1/18. Accelerated silicosis with mixed-dust pneumoconiosis in a hard-metal grinder.We describe a fatal case of accelerated silicosis with a component of mixed-dust pneumoconiosis in a young hard-metal grinder that we believe is the first case of its kind in israel and one of the rare cases reported worldwide. The patient's diagnosis was based on typical features: restrictive lung function, abnormal chest roentgenogram suggesting lung fibrosis, a history of exposure to silica and hard metals, bronchoalveolar lavage (BAL) fluid findings, and mineralogical studies. BAL cells showed an abundance of giant multinucleated macrophages. The CD4/CD8 ratio of T lymphocytes was 1.1, with a high percentage of CD8 and CD8/38 positive cells (37% suppressor/cytotoxic and 12% cytotoxic T lymphocytes, respectively). mRNA transcripts isolated from BAL cells were positive for interleukin-1 (IL-1) and transforming growth factor (TGF) Il-5, IL-2, and IL-10 but not for IL-6, IL-4, and interferon. Polarizing light microscopic studies of BAL and induced sputum cells showed polarizing particles, which are typical for silica. Mineralogical studies of electron microscopy performed on BAL fluid and on dust collected at the patient's workstation revealed silica particles as well as aluminum-titanium and other particles. The latter might have contributed to the patient's lung disease.- - - - - - - - - - ranking = 1keywords = alveolar (Clic here for more details about this article) |
2/18. Silicoproteinosis: high-resolution CT and histologic findings.The high-resolution CT findings of silicoproteinosis consist of numerous bilateral centrilobular nodular opacities, focal ground glass opacities, and patchy areas of consolidation. These findings reflect the presence of intra-alveolar accumulation of proteinaceous material.- - - - - - - - - - ranking = 1keywords = alveolar (Clic here for more details about this article) |
3/18. Silicoproteinosis of the lung in a 49-year-old man.We report a rare case of silicosis, histologically corresponding to silicoproteinosis and tuberculosis, in a man working consecutively as a miner, blacksmith and founder. A microscopic study revealed deposits in alveoli, in which immunohistochemistry did not reveal surfactant (SP-A), that was present in the alveolar fluid in alveolar lipoproteinosis.- - - - - - - - - - ranking = 2keywords = alveolar (Clic here for more details about this article) |
4/18. Silicotic alveolar proteinosis with bilateral spontaneous pneumothorax.Bilateral spontaneous pneumothorax due to silicotic alveolar proteinosis is reported because of its rarity.- - - - - - - - - - ranking = 5keywords = alveolar (Clic here for more details about this article) |
5/18. Case series: use of induced sputum in the evaluation of occupational lung diseases.The authors recently reported that analysis of induced sputum may reveal the status of hazardous dust exposure (e.g., silica, hard metals) as effectively as does bronchoalveolar lavage. In the current study, the authors describe how induced sputum can assist in the evaluation and diagnosis of suspected occupational lung diseases. The 3 patients who underwent induced sputum testing included a miner with silicosis, a dental technician with berylliosis, and a teacher who suffered from undefined interstitial fibrosis and in whom induced sputum analysis revealed the presence of a high burden of calcium sulfate and silica. The data reported indicate that induced sputum--a known safe and simple procedure--can serve as a useful tool in the evaluation of patients with suspected occupational lung diseases.- - - - - - - - - - ranking = 1keywords = alveolar (Clic here for more details about this article) |
6/18. silicosis in dental laboratory technicians--five states, 1994-2000.silicosis is a debilitating, sometimes fatal, yet preventable occupational lung disease caused by inhaling respirable crystalline silica dust. Although crystalline silica exposure and silicosis have been associated historically with work in mining, quarrying, sandblasting, masonry, founding, and ceramics, certain materials and processes used in dental laboratories also place technicians at risk for silicosis. During 1994--2000, occupational disease surveillance programs in five states identified nine confirmed cases of silicosis among persons who worked in dental laboratories; four persons resided in michigan, two in new jersey, and one each in massachusetts, new york, and ohio. This report describes three of the cases and underscores the need for employers of dental laboratory technicians to ensure appropriate control of worker exposure to crystalline silica.- - - - - - - - - - ranking = 0.000680744538741keywords = process (Clic here for more details about this article) |
7/18. silicosis in ceramic-industry workers with particular reference to the diagnostic value of bronchoalveolar lavage.We could identify, via bronchoalveolar lavage, crystals in the lavage fluid and in the alveolar macrophages. Thus, BAL could be another method for diagnosing silicosis patients.- - - - - - - - - - ranking = 6keywords = alveolar (Clic here for more details about this article) |
8/18. silicosis among gemstone workers in south africa: tiger's-eye pneumoconiosis.Six cases of silicosis in workers involved in the processing of semiprecious gem stones have been seen in our clinic since 1976. They had been employed as stone sculptors in lapidaries where they processed tiger's-eye, rose quartz, amethyst, quartz crystal, and a variety of other locally occurring semiprecious stones. In five of the cases, exposure was in small and poorly regulated lapidaries without specific dust control measures. The sixth was detected during the course of a health and hygiene survey (including dust sampling) that was conducted in one of two lapidaries still operating in our area. Progressive massive fibrosis (PMF) or accelerated silicosis was noted in four of the six cases, three of whom had progression of their disease after cessation of exposure. With the development of PMF, the initial restrictive pulmonary function abnormalities were followed by steadily worsening airflow obstruction. Lung biopsies confirmed silicosis in three cases. tuberculosis was confirmed in two cases and suspected and treated in a third. Workmen's Compensation was awarded in five cases. The survey confirmed that in semiprecious gem stone processing, the risk of silicosis appears to be confined to stone sculptors. Tried and proven techniques of general and local exhaust ventilation combined with water or oil to control dust at source were capable of effectively reducing dust emission to acceptable levels.- - - - - - - - - - ranking = 0.002042233616223keywords = process (Clic here for more details about this article) |
9/18. Acute silicoproteinosis.A case of alveolar lipoproteinosis associated with silicosis is reported. A 58-year-old man had been exposed to silica for seven years and died three years after the onset of symptoms. light microscopy of biopsy and necropsy material showed small silicotic nodules, silica particles, and alveolar lipoproteinosis, and ultrastructural studies were performed to define changes in alveolar epithelium and macrophages. The case provides a further example of alveolar lipoproteinosis developing as a response of the lung to injury by an external agent.- - - - - - - - - - ranking = 4keywords = alveolar (Clic here for more details about this article) |
10/18. silicosis in diatomaceous earth factory workers in sweden.Kieselguhr is a greyish-white powder which is made by heating lake ooze containing diatom skeletons to a temperature of about 1000 degrees C. It contains quartz, cristobalite and tridymite. Working with kieselguhr can induce silicosis. In sweden six cases of silicosis caused by exposure to kieselguhr have been reported to the Worker's Protection Board. The time of exposure was relatively short. New cases have not appeared in the last 20 years. It seems, nevertheless, important to document this unusual form of silicosis, as diatomaceous earth is readily available and the manufacturing process is simple. Demand for kieselguhr has increased and new factories are to be established which may result in new cases of silicosis.- - - - - - - - - - ranking = 0.000680744538741keywords = process (Clic here for more details about this article) |
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