1/7. tissue expansion in a patient with extensive nevus comedonicus.nevus comedonicus is a rare developmental abnormality of the pilosebaceous apparatus that presents as an aggregation of dilated follicular orifices filled with pigmented keratinous material. Occurrence of extensive or giant lesions is even more rare. Indications for treatment include recurrent infections and cosmetic reasons. Therapeutic approaches include topical keratolytic agents, manual extraction of comedones, dermabrasion, and excision of smaller lesions. Increasing clinical experience with tissue expansion has suggested that it might be used effectively in the definitive treatment of an extensive nevus comedonicus previously considered too large to excise without the use of a skin graft, despite the potential risk of infection within the lesion during the course of expansion. We report the first patient with giant nevus comedonicus to be treated using tissue expansion. This patient demonstrates that prompt treatment of cellulitis and abscesses within the lesion will keep this process isolated from the adjacent expanders and will not compromise a planned excision and reconstruction.- - - - - - - - - - ranking = 1keywords = giant (Clic here for more details about this article) |
2/7. Giant vascular eccrine spiradenoma: report of a case with immunohistochemical study.We report a rare case of giant vascular eccrine spiradenoma (GVES) which developed in 56-yr-old Korean woman. It is a rare variant of eccrine spiradenoma (ES), which might be mistaken for angiomatous lesions in view of its florid vascularity and hemorrhagic features. Histogenesis of GVES is not clearly elucidated although it is known that ES presumably originates in the eccrine glands. To clarify the histogenesis of GVES, immunohistochemical stainings using various monoclonal antibodies were also performed. The tumor was composed of three types of cells, namely pale epithelial cells, small basal cells, and myoepithelial cells. Therefore, we conclude that GVES originated from eccrine gland and mainly differentiates toward secretory portion of secretory coil.- - - - - - - - - - ranking = 0.5keywords = giant (Clic here for more details about this article) |
3/7. Syringadenocarcinoma papilliferum.A giant tumor developed on the right chest wall of a 52-year-old housewife over a 20-year period. It was accompanied by a spider-like invasion of skin, and a lymph node was palpated in the right axilla. Wide excision of the lesion was carried out. The cross-section of the tumor showed two different appearances. The tumor was histologically diagnosed as a syringadenocarcinoma papilliferum. The post-operative course was uncomplicated and without evidence of recurrence.- - - - - - - - - - ranking = 0.5keywords = giant (Clic here for more details about this article) |
4/7. Fine-needle aspiration of an apocrine breast carcinoma with multivacuolated, lipid-rich, giant cells.The frequency of mammary apocrine carcinoma varies considerably and reflects the definitional differences of various researchers. Lipid synthesis by malignant mammary cells is not uncommon, and occasionally it is so extensive that the designation lipid-rich carcinoma is warranted. Many subtypes of lipid-rich carcinoma are described. Although focal apocrine change is observed in one type, a tumor composed predominantly of an apocrine carcinoma with an intimate admixture of lipid-rich malignant cells is previously undescribed. The fine-needle aspiration, histologic, and ultrastructural features of such a tumor is delineated for which the descriptive title lipid-rich apocrine carcinoma is coined.- - - - - - - - - - ranking = 2keywords = giant (Clic here for more details about this article) |
5/7. The giant apocrine hidrocystoma.We report a patient with a large apocrine hidrocystoma. These tumors are almost always under 10 mm in diameter. In this 40-year-old man the tumor measured 20 mm. Apocrine hidrocystoma must be considered when evaluating a patient with a large cystic lesion of the face. Surgical management is similar to that of other benign cystic lesions of this region.- - - - - - - - - - ranking = 2keywords = giant (Clic here for more details about this article) |
6/7. Porocarcinoma of the heel. A case report with unusual histologic features.BACKGROUND. eccrine porocarcinoma is an uncommon neoplasm of the intraepidermal sweat gland duct. methods. A case of porocarcinoma of the right heel in a male age 51 years is described with a review of pertinent literature. The surgically excised neoplasm was evaluated by routine histology and transmission electron microscopy. RESULTS. The porocarcinoma showed extensive nuclear pleomorphisms with frequent, multinucleated tumor giant cells, focal epidermotrophic spread within the epidermis, a peripheral, eccrine syringofibroadenoma-like growth pattern, and an origin in a contiguous eccrine poroma. Ultrastructurally, the squamous tumor cells contained rare intracytoplasmic lumens. CONCLUSIONS. The extensive nuclear pleomorphism with frequent tumor giant cells was an unusual feature of the porocarcinoma. Its epidermotrophic spread within the epidermis and its origin in a contiguous eccrine poroma supported the diagnosis of porocarcinoma. The eccrine syringofibroadenoma-like growth pattern in the periphery of the tumor was a unique and previously undescribed feature of the porocarcinoma. The presence of intracytoplasmic lumens in squamous tumor cells mimicked embryonic development of the intraepidermal sweat gland duct.- - - - - - - - - - ranking = 1keywords = giant (Clic here for more details about this article) |
7/7. Giant hidradenocarcinoma: a report of malignant transformation from nodular hidradenoma.A giant hidradenocarcinoma presented by a 75-year-old female is reported. The patient had a malignant transformation within a nodular hidradenoma involving the right postauricular area, which was treated by mass removal and a right radical neck dissection with a free-flap covering. Malignant hidradenocarcinoma is the least common adnexal tumor of uncertain origin. They are usually malignant from their inception, but some develop from a benign counterpart. To the authors' knowledge, only three cases have been reported previously. Two histologically distinct components were seen in this tumor: (i) typical nodular hidradenoma, which constituted a small part of the tumor; and (ii) carcinoma with areas of transition. The secretory cells of hidradenocarcinoma showed decapitation secretion on light and electron microscopic observations, which is evidence of apocrine differentiation. Histologically, this case was concluded as a hidradenocarcinoma arising from a long-standing nodular hidradenoma. A literature review is presented and the histological, immunohistochemical and ultrastructural features are described.- - - - - - - - - - ranking = 0.5keywords = giant (Clic here for more details about this article) |