1/5. Isolated central diabetes insipidus in a newborn with congenital toxoplasmosis.We present a 5 day-old male newborn with isolated central diabetes insipidus due to congenital toxoplasmosis. This patient was referred to us for hydrocephalus. As we investigated the aetiology of the hydrocephalus, the patient's serum and cerebrospinal fluid tested positive for toxoplasmosis via ELISA and polymerase chain reaction. Computed tomography showed obstructive hydrocephalus and disseminated cranial calcifications. Central diabetes insipidus developed on the 10th day, apparently as a result of the toxoplasmosis infection, and was treated successfully with oral desmopressin.- - - - - - - - - - ranking = 1keywords = diabetes insipidus, insipidus, diabetes (Clic here for more details about this article) |
2/5. Neuroendocrine abnormalities in a neonate with congenital toxoplasmosis.The central nervous system is often affected in patients with congenital toxoplasmosis. However, hypothalamo-pituitary dysfunction has rarely been reported in children with congenital toxoplasmosis, and no case with prolonged fever of central origin has been documented so far. We describe a newborn with congenital toxoplasmosis who presented with fever due to hypothalamo-pituitary dysregulation and combined hypothalamo-pituitary deficiencies consisting of central diabetes insipidus, hypothyroidism and ACTH deficiency.- - - - - - - - - - ranking = 0.16666666666667keywords = diabetes insipidus, insipidus, diabetes (Clic here for more details about this article) |
3/5. Hypothalamo-pituitary dysfunction in congenital toxoplasmosis.Three patients with congenital toxoplasmosis and hypothalamo-pituitary dysfunction are reported. All three children were growth hormone (GH) deficient, two were gonadotropin deficient and one had precocious puberty in addition to central diabetes insipidus (DI). It is suggested that congenital toxoplasmosis might result in a neuro-endocrine disturbance and thus be an organic cause of hypopituitarism. Pituitary function and growth should be monitored in children with congenital toxoplasmosis.- - - - - - - - - - ranking = 0.16666666666667keywords = diabetes insipidus, insipidus, diabetes (Clic here for more details about this article) |
4/5. Congenital toxoplasmosis complicated by central diabetes insipidus in an infant with down syndrome.We describe an infant with the unusual combination of down syndrome, congenital toxoplasmosis, and central diabetes insipidus. hydrocephalus was documented by fetal ultrasonography at 36 weeks' gestation. He developed central diabetes insipidus as a neonate, followed by interstitial pneumonia, anemia, and hepatosplenomegaly. The patient's serum titer for toxoplasma-specific IgM (ELISA) at 37 days after delivery was negative, but the toxoplasma SAG1 gene was detected from the cells of the cerebrospinal fluid on the same day using the polymerase chain reaction (PCR) method. Congenital toxoplasmosis can contribute to the development of central diabetes insipidus in infants. PCR was useful in diagnosing congenital toxoplasmosis rapidly and accurately.- - - - - - - - - - ranking = 1.1666666666667keywords = diabetes insipidus, insipidus, diabetes (Clic here for more details about this article) |
5/5. Central diabetes insipitus in a patient with congenital toxoplasmosis.A 33-day-old male infant who developed central diabetes insipitus as a complication of congenital toxoplasmosis is presented. He had polyuria and hypernatremia on admission and responded to Intranasal desmopressin acetate with the normalization of above mentioned findings. Computed tomographic (CT) scan of the brain showed obstructive hydrocephaly with periventricular and right basal ganglion calcification. CT scan of the pituitary gland, thyroid function tests, and serum cortisol levels were all normal. This is the first report of isolated diabetes insipitus with congenital toxoplasmosis in literature and central diabetes insipitus should be remembered if polyuria and hypernatremia develops in a patient with congenital toxoplasmosis.- - - - - - - - - - ranking = 0.011606872672215keywords = diabetes (Clic here for more details about this article) |