1/41. Pedal giant cell tumor of tendon sheath.The authors present a brief review of giant cell tumor of tendon sheath and three case reports. A discussion emphasizing the histologic characteristics of this lesion demonstrates the benign-to-malignant variability of these neoplastic growths. Special attention is directed to a case with aggressive histologic characteristics. Reexcision after surgery should be considered in cases where microscopic examination reveals a lesion with characteristics suggestive of potentially aggressive behavior.- - - - - - - - - - ranking = 1keywords = giant (Clic here for more details about this article) |
2/41. Laterosubungual giant cell tumor of the tendon sheath: an unusual location.Giant cell tumor of the tendon sheath is the second most frequent nonepithelial benign tumor of the hand after ganglion cyst. Although it is recognized as a condition that may involve the distal digit, there has been only 1 report of periungual involvement. We describe a second case at that site in this article.- - - - - - - - - - ranking = 0.8keywords = giant (Clic here for more details about this article) |
3/41. Pigmented villonodular synovitis secondary to laceration of the perforating branch of the peroneal artery.A case of peroneal artery injury subsequently developed into a lesion resembling an extra-articular tenosynovial giant cell tumor, which is a type of pigmented villonodular synovitis (PVNS). This case supports the hypothesis that accident trauma, such as a vascular injury, can be the etiology of PVNS.- - - - - - - - - - ranking = 0.2keywords = giant (Clic here for more details about this article) |
4/41. Giant-cell tumor of the synovial membrane: localized nodular synovitis in the knee joint.Giant-cell tumor of the synovia is a benign neoplasm characterized histologically by proliferating histiocytes bearing lipids and hemosiderin intermingled with a variable number of multinuclear giant cells. Areas of predilection are the hand, and in the case of synovial joints, the knee joint is particularly affected. Clinically, patients have signs of mechanical derangement and, with the knee joint, meniscal symptoms and locking are often present. Joint effusion without previous trauma is another typical finding. diagnosis is carried out by radiographic tools and has to be confirmed histologically. Giant-cell tumor of the synovia is treated by local excision either by arthroscopy or by arthrotomy. To our knowledge, the case we present is the largest giant-cell tumor of the synovia in the knee joint ever described in literature.- - - - - - - - - - ranking = 0.4keywords = giant (Clic here for more details about this article) |
5/41. Malignant giant cell tumor of synovium (malignant pigmented villonodular synovitis).CONTEXT: Pigmented villonodular synovitis (PVNS) is a well-recognized entity that has the potential for extensive local destruction, even though it rarely metastasizes. Rare reports of malignant forms are recorded in the literature. We observed 2 patients in whom examples of PVNS followed an aggressive course with multiple recurrences, metastasis, or degeneration to an appearance resembling malignant fibrous histiocytoma. OBJECTIVE: We studied the occurrence and persistence of aneuploidy for chromosomes 5 and 7 in 2 patients with clinically aggressive PVNS. DESIGN: fluorescence in situ hybridization was performed for the detection of chromosomes 5 and 7 in the primary lesions, recurrences, and metastases in 2 examples of PVNS. RESULTS: fluorescence in situ hybridization demonstrated small but significant numbers of cells with trisomies for chromosomes 7 and/or 5 in both the primary and recurrent lesions of both patients. CONCLUSIONS: The presence of consistent chromosomal trisomies (5 and 7) in both patients' examples of PVNS suggests a neoplastic nature for this lesion. The persistence of these trisomies in the primary lesions, recurrences, and metastases supports a molecular link between the primaries, recurrences, and metastases despite changes in morphologic features. The presence of persistent trisomies in the recurrent and metastatic lesions supports the concept of malignant PVNS.- - - - - - - - - - ranking = 0.8keywords = giant (Clic here for more details about this article) |
6/41. Growing wrist mass.A 46 year old man presented with a growing mass over his wrist. Erosions of the triquetrum and hamate were present radiographically. magnetic resonance imaging (MRI) showed a solid mass arising from the extensor carpi ulnaris tendon, which was T(1) hypointense and isointense, T(2) hypointense, and bloomed on gradient echo images. The preoperative diagnosis of giant cell tumour of the tendon sheath was confirmed on histopathological examination of the excised specimen. The clinical, pathological, and imaging features, with emphasis on MRI findings, of this condition are reviewed.- - - - - - - - - - ranking = 0.2keywords = giant (Clic here for more details about this article) |
7/41. Destructive posttraumatic subtalar synovitis.Destructive posttraumatic synovitis is a rare entity usually involving the knee. This case report details the evaluation and treatment of a rapidly progressive and destructive subtalar lesion that occurred in a healthy 27-year-old man after incidental trauma. Initial orthopedic evaluation revealed diffuse ankle tenderness and mild effusion. Radiographic and laboratory studies showed normal findings. Bone scan revealed significantly increased uptake in the talus. Subsequent computed tomography scan and magnetic resonance imaging studies showed a lateral soft-tissue mass invading both the talus and calcaneus with destruction of the subtalar joint. Tissue biopsy samples revealed hypertrophic synovium with villous projections, occasional giant cells, and occasional hemosiderin deposits. The lesion caused rapid and progressive destruction of the subtalar joint despite aggressive conservative measures. Ultimately, the patient underwent a subtalar arthrodesis that led to the resolution of his symptoms and resumption of work and recreational activities. While posttraumatic synovitis is a rarely encountered condition, the orthopedic surgeon must have an index of suspicion, perform a systematic evaluation, and render definitive treatment to ensure a successful outcome.- - - - - - - - - - ranking = 0.2keywords = giant (Clic here for more details about this article) |
8/41. Langerhans cell granulomatosis manifested as pigmented villonodular synovitis.We report an unusual case of Langerhans cell granulomatosis (LCG) manifested as a villous synovial proliferation in a 38-year-old female jogger. One year after the onset of joint symptoms, she had a classical LCG presentation with skin and visceral lymph node involvement. review of the literature revealed only one case of synovial shoulder joint tenosynovitis associated with LCG in a middle-aged woman. Ours is the first reported case presenting clinically in the synovium of the hip joint as pigmented villonodular synovitis. Histiocytic/dendritic proliferations involving the synovial tissues are not uncommon. These lesions as well as the rare multicentric reticulohistiocytosis (MRH), a systemic monocytoid/histiocytic disorder with multinucleated giant cells, polyarthritis, and papulonodular skin lesions, should be considered in the differential diagnosis. Clinical and pathologic features will distinguish LCG from MRH.- - - - - - - - - - ranking = 0.2keywords = giant (Clic here for more details about this article) |
9/41. Cytologic appearance of pigmented villonodular synovitis. A case report.BACKGROUND: Pigmented villonodular synovitis (PVNS) is a benign neoplasm of large joints. It may follow a locally aggressive course. The cytologic features of this neoplasm have not been characterized fully. CASE: A 70-year-old male presented with a lump in the left ankle joint. The histopathologic diagnosis was pigmented villonodular synovitis. review of the cytologic smears revealed clusters of round and ovoid, bland-looking cells along with siderophages and binucleated and multinucleated giant cells. CONCLUSION: When interpreted in the clinical context, fine needle aspiration cytology may render a correct preoperative diagnosis of pigmented villonodular synovitis.- - - - - - - - - - ranking = 0.2keywords = giant (Clic here for more details about this article) |
10/41. Intranuclear inclusions in a case of pigmented villonodular synovitis of the ankle.Pigmented villonodular synovitis (PVNS) is a proliferative disorder of the synovial lining of the joints. Although the cytological findings of this disorder have been described in the literature, there is no mention of intranuclear cytoplasmic inclusions in this entity. A 65-yr-old woman presented with a painful swelling on the ankle. In addition to other characteristic findings of PVNS, we found the presence of intranuclear cytoplasmic inclusions in the fine-needle aspiration (FNA) smears. The characteristic cytological findings of abundant mononuclear cells occurring singly and in papillary clusters, multinucleated giant cells, and hemosiderin deposition should aid in the diagnosis of PVNS and in its differentiation from melanoma and other soft tissue sarcomas, even in the presence of uncommon features such as intranuclear inclusions.- - - - - - - - - - ranking = 0.2keywords = giant (Clic here for more details about this article) |
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