1/52. Necrotizing conjunctival ulceration following subconjunctival depot methylprednisolone injection.To report the occurrence of a necrotizing conjunctival ulcer at the site of methylprednisolone injection. A 35-year-old woman underwent a routine extracapsular cataract extraction. Subconjunctival methylprednisolone acetate (Depo-Medrol, Pharmacia & Upjohn, Kalamazoo, MI) was injected at the end of the operation. A necrotizing conjunctival ulcer developed at the site of injection. Necrotic tissue and remnants of the drug were excised, and the conjunctiva healed within 10 days. Postoperative subconjunctival injection of methylprednisolone may cause necrosis and ulceration of the overlying conjunctiva. Subconjunctival and subtendon corticosteroid injections are commonly used in various inflammatory ocular conditions and prophylactically after intraocular operations. We describe a case of conjunctival necrosis at the site of injection, an adverse effect that has been previously reported in only 1 case in the ophthalmological literature.- - - - - - - - - - ranking = 1keywords = ocular (Clic here for more details about this article) |
2/52. Intestinal Behcet's disease associated with myelodysplastic syndrome with chromosomal trisomy 8--a report of two cases and a review of the literature.Two cases of intestinal Behcet's disease, which developed in the state of myelodysplastic syndrome with trisomy 8, are presented. Both cases are included in the incomplete type of Behcet's disease, with recurrent aphthous stomatitis, skin lesions, genital ulcers or vascular involvement and punched-out ulcers in the cecum, without ocular involvement. The chromosomal analyses revealed chromosomal abnormalities, including trisomy 8, in both cases. Chromosomal trisomy 8 was shown in all 6 cases with the intestinal Behcet's disease associated with myelodysplastic syndrome reported previously, including our patients. Their histories indicated that myelodysplastic syndrome might have started before the development of intestinal Becet's disease. Theses findings suggested that chromosomal trisomy 8 might play an important role in the pathogenesis, at least in some groups, of intestinal Behcet's disease.- - - - - - - - - - ranking = 0.5keywords = ocular (Clic here for more details about this article) |
3/52. Conjunctival ulceration in recurrent wegener granulomatosis.PURPOSE: To describe a patient with wegener granulomatosis (WG) previously in remission who developed conjunctival ulceration as the first sign of disease recurrence. methods: Case report and review of the literature. RESULTS: Twenty-one years after WG was originally diagnosed and with the disease thought to be in remission, a 52-year-old man with complaints of ocular irritation for the previous year was found to have multiple palpebral conjunctival ulcerations of the left eye. Incisional biopsy revealed mixed inflammation consistent with WG. Within 3 months of recognition of his conjunctival ulcers, newly recurrent pulmonary inflammation developed and serologies for cytoplasmic-pattern antineutrophil cytoplasmic antibodies (C-ANCA) became positive. CONCLUSION: Conjunctival ulceration is a rare manifestation of WG but may presage more widespread disease. Mucosal ulceration in a patient with a previous diagnosis of WG should stimulate an aggressive search for renewed systemic disease activity.- - - - - - - - - - ranking = 0.5keywords = ocular (Clic here for more details about this article) |
4/52. Conjunctival ulcer--mucocutaneous or ocular manifestation of Behcet's disease? A case report.PURPOSE: To report the rare occurrence of conjunctival ulceration in a patient with Behcet's disease. methods: Case report. A 35 year old "Behcet's suspect" on azathioprine presented to the ophthalmic emergency room with a painful ulceration involving the inferior palpebral conjunctiva of her left eye. RESULTS: The ulcer responded to treatment with topical steroids and healed without scarring. CONCLUSIONS: Conjunctival ulceration is not a common manifestation of Behcet's disease. Its occurrence during maintenance therapy with azathioprine in a patient with Behcets could be either incidental or indicate inadequate immunosuppression.- - - - - - - - - - ranking = 2keywords = ocular (Clic here for more details about this article) |
5/52. Development of large genital ulcer due to hydroxyurea treatment in a patient with chronic myeloid leukemia and Behcet's disease.Chronic myeloid leukemia (CML) is a myeloproliferative disease arising from abnormal stem cells and associated with splenomegaly and leukocytosis. hydroxyurea and interferon alpha are used in treatment very frequently. Behcet's disease (BD) is a chronic, repetitive disease of unknown etiology and associated with mucocutaneous, ocular, vascular and central nervous system involvement. Cases with symptoms of BD have been reported during interferon alpha treatment of CML. However, similar symptoms due to hydroxyurea treatment have been reported in only one case until now. A 32-year-old female patient under follow up because of CML and BD, developed a large genital ulcer during hydroxyurea treatment. Ulcers due to hydroxyurea treatment and the co-existence of these two diseases has been reported in only one case in the literature while large genital ulcers have not been reported previously.- - - - - - - - - - ranking = 0.5keywords = ocular (Clic here for more details about this article) |
6/52. Conjunctival ulceration following triamcinolone injection.PURPOSE: To report conjunctival ulceration as a complication of periocular triamcinolone acetonide injection.Interventional case series. methods: Conjunctival ulceration was found in three patients who had anterior subtenon's or subconjunctival deposition of triamcinolone. Cultures from the ulcer edges were negative. RESULTS: Most of the triamcinolone extruded, and the conjunctival ulcers healed with minimal scarring. CONCLUSIONS: Conjunctival ulceration was a potential complication of periocular triamcinolone injection in three patients who had anterior subtenon's or subconjunctival deposition of the corticosteroid.- - - - - - - - - - ranking = 1keywords = ocular (Clic here for more details about this article) |
7/52. Multisystem disorder of Punjabi children exhibiting spontaneous dermal and submucosal granulation tissue formation: logic syndrome.We describe a multisystem disease that affects children of Muslim families originating in the Punjab region of pakistan and india. An altered cry due to vocal cord thickening, skin ulceration, nail abnormalities, and conjunctival scarring appear in the first few months of life. Progression and spread of the disease in these sites may be accompanied by involvement of other epithelial surfaces. The teeth may exhibit defective enamel formation. histology reveals the formation of simple granulation tissue arising in the dermis and submucosa which become massively thickened and ulcerated. There is good evidence for an autosomal recessive gene defect, but the actual mechanism of the disease is not known. Medical and surgical therapy have been ineffective in altering the course of this devastating and usually fatal condition. We suggest the term logic (laryngeal and ocular granulation tissue in children from the Indian subcontinent) for this newly established disease.- - - - - - - - - - ranking = 0.5keywords = ocular (Clic here for more details about this article) |
8/52. Unusual presentation of early lymphogranuloma venereum in an hiv-1 infected patient: effective treatment with 1 g azithromycin.The incidence of lymphogranuloma venereum (LGV) is low in the western world. Early LGV is characterised by bubonic disease following a painless papule or small ulcer. We report a white bisexual male who presented with a painful perianal ulcer, inguinal lymphadenitis, and concomitant infection with human immunodeficiency virus 1 (hiv-1). chlamydia trachomatis serovar L2 was identified as the cause after polymerase chain reaction and genotyping the major outer membrane protein by restricted fragment length polymorphism. Treatment with a single dose of 1 g azithromycin was effective. This case illustrates that early LGV may mimic other genital ulcer diseases, such as genital herpes or chancroid, especially in HIV infected patients. In the western world, LGV must still be included in the differential diagnosis of bubonic disease with or without sexually acquired ulcers.- - - - - - - - - - ranking = 34.529510293331keywords = herpes (Clic here for more details about this article) |
9/52. Successful management of vulvar adhesions with potent topical corticosteroids: a case report.BACKGROUND: Vulvar adhesions are a rarely reported but clinically recognized complication of severe ulcerations following herpes genitalis. The condition is avoidable with adequate pharmacologic treatment, hygiene, separation of the labia and topical application of skin emollients. CASE: Vulvar agglutination was diagnosed in a 23-year-old woman following hospitalization for severe herpetic vulvar ulcerations. Manual attempts to separate the labia under local anesthesia were unsuccessful. Topical application of a potent cortico- steroid led to separation with no residual effects. CONCLUSION: Preventive and proactive management of extensive herpetic vulvar ulcerations should be the first line of care. There will always be patients who will present at a later stage of the disease, with established vulvar agglutination; there potent topical corticosteriods could prove valuable. There is no literature on the use of topical corticosteroids as the primary treatment for vulvar adhesions, and further studies are essential.- - - - - - - - - - ranking = 34.529510293331keywords = herpes (Clic here for more details about this article) |
10/52. Ulcus vulvae acutum, a rare diagnosis to keep in mind.Genital ulceration is today often thought to be caused by herpes simplex. In this case report, a rare differential diagnosis, ulcus vulvae acutum is described, probably caused by Epstein-Barr virus (EB-virus).- - - - - - - - - - ranking = 389.28912478671keywords = herpes simplex, simplex, herpes (Clic here for more details about this article) |
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