1/19. Pigmented spindle cell carcinoid tumour of the thymus with ectopic adrenocorticotropic hormone secretion: report of a rare variant and differential diagnosis of mediastinal spindle cell neoplasms.AIMS: A variety of histological variants of thymic carcinoid tumour have been described. A rare case of pigmented spindle cell carcinoid tumour of the thymus is documented and compared with the reported cases of thymic pigmented carcinoid tumour in the literature, with a discussion of the differential diagnosis of spindle cell tumours of the mediastinum. methods AND RESULTS: A thymic tumour with ectopic adrenocorticotropic hormone (ACTH) secretion was resected from a 24-year-old man suffering from Cushing's syndrome. Histological, immunohistochemical, and ultrastructural studies revealed an ACTH-producing spindle cell carcinoid tumour harbouring pigmented melanocytes. Among four thymic pigmented carcinoid tumours reported before, only one was similar to the present case by being also an ACTH-secreting pigmented spindle cell thymic carcinoid tumour. The clinicopathological features of this tumour distinguish it from a spindle cell thymoma, spindle cell thymic carcinoma, and other mediastinal spindle cell tumours. CONCLUSIONS: This case illustrates an extremely rare variant of thymic carcinoid tumour exhibiting a spindle cell morphology and harbouring pigmented melanocytes. awareness of this histological variant is important in the differential diagnosis of spindle cell tumours of the mediastinum.- - - - - - - - - - ranking = 1keywords = secretion, hormone (Clic here for more details about this article) |
2/19. syndrome of inappropriate secretion of antidiuretic hormone due to malignant thymoma.The authors present the case of a 51-year-old female with a syndrome of inappropriate secretion of antidiuretic hormone (SIADH) due to a malignant thymoma. Laboratory examinations of the patient showed hyponatremia, plasma hypoosmolarity in the presence of concentrated urine and normal urine excretion of sodium. CT revealed a mass lesion in the mediastinum. A biopsy of the mediastinal mass was performed and the diagnosis of thymoma with SIADH was established. This is a rare description of a malignant thymoma associated with SIADH.- - - - - - - - - - ranking = 154.40978378929keywords = inappropriate secretion, antidiuretic hormone, antidiuretic, secretion, hormone (Clic here for more details about this article) |
3/19. Thyroid and thymic malignancy following childhood irradiation.Synchronous thyroid and thymic malignancy following childhood thymic irradiation has only been reported in two known cases previously, with a third case identified here. A rationale is presented for following these radiated patients as they age with thyroglobulin and thyroid-stimulating hormone (TSH) levels as a measure of risk of the development of nodular thyroid disease and, if such occurs, for an aggressive surgical approach. There exists a growing population at risk attributable to the success of radiation treatment of Hodgkin's and pediatric head and neck tumors. The question is raised regarding the theoretical benefits of thyroid suppressive therapy in this group at risk. With the instructive case presented, radical surgery for either thymic or thyroid carcinoma and careful monitoring for decades-late local recurrences of thymoma are suggested.- - - - - - - - - - ranking = 0.024326507566613keywords = hormone (Clic here for more details about this article) |
4/19. Effect of hypothalamic extract and other factors on release of adrenocorticotropin from and adenosine 3',5'-monophosphate levels in dispersed nonpituitary tumor cells.Tumor tissues obtained from two patients with the ectopic ACTH syndrome caused by medullary carcinoma of the thyroid and malignant epithelial thymoma were dispersed by tryptic digestion and mechanical agitation. Using the isolated cells, the effects of various agents on ACTH secretion and intracellular cAMP concentrations were studied. Addition of rat median eminence extract significantly stimulated ACTH secretion and increased levels of intracellular cAMP in both cell preparations, and a dose-response relationship appeared to exist between the dose of rat median eminence extract added and either ACTH secretion or intracellular cAMP formation in the thymic tumor cells. High concentrations of calcium also produced a marked ACTH secretion in both cases. In the thymic tumor cells, norepinephrine, serotonin, and TRH were found to be effective in increasing ACTH secretion and intracellular cAMP levels, whereas biogenic amines, hypothalamic hormones, and gastrointestinal hormones did not affect hormone secretion in the thyroid tumor cells. These results suggest that a corticortropin-releasing factor-like substance(s), as yet unspecified, may play some role in stimulating ectopic ACTH secretion by certain tumors, that both intracellular cAMP and Ca may be involved in ectopic hormone secretion, and that the inappropriate hormonal secretory responses of some tumors to a variety of stimuli might be mediated by altered membrane receptors of the neoplastic cells.- - - - - - - - - - ranking = 1.5026939697335keywords = secretion, hormone (Clic here for more details about this article) |
5/19. "Disappearing" spinal cord compression: oncolytic effect of glucocorticoids (and other chemotherapeutic agents) on epidural metastases.Four patients suffering spinal cord compression resulting from epidural metastases were treated with adrenocorticosteroid hormones. For 2 patients, prompt relief of symptoms followed glucocorticoid therapy alone and was associated with marked shrinkage or disappearance of the metastasis, a direct oncolytic effect of the steroids. For the other 2 patients, glucocorticoids combined with other chemotherapeutic agents caused disappearance of the extradural tumor. For 1 patient, failure to recognize the oncolytic effects of the chemotherapy led to an unnecessary surgical procedure, and for a second patient an unnecessary operation was narrowly averted. Thus, for certain patients, glucocorticoids may occasionally have a marked oncolytic effect on epidural metastatic tumors.- - - - - - - - - - ranking = 0.024326507566613keywords = hormone (Clic here for more details about this article) |
6/19. Bronchogenic carcinoma producing ectopic steroid hormones.A patient with steroid hormones or androgen producing bronchogenic adenocarcinoma was presented. Clinically he had a mediastinal mass and bilateral multiple pulmonary nodules which showed a rapid growth despite cancer chemotherapy. At postmortem examination, radioimmunoassay of the tumor tissue revealed androgen and their precursors. The mitochondria of the tumor cells resembled those of cells in the zona reticularis of the adrenal cortex.- - - - - - - - - - ranking = 0.12163253783306keywords = hormone (Clic here for more details about this article) |
7/19. Steroid therapy in inappropriate secretion of antidiuretic hormone due to malignant thymoma.The authors present the case of a 48-year-old female known to have malignant thymoma with metastases for 6 years and treated continuously for 4 years by corticosteroids with marked regression of tumor. The patient ceased medication on her own accord, and was admitted with extensively enlarged tumor and metastases in association with the syndrome of inappropriate secretion of antidiuretic hormone (SIADH). In view of the previous excellent response of the thymoma to corticosteroids, the same treatment was given again with disappearance of the tumor and the features of SIADH. The authors are unaware of previous use of corticosteroids in SIADH as a consequence of their effect on tumor regressions.- - - - - - - - - - ranking = 154.40978378929keywords = inappropriate secretion, antidiuretic hormone, antidiuretic, secretion, hormone (Clic here for more details about this article) |
8/19. syndrome of inappropriate antidiuretic hormone secretion following dis-dichlorodiammineplatinum II in a patient with malignant thymoma.A patient with malignant thymoma is reported, in whom the syndrome of inappropriate antidiuretic hormone secretion (SIADH) occurred 36-48 hours after being given cis-Dichlorodiammineplatinum II (CPPD) with a mannitol diuresis. The SIADH was treated by fluid restriction and demeclocycline and subsided after approximately 72 hours. Subsequent courses of CPPD with mannitol diuresis were given with demeclocycline prophylactically and no untoward effects noted. The precise mechanism for the SIADH following the use of CPPD is unknown, but may be life-threatening, especially since preloading with fluid followed by forced diuresis is used when CPPD is given to avoid nephrotoxicity. The patient has survived 37 months, with 24 months of relapse-free survival following treatment with CPPD, irradiation and surgery.- - - - - - - - - - ranking = 25.720935895059keywords = antidiuretic hormone, antidiuretic, secretion, hormone (Clic here for more details about this article) |
9/19. thymoma with hypersecretion of thymic hormone.A 78-yr-old patient presented with a malignant thymoma with a predominance of epithelial cells. Lymphocyte markers (E rosettes, T-cell-specific xenoantigen and surface Ig) and electrophoretic studies showed that more than 95% of the peripheral blood lymphocytes were T cells. High levels of circulating thymic factor were repeatedly found before treatment (irradiation and chemotherapy). It is suggested that inappropriate hypersecretion of thymic hormone is responsible or can contribute to the immunological abnormalities found in this patient.- - - - - - - - - - ranking = 1keywords = secretion, hormone (Clic here for more details about this article) |
10/19. Pure red cell aplasia following irradiation of an asymptomatic thymoma.An unusual case of pure red-cell aplasia (PRCA) developed sixteen days after irradiation of an asymptomatic thymoma. After removal of the encapsulated thymoma there was no improvement in the anemia, and no response to adrenocortical and anabolic steroid hormones or immunosuppressive agents.- - - - - - - - - - ranking = 0.024326507566613keywords = hormone (Clic here for more details about this article) |
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