3. Sexual transmission of hepatitis c virus from a patient with chronic disease to his sex partner after removal of an intrauterine device.BACKGROUND: Approximately 40% of patients infected with hepatitis c virus (HCV) have no history of blood transfusion or other high-risk practice. Other causes should be considered. GOAL: The goal was to describe sexual transmission of HCV from a chronic carrier to his female partner during unprotected vaginal intercourse after removal of an intrauterine device. STUDY DESIGN: A heterosexual woman who was a regular blood donor acquired acute HCV infection from her sex partner, who was chronically infected. The study included an interview and phylogenetic analysis of sequences of virus obtained from the couple. RESULTS: risk factors other than vaginal sexual relations with her partner were ruled out. Phylogenetic analysis showed that sequences from the couple clustered together in all trees generated, in comparison with local and GenBank controls. CONCLUSION: The temporal relationship between removal of the intrauterine device and the acute hepatitis suggests that vaginal mucosal damage might have favored transmission of HCV. Barrier precautions should be suggested whenever damage of the vaginal tract has occurred.- - - - - - - - - - ranking = 1keywords = tree (Clic here for more details about this article) |
3/3. Condyloma acuminata: a fatal disease?Condyloma acuminata is a virally mediated epithelial overgrowth caused by the human papilloma virus. Its simplest form is the common wart, which may occur almost anywhere on the body surface. Its papillary lesion forms are commonly seen in the genital, perineal, and anal areas, though it also infects the conjunctiva, nose, mouth, larynx, and tracheo-bronchial tree. Malignant degeneration may occur in any of these areas. diagnosis is established by clinical impression and biopsy. immunoassay methods exist but are simply indicative of the presence of infection and are not useful in predicting the course of the disease. Many treatment modalities exist and all work well for minor lesions. For large lesions such as the giant condyloma acuminata, also known as the Buschke-Lowenstein lesion, only radical surgical extirpation is considered to be appropriate treatment. This case report, as well as others referenced in this study, documents the extreme complexity of management of many of these lesions and the fatal outcome of this disease process in a significant number of cases.- - - - - - - - - - ranking = 1keywords = tree (Clic here for more details about this article) |