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1/3. Unintentional rapid opioid detoxification.

    naltrexone is a long acting opioid antagonist that is used in rehabilitation programmes to maintain heroin abstinence. It is a relatively new drug prescribed by specialists in substance misuse. Its actions and effects may not be familiar to many accident and emergency doctors or even to the people who take it. A case report is described where accidental ingestion of naltrexone results in a medical emergency by precipitating acute withdrawal in a heroin addict.
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2/3. Withdrawal symptoms in a patient receiving intrathecal morphine via an infusion pump.

    We describe a case of a failed implanted, programmable, intrathecal infusion pump-and its external programmer-leading to morphine withdrawal symptoms, in a patient with failed back syndrome.
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3/3. Effect of innappropriate naltrexone use in a heroin misuser.

    naltrexone is a long acting opioid receptor antagonist used in controlled opioid withdrawal drug programmes. When taken by an opioid dependent patient an acute withdrawal reaction will be precipitated. The case is presented where a known opioid drug misuser inadvertently ingested naltrexone in conjunction with heroin resulting in severe agitation, requiring heavy sedation followed by general anaesthesia to enable investigation and management of his clinical condition.
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keywords = programme
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