1/86. Periurethral vaginal adenocarcinoma of the intestinal type: report of two cases and review of the literature.INTRODUCTION: Vaginal adenocarcinomas in the absence of diethylstilbestrol (DES) exposure are rare neoplasms. Only a few cases with enteric type histology have been reported. Also rare are urethral adenocarcinomas in women. case reports: Two cases of vaginal adenocarcinoma of the intestinal type in the absence of DES exposure are presented. Both cases arose in the periurethral area, raising the issue of urethral as well as vaginal origin. DISCUSSION: The possible histogenesis of these neoplasms is considered.- - - - - - - - - - ranking = 1keywords = adenocarcinoma (Clic here for more details about this article) |
2/86. Urinary cytologic findings in patients with benign and malignant adenomatous polyps of the prostatic urethra.CONTEXT: Urethral adenomatous polyps with prostatic epithelium (also known as benign prostatic epithelial polyps [BPEPs]) are a documented cause of hematuria, dysuria, and hematospermia, conditions that may prompt cytologic evaluation of urine. DESIGN: The urine cytologic test findings in 5 cases of biopsy-proven BPEPs and in 1 case of prostatic ductal adenocarcinoma (PDA) that presented as a urethral polyp were retrospectively evaluated. Immunocytochemical stain for prostate-specific antigen (PSA), prostatic acid phosphatase (PAP), and high-molecular-weight cytokeratin (34betaE12) were used in evaluation of the lesions. RESULTS: In 4 of 5 cases of BPEPs, clusters of bland columnar cells with uniform, oval nuclei were seen. Positive immunostaining for PSA and PAP confirmed the prostatic origin of the clusters in 2 cases. One urine sample contained abundant goblet cells and extracellular mucin, consistent with intestinal metaplasia coexisting in the bladder biopsy specimen. The urine sample in the fifth case of BPEPs contained no columnar cells. The last case had multiple urine cytologic evaluations that demonstrated PSA-positive, malignant-appearing clusters of columnar cells. A biopsy specimen of the polyps was described as a high-grade prostatic intraepithelial neoplasm in adenomatous polyp. However, in this patient, PDA was diagnosed on transurethral resection of the prostate specimen 4 years after the initial urine cytologic test. CONCLUSION: Benign prostatic epithelial polyps should be considered in the differential diagnosis of clusters of columnar cells in urine cytologic testing. Cells with malignant nuclear features should instigate a careful search for a (prostatic) neoplasm, which may present as urethral polyps (e.g., PDA). Stains for PSA or PAP are useful adjuncts in differential diagnosis of this condition.- - - - - - - - - - ranking = 0.14285714285714keywords = adenocarcinoma (Clic here for more details about this article) |
3/86. Clear cell adenocarcinoma in a female urethral diverticulum.The incidence of a neoplasm within the female urethral diverticulum is rare. Clear cell adenocarcinoma, which is the most common neoplasm, arises from the metaplasia of surface transitional epithelium and the paraurethral ducts. These tumors are usually diagnosed at a late stage, which worsens their prognosis. The treatment of choice is surgery.- - - - - - - - - - ranking = 0.71428571428571keywords = adenocarcinoma (Clic here for more details about this article) |
4/86. Colonic type adenocarcinoma of male urethra.A case of rare primary adenocarcinoma of the bulbomembranous portion of the male urethra is presented. The histological and immunohistochemical characteristics of this tumor are identical to those of colon adenocarcinomas. The pathogenesis can be explained either by neoplastic degeneration of globet cells found in the urethral epithelium or by malignant degeneration of persistent glandular elements that are embryonal residues. The patient was successfully treated with transurethral prostatectomy and with a high dose of radiation therapy.- - - - - - - - - - ranking = 0.85714285714286keywords = adenocarcinoma (Clic here for more details about this article) |
5/86. female urethral adenocarcinoma arising from urethritis glandularis.INTRODUCTION: female urethral adenocarcinoma is extremely rare and more than one tissue of origin has been suggested other than the Skene's gland. immunohistochemistry with cytokeratins (CK) 7 and 20 is used to define the origin of the tumor. CASE REPORT: A 72-year-old woman presented with a 2-cm polypoid tumor at the external urethral meatus and bleeding. Wide local excision and bilateral inguinal lymphadenectomy were performed. Postoperative convalescence was uneventful. It was a poorly differentiated mucinous adenocarcinoma without direct urothelial involvement. There were focal areas of intestinal metaplasia. The tumor cells were positive for CK 7 and 20 and negative for prostate-specific antigen. DISCUSSION: This case provides supportive evidence that mucinous urethral adenocarcinoma may arise from malignant transformation of urethritis glandularis.- - - - - - - - - - ranking = 1keywords = adenocarcinoma (Clic here for more details about this article) |
6/86. A long-term course of a primary urethral/paraurethral adenocarcinoma.The authors report a rare case of primary urethral/paraurethral adenocarcinoma in a female patient. The tumor was first detected at the external and internal urethral orifices, with later recurrences in the region of the urinary bladder neck. histology did not reveal the exact origin of the malignancy. The patient was treated by transurethral resection, regularly repeated during the 3-6-monthly checks. Five years after diagnosis she remains symptom free and has a high quality of life.- - - - - - - - - - ranking = 0.71428571428571keywords = adenocarcinoma (Clic here for more details about this article) |
7/86. female clear cell adenocarcinoma arising within a urethral diverticulum.Clear cell adenocarcinomas arising from female urethral diverticulae are rare. The optimal management of this clinical entity is uncertain. Two cases managed by a combination of surgery and XRT (radiotherapy) are presented. The common histopathological findings and treatment options are highlighted. Individualized patient management in a multi-disciplinary setting is recommended.- - - - - - - - - - ranking = 0.71428571428571keywords = adenocarcinoma (Clic here for more details about this article) |
8/86. Clear cell adenocarcinoma of the male urethra in association with so-called nephrogenic metaplasia.A clear cell adenocarcinoma of the urethra associated with so-called nephrogenic metaplasia occurring in a 57-year-old male patient is presented. Ten months following total urethrectomy, multiple pulmonary metastases had developed. The patient died 2.5 years after surgery. The possible histogenesis of clear cell adenocarcinoma of the lower urinary tract - reported to develop in the male urethra only in a very few cases - is reviewed briefly. We favor an origin from preexisting nephrogenic metaplasia as one of the possible histogenetic pathways.- - - - - - - - - - ranking = 0.85714285714286keywords = adenocarcinoma (Clic here for more details about this article) |
9/86. Use of a urethral occlusion device for treatment of incontinence in a patient with heterotopic urinary diversion.Incontinence is a frequent complication of continent cutaneous urinary diversion that usually requires surgical intervention for correction. We report a novel nonsurgical therapy for reservoir incontinence in a woman who underwent anterior pelvic exenteration with formation of an indiana pouch urinary diversion for treatment of adenocarcinoma of the urethra. When she subsequently developed urinary incontinence that was only partially responsive to anticholinergic therapy, stomal continence was restored by using a disposable urethral occlusion device.- - - - - - - - - - ranking = 0.14285714285714keywords = adenocarcinoma (Clic here for more details about this article) |
10/86. Primary signet ring cell carcinoma of female urethra.A 69-year-old woman presented with difficulty in urination and bloody fluid discharge from the urethra. Based upon a diagnosis of primary urethral carcinoma, she underwent total cysto-urethrectomy and hysterectomy with pelvic lymph node dissection and urinary diversion of ileal conduit. Microscopically, the tumor was composed of mucinous adenocarcinoma and signet ring cell carcinoma. There was no recurrence 17 months after the surgery.- - - - - - - - - - ranking = 0.14285714285714keywords = adenocarcinoma (Clic here for more details about this article) |
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