1/9. Erosive pustular dermatosis of the scalp after skin grafting.Erosive pustular dermatosis of the scalp is a rare condition of unknown etiology that usually occurs in the elderly and is characterized by pustules that appear on the scalp leading to scarring alopecia. The histopathology is not specific. Its onset has been related with previous trauma on the scalp. Only three cases after skin grafting have been reported. We describe a case of erosive pustular dermatosis of the scalp appearing on a split-thickness skin graft placed after excision of a basal cell carcinoma.- - - - - - - - - - ranking = 1keywords = carcinoma (Clic here for more details about this article) |
2/9. adult-onset facial colloid milium successfully treated with the long-pulsed Er:YAG laser.BACKGROUND: adult colloid milium is a rare cutaneous deposition disorder that frequently involves areas of chronic sun exposure, especially the face and dorsal hands. Attempts to remove these lesions are generally unsuccessful, but dermabrasion has been reported to be effective. OBJECTIVE: To present an effective therapeutic alternative to dermabrasion for facial colloid milium. methods: A 41-year-old man with extensive facial colloid milium underwent full-face resurfacing with a long-pulsed Er:YAG laser (9.8 J/cm2, 5 mm spot, 10-msec pulse duration). Additional passes were performed over the areas of dense colloid milium to achieve approximately 80% ablation of lesions.results. At the 7-month follow-up there was no scarring, textural changes, dyspigmentation, or clinical evidence of recurrence. CONCLUSION: Long-pulsed Er:YAG laser should be considered an effective alternative to dermabrasion for facial colloid milium.- - - - - - - - - - ranking = 6148.1148262466keywords = colloid (Clic here for more details about this article) |
3/9. Colloid milium of the upper eyelid margins: a rare presentation.AIM: To report a rare presentation of colloid milium occurring only on the upper eyelid margins. DESIGN: Interventional case report. methods: (1) Slit-lamp examination of eyelids and eyes and clinical examination including the face and a general physical examination; (2) photography of the lesions on the lids; and (3) excision biopsy and histopathologic examination. MAIN OUTCOME MEASURES: Histologic examination confirmed the clinical diagnosis. RESULTS: Clinical examination and histopathologic findings revealed the cysts to be colloid milium. CONCLUSIONS: Colloid milium can involve upper eyelids in isolation, sparing the lower eyelids and facial skin. Such rare presentations should be kept in mind while examining similar lesions.- - - - - - - - - - ranking = 1366.2477391659keywords = colloid (Clic here for more details about this article) |
4/9. Systemic lupus erythematosus with unusual maculopapular and erosive cutaneous lesions.In 2002, a 38-year-old woman was referred to the department of dermatological sciences for the evaluation of erythematous-infiltrated lesions with prominent purpuric and erosive components distributed on her face, upper chest, and extensor surfaces of the limbs, which developed over a 3-month period. In 1997 the patient suffered from polyarthralgia (proximal interphalangeal,knee, wrist, and metacarpophalangeal joints) associated with morning stiffness. In 1999 she was admitted to a psychiatric unit for depression with episodes of lipothymia. In the same year, since she developed diffuse and persistent urticarial manifestations with angioedema and livedo reticularis of the limbs in association with anticardiolipin antibodies, vasculitis was proposed. Upon examination, erythematous-infiltrated and erosive lesions in association with serohemorrhagic crusts were present on the face,neck, chest, upper trunk, and extensor surfaces of the upper limbs and thighs (Figures 1-3). Telangiectasias were especially evident on the cheeks, where prominent edema conferred her face a moon-like appearance (Figure 1). Laboratory investigations disclosed microcytic anemia, elevated erythrocyte sedimentation rate, proteinuria (30 mg/dL), positive antinuclear antibodies (1:80) with diffuse fluorescence pattern, lowered complement levels (C3: 31 mg/dL, C4: 3 mg/dL), circulating immunocomplexes binding Clq, and high titers of anti-TSH receptor antibodies. Indirect immunofluorescence was negative for the detection of anti-basement membrane zone antibodies. Histological examination of the lesional skin of the shoulder documented epidermal atrophy, marked vacuolar degeneration of the basal cell layer, colloid bodies, and a perivascular lymphohistiocytic infiltration of the upper and deep dermis (Figure 4). Direct immunofluorescence performed on affected skin showed junctional granular deposition of IgG, C3,and Clq in association with perivascular C3 and Clq deposits in the upper dermis; direct immunofluorescence on sun-protected,non-lesional skin showed similar immunological deposition both at the basement membrane zone and in the perivascular dermis.Based upon the clinical, histologic, and immunopathologic findings, we proposed the diagnosis of systemic lupus erythematosus with maculopapular and erosive skin lesions. The patient was treated with methylprednisolone IV (pulse therapy, 250 mg) tapered over 10 days and later continued p.o. After a few weeks, significant improvement of cutaneous manifestations was noted.- - - - - - - - - - ranking = 683.12386958295keywords = colloid (Clic here for more details about this article) |
5/9. Elastosis colloidalis conglomerata (adult colloid milium, paracolloid of the skin): a maximal manifestation of actinic elastosis?We report the case of a 50-year-old woman with multiple soft papules in the perioral region resistant to local corticosteroid and antibiotic therapies. histology revealed elastosis colloidalis conglomerata. There were no hints for a deposition disease. The patient was treated with local retinoids. We report on the therapeutic outcome.- - - - - - - - - - ranking = 8880.6103045784keywords = colloid (Clic here for more details about this article) |
6/9. Self limited dermal invasion of keratinocytes in maculopapular eruptions after systemic chemotherapy.Benign, multifocal, and transient (spontaneously disappearing within one month) stromal invasions of atypical basal keratinocytes were found in light and electron microscopic examination of maculopapular eruptions which developed after receiving an 8 day cycle of doxorubicin, 5-fluorouracil (5-FU), and cyclophosphamide (Cy) in a 63-year-old woman. She had had a modified radical mastectomy to remove a carcinoma of her right breast.- - - - - - - - - - ranking = 1keywords = carcinoma (Clic here for more details about this article) |
7/9. stroke-induced purpura in lesions of colloid milium.We describe three patients with colloid milium whose lesions showed purpura upon stroking. Two of these patients had juvenile colloid milium and the third had adult colloid milium. Ultramicroscopic examination of purpuric colloid papules showed that the dermal blood vessel walls were infiltrated by colloid material. Traumatic purpura occurring in colloid milium may be analogous to that occurring in systemic amyloidosis. We suggest that the infiltrating colloid material decreases the elasticity of dermal blood vessel walls, accounting for the purpura following minor trauma.- - - - - - - - - - ranking = 7514.3625654125keywords = colloid (Clic here for more details about this article) |
8/9. Widespread pruritic plaques in a patient with subacute cutaneous lupus erythematosus and hypocomplementemia: response to dapsone therapy.We describe a patient with subacute cutaneous lupus erythematosus, widespread pruritic papulosquamous plaques, and hypocomplementemia. skin biopsy specimens revealed liquefaction degeneration and colloid bodies and dyskeratotic cells in basal and suprabasal layers. An immunofluorescence study revealed deposits of IgG, IgM, and C3 at the dermalepidermal junction in a bandlike pattern, and particulate IgG deposition in the basal and suprabasal layers. Treatment with prednisolone (15 mg/day), chloroquine phosphate (200 mg/ day), cyclosporine (5 mg/kg daily), and gold (10 mg/day) failed to reduce pruritic plaque formation, and pulse methylprednisolone therapy led to only a transient remission. Clinical exacerbations correlated with a decrease in complement levels. The disease was successfully controlled with dapsone (75 mg/day) and prednisolone (25 mg/day).- - - - - - - - - - ranking = 683.12386958295keywords = colloid (Clic here for more details about this article) |
9/9. Heterogeneity of human papillomavirus dna in a patient with Bowenoid papulosis that progressed to squamous cell carcinoma.Bowenoid papulosis (BP) of the genitalia, characterized by the histological findings of a squamous cell carcinoma, follows a largely benign clinical course. The detection of oncogenic human papilloma viruses (HPV) from BP points to an aetiological role of these viral infections. A 47-year-old man with multiple genital skin lesions was seen over a 10-year period with the diagnosis of BP. Recently, he attended again with a recurrent genital tumour that was diagnosed as squamous cell carcinoma. His genital lesions progressed and became polymorphic in appearance, from a wart-like tumour to a reddish invasive plaque. To screen for the presence of different HPV sequences from different skin lesions and to correlate each HPV type with distinct clinical manifestations, polymerase chain reaction and single-strand conformational polymorphism (PCR-SSCP) were performed. PCR-SSCP revealed the presence of several types of HPV from different genital lesions. Sequencing results disclosed that he had a mixed infection of HPV6b, HPV16, HPV18 and HPV33, respectively. Interestingly, the clinical findings were fairly well correlated with the oncogenic potential of HPV found from each lesion.- - - - - - - - - - ranking = 6keywords = carcinoma (Clic here for more details about this article) |