1/4. Expression of Th1 and Th2 cytokine mRNAs in freshly isolated peripheral blood mononuclear cells of a patient with cutaneous paragonimiasis.Using semiquantitative reverse transcriptase polymerase chain reaction, we examined the levels of various cytokine mRNAs of freshly isolated peripheral blood mononuclear cells (PBMCs) from a cutaneous paragonimiasis patient in the course of successful treatment with praziquantel administration. The pre-treatment levels of Th2 cytokines such as interleukin (IL)-4, IL-5, IL-10 and IL-13 mRNAs in PBMCs of the patient were much higher than those of healthy controls. The levels of IL-4, IL-5 and IL-13 mRNAs slightly elevated on day 2 of the treatment and then declined to the control levels on day 25. The IL-10 mRNA level rapidly decreased after the chemotherapy. In contrast, the mRNA levels of interferon (IFN)-gamma, a Th1 cytokine, remained in the control levels during the course. Peripheral eosinophil counts and levels of total IgE and eosinophil cationic protein in the sera correlated well with the levels of these Th2 cytokine mRNAs. These results suggested the major role of Th2 cytokines in clinical manifestation of human helminthic infection.- - - - - - - - - - ranking = 1keywords = paragonimiasis (Clic here for more details about this article) |
2/4. A case of cutaneous paragonimiasis with pleural effusion.BACKGROUND: paragonimiasis is an infectious disease caused by paragonimus, which persists in the lung of mammals. infection in the skin is very rare. RESULTS: A subcutaneous tumor with itching developed on the right lateroabdominal region of a 55-year-old man 10 days after eating fresh-water crab. It was surgically excised 2 months later. Examination of a specimen of the surgically excised tumor revealed an abscess containing many eosinophils. parasites or other infectious organisms were not found in sections. The blood eosinophil count of the patient was elevated, and P. westermani-specific immunoglobulin g (IgG) antibody titer was strongly detected in the serum. The tumor was diagnosed as cutaneous paragonimiasis caused by P. westermani. Three months after eating the crab, a chest x-ray film showed a pleural effusion. P. westermani-specific IgG antibody was also detected in the pleural fluid. The patient was given 75 mg/kg/day of praziquantel for 3 days. The pleural effusion gradually disappeared after the medication. CONCLUSIONS: This patient had cutaneous paragonimiasis with a skin tumor that was diagnosed prior to the expression of a pleural effusion.- - - - - - - - - - ranking = 1.2keywords = paragonimiasis (Clic here for more details about this article) |
3/4. Cutaneous paragonimiasis in man in honduras.A worm found in histopathologic sections of the skin of a 31-year-old man in honduras was identified as paragonimus sp. The worm was immature, and specific identification was not possible. This is the second human case of paragonimiasis in honduras.- - - - - - - - - - ranking = 1keywords = paragonimiasis (Clic here for more details about this article) |
4/4. Soluble CD23 and IL-5 levels in the serum and culture supernatants of peripheral blood mononuclear cells in a girl with cutaneous paragonimiasis: case report.We examined the levels of soluble CD23 (sCD23) and IL-5 in the serum and culture supernatants of the peripheral blood mononuclear cells of a 9-year-old girl with cutaneous paragonimiasis without respiratory symptoms. Before treatment, levels of both sCD23 and IL-5 in her serum and culture supernatants were elevated compared with those of controls. After successful treatment with praziquantel, sCD23 and IL-5 levels rapidly reduced to normal levels. These results indicate that sCD23 and IL-5 are involved in the immune-mediated pathological responses seen in paragonimiasis.- - - - - - - - - - ranking = 1.2keywords = paragonimiasis (Clic here for more details about this article) |