1/5. Evaluation of plasmids in tetracycline resistant strains of neisseria gonorrhoeae and ureaplasma urealyticum in a case of severe urethritis.A young man who acquired gonococcal urethritis in the far east was not cured by repeated i.v. treatment with a broad-spectrum penicillin. Cultures of pre- and post-treatment urethral specimens grew tetracycline-resistant penicillinase-producing neisseria gonorrhoeae (PPNG) and tetracycline-resistant ureaplasma urealyticum. The patient was successfully treated with erythromycin, to which both isolates were sensitive. The strain of N. gonorrhoeae carried a novel plasmid of 10.5 Md molecular mass in addition to plasmids previously observed in this organism. The strain of U. urealyticum carried two distinct plasmids, one with mass 4.9 Md and the other one with mass 8.1 Md. This report demonstrates that ureaplasmas can contain plasmids and raises the question if tetracycline resistance is controlled by plasmids or by the chromosome.- - - - - - - - - - ranking = 1keywords = ureaplasma (Clic here for more details about this article) |
2/5. ureaplasma urealyticum causing persistent urethritis in a patient with hypogammaglobulinaemia.ureaplasma urealyticum organisms (ureaplasmas) were isolated in large numbers (up to 10(8) colour changing units (ccu)/ml) over a period of four years from the urethra of a man with hypogammaglobulinaemia and non-gonococcal urethritis. Elimination of mycoplasma hominis by antibiotic treatment early in the course of the urethritis did not diminish the severity of his condition, which indicated that this mycoplasma was not a cause. Courses of treatment with tetracyclines, spectinomycin, erythromycin, rosaramicin, and clindamycin on each occasion reduced the numbers of ureaplasma isolated from the urethra and the severity of disease. The organisms were not eliminated, however, sometimes due to the development of antibiotic resistance, and the urethritis recurred. Though netilmicin was not particularly effective in vitro, it was effective clinically, the disease resolving and the organisms disappearing for five months. recurrence of urethritis, accompanied by epididymitis, was associated this time with the recovery of a different (tetracycline sensitive) ureaplasma strain; the urethritis and epididymitis were treated successfully with a combination of netilmicin and doxycycline. The administration of ureaplasma antiserum did not seem to be instrumental in eradicating the ureaplasmas. The various antibiotics had a greater influence on the mycoplasmas in the urethra than on those in the throat and joints, perhaps because the antibiotics were concentrated in the urogenital tract. The close association between the occurrence of urethritis and the ureaplasmas suggests strongly that they were responsible for it.- - - - - - - - - - ranking = 6keywords = ureaplasma (Clic here for more details about this article) |
3/5. Ureaplasma-infected human sperm in infertile men.The case of an infertile man with oligospermia and symptoms of urethritis-prostatitis, whose spouse had a vaginal discharge, is reported. Microbiological analysis of appropriate specimens revealed a strain of tetracycline-resistant ureaplasma urealyticum in both patients. Using the transmission electron microscope, it was possible to demonstrate spermatozoal heads "infected" with microorganisms strongly resembling ureaplasma urealyticum.- - - - - - - - - - ranking = 2keywords = ureaplasma (Clic here for more details about this article) |
4/5. Persistent nongonococcal urethritis associated with a minocycline-resistant strain of ureaplasma urealyticum: a case report.culture of urethral specimens from a 21-year-old man with nongonococcal urethritis yielded both chlamydia trachomatis and a minocycline-resistant strain of ureaplasma urealyticum. In such situations, the causal agent of the urethritis is frequently considered to be C. trachomatis. However, the etiology of this case was more probably linked to U. urealyticum. This conclusion emerged after observation of the following events: (1) the patient was not cured by a standard course of minocycline, despite the elimination of the chlamydiae; and (2) clinical recovery was achieved by treatment with a different drug (erythromycin), to which the ureaplasmas were susceptible and by which they were eradicated.- - - - - - - - - - ranking = 1keywords = ureaplasma (Clic here for more details about this article) |
5/5. Chronic cystitis and urethritis associated with ureaplasmal and mycoplasmal infection in primary hypogammaglobulinaemia.Six of 58 patients with primary hypogammaglobulinaemia developed chronic urethritis and/or cystitis. We have some evidence that this complication may be caused by infection with strains Rof ureaplasma urealyticum. This is important because ureaplasmas are usually resistant to most antibiotics routinely used to treat lower urinary tract infections. It appears that hypogammaglobulinaemic patients develop less localised and more severe ureaplasmal infections than immunocompetent subjects, which indicates that antibodies are important in controlling the growth of these organisms in the bladder and urethra.- - - - - - - - - - ranking = 6keywords = ureaplasma (Clic here for more details about this article) |