1/23. Identification of connexins in human oral mucosa and therapeutic effect of irsogladine maleate on aphthous stomatitis.We identified connexins 26 and 32 in human oral mucosa. The presence of the connexins indicates the presence of gap junctions in this tissue. However, immunofluorescence study found no significant differences in the expression of the connexins between patients with aphthons stomatitis and controls. Irsogladine maleate, which reinforces gap junctional intercellular communication in vitro, was effective for the treatment of transient and relapsing aphthous stomatitis, as well as symptomatic and drug-induced aphthous stomatitis. It was also useful for prevention of episodes of relapsing aphthous stomatitis, with daily administration preverting recurrence of stomatitis for more than 4 years one patient. These findings suggest that irsogladine maleate accelerates the wound healing process in oral mucosa by reinforcing gap junctional intercellular communication among oral mucosal cells; and that it is useful for the treatment and prevention of aphthous stomatitis.- - - - - - - - - - ranking = 1keywords = mucosa (Clic here for more details about this article) |
2/23. The advantages of MRI and MRA for diagnosing Behcet's disease and internal jugular vein thrombosis.Behcet's disease is a multisystem disorder characterized by recurrent aphtous ulcers of mucosal membranes, skin lesions, and vasculitis. The prevalence of vascular involvement is about 25% and this is the leading cause of death in Behcet's disease. Jugular vein involvement is an unusual manifestation of Behcet's disease. Medical insertion of needles into veins or arteries can induce thrombosis or aneurysms. Thus, diagnostic studies or therapy can aggravate the disease and even be fatal. We report a patient with Behcet's disease and rare internal jugular vein thrombosis. We also demonstrate the ability of noninvasive magnetic resonance imaging and magnetic resonance angiography to aid in the diagnosis and evaluation of vascular involvement in Behcet's disease, without risking iatrogenic complications.- - - - - - - - - - ranking = 0.14436767498271keywords = mucosa, membrane (Clic here for more details about this article) |
3/23. Oral mucosal non-Hodgkin's lymphoma--a dangerous mimic.Reports of T-cell lymphomas in the oral cavity are rare. Most have presented as a persisting ulcerated swelling. This paper reports two men, one of whom presented with a short history of increasing facial swelling and pain apparently related to a lower premolar tooth, and the other who had recurrent oral ulceration in several sites over a period of years. These types of cases are likely to present initially to general dental practitioners.- - - - - - - - - - ranking = 0.57142857142857keywords = mucosa (Clic here for more details about this article) |
4/23. Oral ulceration: a new and unusual complication.Oral ulceration is a common oral mucosal disorder arising from a range of aetiologies but, apart from being associated with discomfort or pain, rarely results in complications apart from occasional scarring. This paper reports two patients with a history of minor aphthae who developed ulceration with increasingly severe pain, related to the onset of osteitis, and who then developed sequestra.- - - - - - - - - - ranking = 0.14285714285714keywords = mucosa (Clic here for more details about this article) |
5/23. Oral mucosal herpes simplex ulceration in an hiv-seropositive man.herpes simplex virus (HSV) is a frequent cause of oral mucosal ulceration in hiv-seropositive individuals. The case reported here illustrates the clinical presentation, diagnosis, and management of oral ulceration due to HSV.- - - - - - - - - - ranking = 0.71428571428571keywords = mucosa (Clic here for more details about this article) |
6/23. Idiopathic granulomatous gastritis with multiple aphthoid ulcers.A 47-year-old woman had idiopathic granulomatous gastritis characterized by serpiginous aphthoid ulcer with satellite aphthous ulcers at the antrum to angulus with noncaseating epithelioid granulomas including giant cells in the gastric mucosa. No definite etiologic factors could be detected; systemic sarcoidosis, Crohn's disease, infections (tuberculosis, syphilis and fungus), neoplasm, and foreign body reaction were excluded by additional investigations. However, the patient was found to be infected with H. pylori. Despite the success of H. pylori-eradication, the granulomatous lesion took a long time to heal for at least 17 months or more. The relation between granulomatous gastritis and H. pylori was discussed. There was no apparent evidence of granuloma in the other organs during clinical and follow-up studies for over three years.- - - - - - - - - - ranking = 0.14285714285714keywords = mucosa (Clic here for more details about this article) |
7/23. The myelodysplastic syndromes. Case report and review.The myelodysplastic syndromes are a heterogenous group of hematologic disorders of myeloid progenitor cells. oral manifestations may be among the first signs and often reflect degrees of neutropenia or neutrophil dysfunction. A patient with persistent herpes labialis and severe oral mucosal ulceration in myelodysplastic syndrome is reported. The features of myelodysplasia are reviewed and their oral manifestations and significance to dental management outlined.- - - - - - - - - - ranking = 0.14285714285714keywords = mucosa (Clic here for more details about this article) |
8/23. Aphthous ulcer--a treatment complication. Report of a case.Multiple theories of the cause and treatment of aphthous ulcers are described in the medical and dental literature. A case is reported in which there were posttreatment sequelae from the application of a sillver-nitrate stick (pencil) to an aphthous ulcer on the tongue. Compications subsequent to the use of silver nitrate may contraindicate the use of this agent in its highly concentrated form on the mucous membranes of the mouth.- - - - - - - - - - ranking = 0.0015105321255636keywords = membrane (Clic here for more details about this article) |
9/23. Oral non-dystrophic bullous eruption mainly limited to the gingivae: a mechano bullous response. A variant of cicatricial mucous membrane pemphigoid?Fourteen patients with recurrent blistering entirely restricted to the mouth have been observed for up to 7 years. Their average age was 52 years, and there was a predilection for females (ratio 2-5:1). patients presented with thick-roofed blisters and denuded, red, boggy areas of mucosa. The area of maximal involvement with the labial gingiva, and whilst the blisters would arise spontaneously, mechanical trauma was the obvious provocative factor in all patients. Gentle friction on normal looking mucosa would produce a bulla which became blood filled. re-epithelialization usually occurred within 1-3 weeks, with no scarring. Biopsies showed subepithelial bullae, and direct immunofluorescence was positive in the basement membrane zone of 2 of the 5 cases examined. The most striking feature was the extreme fragility of the epithelial attachment to the underlying corium, as shown by a useful clinical test with a probe. In 10 patients, the condition gradually remitted and the probe test became difficult to perform. The term acquired oral non-dystrophic epidermolysis bullosa was considered for the diagnosis, although a forme fruste of cicatricial mucous membrane pemphigoid remained an alternative.- - - - - - - - - - ranking = 0.29477747846767keywords = mucosa, membrane (Clic here for more details about this article) |
10/23. Treatment of severe recurrent aphthous stomatitis with colchicine.Recurrent aphthous stomatitis (RAS) is characterized by necrotizing ulcers of the oral mucosa that persist, remit, and recur for variable periods of time. Despite the benign nature of the disease, persistent pain and ulceration may disable patients from performing their daily activities. We describe three patients with long-standing active RAS treated with oral colchicine. All patients experienced a marked decrease in symptoms and a remission of the disease. Recurrences, however, occurred within three days of discontinuation of the therapy. In one patient, colchicine therapy was discontinued because of persistent diarrhea. In another, a second remission was more difficult to achieve on the same regimen. The literature on the subject is reviewed, and the beneficial effects of colchicine therapy are discussed in relation to the immunopathogenesis of this disease. We conclude that colchicine therapy should be considered as an alternative in the treatment of the major or persistent form of RAS.- - - - - - - - - - ranking = 0.14285714285714keywords = mucosa (Clic here for more details about this article) |
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