1/6. Delayed sulfhemoglobinemia after acute dapsone intoxication.A case of acute dapsone intoxication due to voluntary ingestion of 3 g of this drug as a suicide attempt is described. A severe methemoglobinemia developed, accompanied by intense cyanosis, dyspnea, headache, and nausea. Subsequently, significant sulfhemoglobinemia responsible for prolonged cyanosis was observed, as well as mild hemolytic anemia. Relapses of methemoglobinemia after methylene blue treatment required repeated administration of the reducing agent. The need of a careful follow-up for several days in this type of intoxication is emphasized.- - - - - - - - - - ranking = 1keywords = methemoglobinemia (Clic here for more details about this article) |
2/6. metoclopramide-induced sulfhemoglobinemia.metoclopramide, a drug with oxidant activity, has infrequently been reported to cause methemoglobinemia in infants. We present a unique case in which a patient on chronic metoclopramide therapy developed sulfhemoglobinemia that resolved with subsequent discontinuation of the drug. Mechanisms that may be important in the formation of sulfhemoglobin also are discussed.- - - - - - - - - - ranking = 0.5keywords = methemoglobinemia (Clic here for more details about this article) |
3/6. Congenital sulfhemoglobin and transient methemoglobinemia secondary to diarrhoea.sulfhemoglobinemia and methemoglobinemia are common causes of cyanosis arising due to accumulation of abnormal heme pigment. We present an unusual case of congenital sulfhemoglobinemia along with diarrhoea induced methemo-globinemia in a neonate. A high index of suspicion and a proper diagnostic approach is needed to determine the true frequency of their occurrence together.- - - - - - - - - - ranking = 2keywords = methemoglobinemia (Clic here for more details about this article) |
4/6. sulfhemoglobinemia after dermal application of DMSO.A 43-y-old Caucasian female applied 4 ounces of dimethyl sulfoxide (DMSO) to her lower abdomen for treatment of interstitial cystitis. Within 24 h she developed fatigue, cyanosis and dyspnea with mild exertion. She sought medical attention 10 d later, at which time initial laboratory tests revealed a methemoglobin level of 47%. Two doses of 1 mg methylene blue/kg i.v. were given without significant improvement in either her cyanosis or methemoglobin level. Repeat analysis the day following admission using an outside lab demonstrated a sulfhemoglobin level of 6.2% and a methemoglobin level of < 0.1%. No prior reports have associated sulfhemoglobin formation with DMSO application. carbon monoxide-oximetry may falsely identify sulfhemoglobin as methemoglobin; sulfhemoglobinemia should be considered in cases of methemoglobinemia refractory to methylene blue therapy.- - - - - - - - - - ranking = 0.5keywords = methemoglobinemia (Clic here for more details about this article) |
5/6. Pseudomethemoglobinemia: a case report and review of sulfhemoglobinemia.OBJECTIVES: To see if methemoglobin could potentially be misdiagnosed and the limitation of present cooximeters. PATIENT: A 17-year-old girl who overingested a combination of cimetidine, acetaminophen, ibuprofen, and naproxen in a suicide attempt. METHOD: Use of pulse co-oximeters to aid in the diagnosis of suspected sulfhemoglobinemia. RESULTS: diagnosis of sulfhemoglobinemia achieved with final confirmation made with gas chromatography. Patient steadily improved with supportive care. CONCLUSIONS: There is a potential for the diagnosis of methemoglobin with some of the limitations of present co-oximeters. The laboratory diagnosis of sulfhemoglobinemia can be difficult to make.- - - - - - - - - - ranking = 2keywords = methemoglobinemia (Clic here for more details about this article) |
6/6. phenacetin-induced sulfhemoglobinemia: report of a case and review of the literature.phenacetin-induced sulfhemoglobinemia was diagnosed in a middle-aged woman with a 6-month history of cyanosis and a 10-year history of ingestion of analgesics. The laboratory and clincial diagnosis of sulfhemoglobinemia and methemoglobinemia are discussed. The reviewed medical literature suggests that the cyanosis of chronic phenacetin or acetanilid use is generally due to sulfhemoglobinemia rather than methemoglobinemia.- - - - - - - - - - ranking = 1keywords = methemoglobinemia (Clic here for more details about this article) |